Abstract:Alzheimer's disease (AD), a neurodegenerative disease, has a complex pathological mechanism involving oxidative stress, endoplasmic reticulum (ER) stress and other pathways. Thioredoxin 1 (Trx-1), the major redox regulator, may be an effective treatment strategy for AD. Therefore, the present study explored the role and possible mechanism of Trx-1 in AD. The expression of Trx-1 in the hippocampus of AD was verified by WB and RT-PCR, and the effects of Trx-1 on behavioral function and neuropathological damage o… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.