Thiopurines prevented surgical recurrence in patients with Crohn's disease after intestinal resection: Strategy based on risk stratification

Guo, Jing; Chen, Baili; Chen, Zhihui; Luo, Xia-peng; Qiu, Yun; Zhang, Shenghong; Feng, Rui; He, Yao; Zeng, Zhirong; Song, Xin-Ming; Ben‐Horin, Shomron; Mao, Ren; Chen, Minhu

doi:10.1111/jgh.13922

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…The existing data supported that smoking history 27,28 , penetrating lesions 27,29 , postoperative perianal lesions 28,29 and emergency surgery 28 were risk factors for postoperative recurrence, whereas azathioprine 27 , antitumor necrosis factor 29 and mesenteric resection 30 were protective factors. Due to the long-term use of glucocorticoids, immunosuppressive agents and malnutrition in patients required surgical treatment, one-stage temporary ostomy to improve nutritional status, as well as two-stage ostomy and intestinal anastomosis were common modes of operation under these circumstances.…”

Section: Discussionmentioning

confidence: 78%

No Association between staging operation and the 5-Year Risk of Reoperation in Patients with Crohn’s Disease

Zhou

Gong

et al. 2019

Sci Rep

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The aim of this study was to investigate the impact of staging operation on the risk of reoperation in patients with CD who underwent primary bowel resection. This was a retrospective study of 980 patients with CD who were hospitalized in Jinling Hospital Affiliated to Nanjing Medical University between January 1, 2001, and October 1, 2016. The patients were grouped according to staging operation (n = 64) and one-stage operation (n = 148). Postoperative intestinal function recovery time, postoperative short-term complications, and reoperation rates were compared between the two groups. There was significant difference in disease behavior between the staging operation group and the one-stage operation group. There was no significant difference in postoperative tolerance of enteral nutrition among groups (P > 0.05). Obvious differences were found in the comparison of the first time of exhaustion, defecation after operation, postoperative length of stay and postoperative complications among groups (all P < 0.05). There was no difference in the 5-year cumulative reoperation-free rates between the two groups (P > 0.05). In conclusion, surgical intervention at proper time and appropriate operation during operation are essential for patients with CD. It is believed that staging operation with ostomy followed by intestinal anastomosis is feasible when there are more than two risk factors for postoperative intra-abdominal infectious complications.

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Section: Discussionmentioning

confidence: 78%

No Association between staging operation and the 5-Year Risk of Reoperation in Patients with Crohn’s Disease

Zhou

Gong

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

Thiopurines prevented surgical recurrence in patients with Crohn's disease after intestinal resection: Strategy based on risk stratification

Abstract: Penetrating disease behavior and ileocolonic/isolated (UGID) location were associated with SR in CD patients. TPs use was beneficial in decreasing risk for SR in CD patients at high risk.

Cited by 1 publication

References 27 publications

No Association between staging operation and the 5-Year Risk of Reoperation in Patients with Crohn’s Disease

No Association between staging operation and the 5-Year Risk of Reoperation in Patients with Crohn’s Disease

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