Thiophene Scaffold as Prospective Antimicrobial Agent: A Review

Abstract

Thiophene has emerged as a potent scaffold that has pulled the keen interest of the researchers because of its considerable diversity in biological activities. The versatility of the thiophene nucleus is demonstrated by the successful introduction of its derivatives, which have anti‐inflammatory (Thenaldine), anticancer (Ralitrexed), antioxidant (Erdosteine), and antimicrobial (Cefoxitin and Temocillin) activities. This decent variety in the biological response profile has pulled in the consideration of numerous researchers to research this skeleton to its distinctive potential against several activities. This review is integral to prior reviews and plans to review the work regarding antibacterial and antifungal activities of thiophene, substituted thiophene and thiophene‐like compounds, and also Schiff bases of thiophene and substituted thiophenes from year 1995 to the beginning of 2018.

Synthesis, Characterization, and Biological Evaluation of Novel 7-Oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic Acid Derivatives

“…In a recent study, heterocycle-fused thiazole derivatives have been synthesized and investigated with the aim of finding effective antimicrobial agents [6]. In this respect, many thieno [2,3-d]pyrimidinones have been reported as potent antibacterial and antitubercular agents [7,8], and these scaffolds are structurally unrelated to any current clinical antibiotics. Besides this, different side chains introduced into the thieno [2,3-d]pyrimidinone scaffold resulted in a large difference in antibacterial activities.…”

Indole/isatin‐containing hybrids as potential antibacterial agents

“…[ 118,119 ] Moreover, many pyrrole/furan/thiophene‐containing derivatives, such as cefoxitin and temocillin, are common antibacterial agents used in clinics. [ 120 ] Accordingly, hybridization of indole/isatin with pyrrole/furan/thiophene pharmacophore represents an effective strategy to afford antibacterial candidates with high activity.…”

Design, Synthesis and Biological Assessment of Thiazole Derivatives as Possible Antioxidant and Antimicrobial Agents

“…As a result, it is critical to investigate novel scaffolds for the development of new antimicrobials to overcome bacterial resistance and establish effective treatments [6]. A critical part of the drug development program to search for new ways is the synthesis of novel compounds that relate to existing molecules via the presence of certain key structural characteristics [7][8].…”