Thiophene-based vitronectin receptor antagonists

Thiophene and benzodioxole appended thiazolyl-pyrazoline compounds: Microwave assisted synthesis, antimicrobial and molecular docking studies

“…19 In addition, thiophene ring containing compounds exhibit different biological activities such as SGLT2 inhibitors, 20 antitumor, 21 antimicrobial, 22 DHODH inhibitors, 23 BACE1 inhibitors, 24 antioxidant, 25 c-Jun-N-terminal kinase inhibitor, 26 5-HT2A receptor antagonists, 27 anti-inflammatory 28 and vitronectin receptor antagonists. 29 In addition, 1,3-dioxolane ring containing compounds exhibit different biological activities such as antifungal, plant growth regulator, 30 and VLA-4 antagonists. 31 Our goal in this work was to incorporate these four independently biologically active moieties into one molecule to generate compounds with better biological activities.…”