Thioperamide delays vestibular compensation in goldfish

Piratello, Aline Cristina; Mattioli, Rosana

doi:10.1016/j.neulet.2007.01.003

Cited by 4 publications

(6 citation statements)

References 20 publications

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“…In another study, it was shown that the body tilt of animals treated with thioperamide decreased from the 13th day on, while the animals treated with saline presented a significant reduction on the 7th day of treatment. These data suggest that lower histamine levels delayed the process of functional recovery in goldfish (15).…”

Section: Introductionmentioning

confidence: 69%

“…Some studies indicate that the CHS has an important role in the synaptic plasticity and CNS functional recovery, but these data are controversial. Piratello and Mattioli (14,15) showed that the CPA accelerated the functional recovery process in fish after a vestibular system lesion, while Weiler et al (12) found that a central injection of histidine accelerated recovery in mice after unilateral lesion in the TMN region. The blockade of histamine H 1 receptors may play a role in spatial cognition, impairing the acquisition of memory in rats evaluated in an 8-arm radial maze (25).…”

Section: Discussionmentioning

confidence: 99%

“…This dose have been shown to be effective for fish in several models of learning and memory in our laboratory (11,14,15). The saline solution was used as experimental control.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

“…Much research has been done to investigate the influences of the central histaminergic system (CHS) on CNS functions. Among them are circadian rhythm (2), anxiety (3)(4)(5), pain perception (6), locomotor activity modulation (7), learning and memory processes (8)(9)(10)(11), synaptic plasticity, and CNS functional recovery (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Garção

Canto-de-Souza

Romaguera

et al. 2009

Braz J Med Biol Res

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We determined the effect of an H 1 receptor antagonist on the functional recovery of Carassius auratus submitted to telencephalic ablation. Five days after surgery the fish underwent a spatial-choice learning paradigm test. The fish, weighing 6-12 g, were divided into four groups: telencephalic ablation (A) or sham lesion (S) and saline (SAL) or chlorpheniramine (CPA, ip, 16 mg/kg). For eight consecutive days each animal was trained individually in sessions separated by 24 h (alternate days). Training trials (T1-T8) consisted of finding the food in one of the feeders, which were randomly blocked for each subject. Animals received an intraperitoneal injection of SAL or CPA 10 min after the training trials. The time spent by the animals in each group to find the food (latency) was analyzed separately at T1 and T8 by the Kruskal-Wallis test, followed by the Student Newman-Keuls test. At T1 the latencies (mean ± SEM) of the A-SAL (586.3 ± 13.6) and A-CPA (600 ± 0) groups were significantly longer than those of the S-SAL (226.14 ± 61.15) and S-CPA (356.33 ± 68.8) groups. At T8, the latencies of the A-CPA group (510.11 ± 62.2) remained higher than those of the other groups, all of which showed significantly shorter latencies (A-SAL = 301.91 ± 78.32; S-CPA = 191.58 ± 73.03; S-SAL = 90.28 ± 41) compared with T1. These results support evidence that training can lead to functional recovery of spatial-choice learning in telencephalonless fish and also that the antagonist of the H 1 receptor impairs it.

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Section: Introductionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

“…This dose have been shown to be effective for fish in several models of learning and memory in our laboratory (11,14,15). The saline solution was used as experimental control.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Garção

Canto-de-Souza

Romaguera

et al. 2009

Braz J Med Biol Res

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“…pré-T1 em camundongos no WATANABE et al, 1984). (MOBARAKEH et al, 2000); neuroproteção (BRAVO et al, 2008); plasticidade e recuperação funcional (FAGANELLO;PIRATELLO;. Esse neurotransmissor também está envolvido nos comportamentos relacionados à ansiedade (ZARRINDAST et al, 2008), aprendizagem e memória (DAI et al, 2007;MEDALHA et al, 2000), processos especialmente influenciados pelo componente emocional.…”

Section: 5unclassified

Histamina intra-amídala modula a memória aversiva de camundongos submetidos à esquiva inibitória, mas não à reexposição no LCE

Pitta¹

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À professora e orientadora Rosana Mattioli pela oportunidade concedida desde a Iniciação científica, pela confiança, pelo conhecimento construído mutuamente, pela amizade e por ter me dedicado sua "maternidade acadêmica" durante minha formação profissional. À banca examinadora pela atenção dispensada na leitura deste trabalho. Aos meus pais, em especial minha mãe Elena pelo exemplo de determinação, apoio incondicional e pelo amor dedicado sempre! À minha irmã Cota pela amizade, parceria, pela arte e criatividade. Aos meus amigos e colegas das Neurociências Kelly, Carol, Lucas, Jorge, Nadiesca e Diogo pelos momentos compartilhados de apoio, pelas sugestões, pelos conselhos, pela descontração e risadas sempre bem vindas. À Teresa pelo auxílio técnico e experiência compartilhada. Aos amigos que conquistei desde minha vinda a São Carlos, aqueles que dividem comigo as alegrias e as amarguras da vida acadêmica, os que dividem comigo o gosto pela Biologia, aqueles que me acompanham lado a lado desfrutando as boas experiências da vida. Os levarei por toda minha existência! À Silmary por me devolver o ponto de equilíbrio nos momentos decisivos e por me mostrar que "Tudo é uma questão de manter a mente quieta, a espinha ereta e o coração tranquilo". Aos amigos e colegas do Laboratório de Psicologia da Aprendizagem (LPA) pela companhia e apoio. À Profª Azair pela parceria e por compartilhar a infraestrutura do LPA sempre que necessário. À Renata V. Del Moro pelo suporte e auxílio em dúvidas sobre as normas do Programa de Pós em Psicobiologia. Aos funcionários do DFisio pela manutenção das nossas boas condições de trabalho. À FAPESP (Proc. 2010/13362-0) e CNPq pelos auxílios financeiros concedidos durante os dois anos de mestrado.

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Central vestibular compensation: Update

Samy

Elbadry

2011

Audiological Medicine

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Thioperamide delays vestibular compensation in goldfish

Cited by 4 publications

References 20 publications

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Histamina intra-amídala modula a memória aversiva de camundongos submetidos à esquiva inibitória, mas não à reexposição no LCE

Central vestibular compensation: Update

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