1995
DOI: 10.1007/bf03011044
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Thiopentone inhibits beta-adrenergic responses in myocardial tissue

Abstract: The purpose of this study was to determine the importance of inhibition of beta-adrenergic function in thiopentone-induced myocardial depression. Using an isolated, electrically stimulated rat left atria model, contractile dose-response curves to thiopentone (200 microM, 400 microM, 600 microM, 800 microM) were shifted to the right in preparations treated with 10(-3)M dibutyryl cyclic adenosine monophosphate (cAMP) compared with atria stimulated with 10(-6) M dibutyryl cyclic isoprenaline, demonstrating that i… Show more

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Cited by 3 publications
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“…These effects are stereoselective, indicating a receptor‐based mechanism of action [28]. Interference with β‐adrenergic tone has been demonstrated to be partly responsible [29]. Thiopentone also markedly potentiates α1‐and β‐adrenergic arrhythmogenicity in myocardium [30].…”
Section: Gaba(a) Receptorsmentioning
confidence: 99%
“…These effects are stereoselective, indicating a receptor‐based mechanism of action [28]. Interference with β‐adrenergic tone has been demonstrated to be partly responsible [29]. Thiopentone also markedly potentiates α1‐and β‐adrenergic arrhythmogenicity in myocardium [30].…”
Section: Gaba(a) Receptorsmentioning
confidence: 99%