Thiopentone and propofol: a compatible mixture?

Paw, Henry; Garrood, Martin; Fillery-Travis, Annette; Rich, Gillian T.

doi:10.1097/00003643-199807000-00005

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…At pH 7.0, the current was reduced to 86%; at pH 7.4, the current was reduced to 61%; and at pH 8.0, the current was reduced to 56%. *, p < 0.05. pental reduced the pain on injection of propofol more effectively than did lidocaine (Lee et al 1994;Paw et al 1998;Jones et al 1999). In these cases, the local concentration of the barbiturate may be high enough to suppress the purinergic responses at peripheral nerve endings in the vein wall.…”

Section: Discussionmentioning

confidence: 99%

Effects of pentobarbital on purinergic P2X receptors of rat dorsal root ganglion neurons

Kitahara¹,

Yamashita²,

Ikemoto³

2003

Can. J. Physiol. Pharmacol.

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Purinergic P2X receptors are ligand-gated ion channels that are activated by extracellular adenosine triphosphate (ATP) and are widely expressed not only in the central and peripheral nervous system but also in tissues throughout the body, playing an important role in the transfer of nociceptive information. Since the influence of barbiturates on P2X receptor subtypes is not known, we studied the effects of pentobarbital sodium (PB) on ATP responses in dorsal root ganglion (DRG) neurons. DRG neurons were dissected from 10- to 14-day-old rats and dissociated after enzyme treatment. Electrical measurements were performed using the nystatin-perforated patch recording mode under voltage-clamp conditions. Drugs were applied using the Y-tube method. ATP evoked three types of inward current at -60 mV: fast desensitizing, slow desensitizing, and mixed. The fast-type current was attributed to activation of P2X3 subtype and the slow type to the P2X2 subtype. PB suppressed the fast-type current in a concentration-dependent manner, while the slow type was slightly reduced. A noncompetitive inhibition was suggested by a downward shift of the ATP concentration-response curves. The current-voltage relationships showed inward rectification, and the extent of suppression was not affected by the holding potential. The reduction was greater in external solutions of higher pH. PB had subtype-specific effects on P2X receptors. The ionized form is likely to be responsible for the suppression of the P2X3 receptor current, which may result in a reduction of the excitability of central and peripheral neurons and may contribute to the anesthetic and analgesic actions of the agent.

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Section: Discussionmentioning

confidence: 99%

Effects of pentobarbital on purinergic P2X receptors of rat dorsal root ganglion neurons

Kitahara¹,

Yamashita²,

Ikemoto³

2003

Can. J. Physiol. Pharmacol.

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“…According to a hypothesis, its reduction causes the propofol solution to migrate to the fat phase and reduces the amount of propofol in the aqueous phase, thereby reducing pain. [37] Soltani Mohammadi et al [28] conducted a study concluded that adding thiopental to propofol reduced pain caused by intravenous propofol injection.Studies on the physicochemical properties of the propofol-thiopental mixture have proven the compatibility of this combination, and found no trace of instability [41][42][43][44][45] . Anil Agarwal et al [11] conducted a study on pretreatment with thiopentone for prevention of pain associated with propofol injection.…”

Section: Introductionmentioning

confidence: 91%

Attenuation of propofol induced pain by thiopentone sodium, fentanyl and lignocaine: A comparative study

David¹

2023

Int. J. Med. Anesthesiology

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Propofol is one of the most popular intravenous anaesthetic used for induction and maintenance of anaesthesia and sedation in and outside of operating room. Its role is valuable especially for day care surgeries and with larngeal mask airways. Because of high incidence of pain on propofol injection (POPI) numerous interventions have been tested to prevent this pain including the use of different drugs and physical measures as well as the combination of methods. In this. study the effect of pretreatment with thiopentone sodium, preservative free fentanyl, and preservative free 2% lignocaine on reducing propofol induced pain with 4 point pain scale. A prospective observational study was conducted in Government Medical College, Kottayam in 63 patients (ASA 1 and 2) in the age group of 18-60 years scheduled for elective surgery under general anaesthesia. Selected patients were allocated into 3 groups: Group T, Group F and Group L. Prior to propofol injection, Group T received thiopentone sodium 0.5mg/kg, Group F received preservative free fentanyl 2 mcg/kg and Group L received preservative free lignocaine 1 mg/kg and pain on propofol injection was assessed during induction of anaesthesia. All patients post induction received standard general anaesthesia. The lowest incidences of pain on propofol injection were observed in Group T, whereas Group L and Group F shown the same incidences of pain on propofol injection. There were no statistically significant differences in the pain perceived between three groups, group L, group F and group T (47.7 v/s 47.7% v/s 33.3%, p=0.170) on propofol injection. Thiopentone sodium was not significantly different from lignocaine for reducing pain during injection of propofol in this study. Fentanyl is equally effective as lignocaine in reducing such pain. The pretreatment with preservative free fentanyl and thiopentone sodium reduced the incidence of propofol induced pain similar to preservative free 2% lignocaine.

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