Thiopental and halothane dose-sparing effects of magnesium sulphate in dogs

Anagnostou, Τ.; Savvas, Ioannis; Kazakos, George; Raptopoulos, D.; Ververidis, H.N.; Roubies, N.

doi:10.1111/j.1467-2995.2007.00359.x

Cited by 12 publications

(29 citation statements)

References 30 publications

(32 reference statements)

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“…In dogs undergoing elective surgery, MgSO 4 infusion at a rate of 12 mg/kg/h decreased halothane requirements by approximately 22% while increasing serum Mg concentrations by approximately 58%. 17 In the present study, no significant volatile anesthetic-sparing effect was evident despite a 71% increase in blood Mg concentrations. Additionally, the dose-sparing relationship of Mg and propofol has been evaluated in several studies.…”

Section: Discussionmentioning

confidence: 54%

“…Many of the reports describing the anestheticsparing effects of MgSO 4 in humans and dogs are based on clinical endpoints, such as changes in blood pressure, respiratory rate, and heart rate in patients undergoing surgical procedures. 8,10,17 Thus, results of those studies may have been influenced by the combined effects of multiple agents, including inhalational anesthetics, opioids, γ-aminobutyric acid agonists, and neuromuscular blockers; each of these drugs could have resulted in an additive or synergistic effect with Mg. Other factors may include differences in methods among studies, species differences, and the type of inhalation anesthetic used. For instance, MgSO 4 infusion (12 mg/kg/h) significantly reduced the requirement for halothane in dogs undergoing elective ovariohysterectomy in 1 study, 17 but a higher administration rate (15 mg/kg/h) failed to reduce the isoflurane requirement in dogs undergoing a similar surgical procedure 29 and did not change the MAC of isoflurane in goats.…”

Section: Discussionmentioning

confidence: 98%

“…In dogs undergoing elective surgery, infusion of MgSO 4 at a rate of 12 mg/kg/h increased serum Mg concentrations and resulted in a decreased requirement for halothane. 17 A volatile anesthetic-sparing effect of MgSO 4 has been detected in multiple studies. The MAC of desflurane in humans was decreased by 24% following MgSO 4 infusion at a rate of 10 mg/kg/h.…”

Section: Discussionmentioning

confidence: 98%

“…17 Infusion of MgSO 4 at a rate of 10 mg/kg/h to humans undergoing cholecystectomy resulted in a 2-fold increase in serum Mg concentrations and was associated with a decrease in desflurane MAC of 20%. 6 In another study, 8 MgSO 4 infusion at a rate of 8 mg/kg/h decreased propofol dose requirements by 50% and resulted in a 35% increase in baseline serum Mg concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…In dogs undergoing ovariohysterectomy, dose requirements of halothane and thiopental were decreased following anesthetic premedication and intraoperative infusion of MgSO 4 . 17 The anesthetic-and analgesic-sparing properties of Mg have been attributed primarily to its antagonism of the N-methyl-d-aspartate receptor 2 ; thus, Mg may potentiate the effect of other agents (including volatile anesthetics, propofol, and ketamine) that act on the same receptor. [18][19][20] On the basis of the proposed anesthetic-sparing mechanism of Mg and the reports of its volatile anesthetic-and propofol-sparing effects in humans, the objective of the study reported here was to evaluate the effects of IV administration of MgSO 4 , alone and in combination with propofol, on the MAC NM in sevoflurane-anesthetized dogs.…”

mentioning

confidence: 99%

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Effects of magnesium sulfate and propofol on the minimum alveolar concentration preventing motor movement in sevoflurane-anesthetized dogs

Johnson¹,

Seddighi²,

Rohrbach³

et al. 2016

ajvr

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OBJECTIVE To evaluate the effect of MgSO4, alone and in combination with propofol, on the minimum alveolar concentration preventing motor movement (MACNM) in sevoflurane-anesthetized dogs. ANIMALS 6 healthy purpose-bred adult male Beagles (least squares mean ± SEM body weight, 12.0 ± 1.1 kg). PROCEDURES Dogs were anesthetized 3 times at weekly intervals. The MACNM was measured 45 minutes after induction of anesthesia (baseline; MACNM-B) and was determined each time by use of a noxious electrical stimulus. Treatments were administered as a loading dose and constant rate infusion (CRI) as follows: treatment 1, MgSO4 loading dose of 45 mg/kg and CRI of 15 mg/kg/h; treatment 2, propofol loading dose of 4 mg/kg and CRI of 9 mg/kg/h; and treatment 3, MgSO4 and propofol combination (same doses used previously for each drug). A mixed-model ANOVA and Tukey-Kramer tests were used to determine effects of each treatment on the percentage decrease from MACNM-B. Data were reported as least squares mean ± SEM values. RESULTS Decrease from MACNM-B was 3.4 ± 3.1%, 48.3 ± 3.1%, and 50.3 ± 3.1%, for treatments 1, 2, and 3, respectively. The decrease for treatments 2 and 3 was significantly different from that for treatment 1; however, no significant difference existed between results for treatments 2 and 3. CONCLUSIONS AND CLINICAL RELEVANCE MgSO4 did not affect MACNM, nor did it potentiate the effects of propofol on MACNM. Administration of MgSO4 in this study appeared to provide no clinical advantage as an anesthetic adjuvant.

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Section: Discussionmentioning

confidence: 54%