Thionine-functionalized three-dimensional carbon nanomaterial-based aptasensor for analysis of Aβ oligomers in serum

Tao, Dan; Xie, Chunhong; Fu, Sinan; Rong, Shuang; Song, Shizhen; Ye, Huarong; Jaffrézic‐Renault, Nicole; Guo, Zhenzhong

doi:10.1016/j.aca.2021.338990

Cited by 19 publications

(2 citation statements)

References 27 publications

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“…During the fabrication of aptamer‐based electrochemical biosensors (defined as electrochemical aptasensors), researchers found that the incorporation of aptamers with graphene facilitated the biosensors to gain sensitive and selective electrochemical signal toward the target molecules [116]. In this way, the fabricated graphene‐based aptasensors exhibited a broad linearity, low limit of detection and high sensitivity for the detection of biomarkers (such as Glycated albumin [117], Acute myocardial infarction [118], Aβ oligomers [108b], cardiac troponin I [119]).…”

Section: Fabrication Of Graphene‐based Biosensorsmentioning

confidence: 99%

Recent advances on the development of graphene‐based field‐effect transistors, electrochemical biosensors and electrochemiluminescence biosensors

Zhang

Chen

et al. 2023

Electroanalysis

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Graphene, a honeycomb lattice of carbon material with single‐atom‐layer structure, demonstrates extraordinary mechanical, thermal, chemical and electronic properties. Thus, it has sparked tremendous interests in various fields, such as energy storage and conversion devices, field‐effect transistors (FET), chemical sensors and biosensors. In this review, we will first focus on the synthesis method of graphene and the fabrication strategy of graphene‐based materials. Subsequently, the construction of graphene‐based biosensors are introduced, in which three kinds of biosensors are discussed in details, including the FET, electrochemical biosensors and electrochemiluminescence (ECL) biosensors. The performances of the state‐of‐the‐art biosensors on the detection of biomolecules are also displayed. Finally, we also highlight some critical challenges remain to be solved and the development in this field for further research.

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Section: Fabrication Of Graphene‐based Biosensorsmentioning

confidence: 99%

Recent advances on the development of graphene‐based field‐effect transistors, electrochemical biosensors and electrochemiluminescence biosensors

Zhang

Chen

et al. 2023

Electroanalysis

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“…In a further example, an analytical signal was amplified by including three-dimensional carbon nanomaterials (rGO and multiwalled carbon nanotubes (MWCNTs)) in a sensing platform [122]. AβOs were detected using a voltammetric aptasensor based on an rGO-MWCNT nanocomposite functionalized with thionine (Thi).…”

Section: Amyloid β Peptidementioning

confidence: 99%

An Overview of the Latest Developments in the Electrochemical Aptasensing of Neurodegenerative Diseases

Mikuła

Malecka-Baturo

2023

Coatings

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Neurodegenerative diseases (NDs) are becoming a major global health problem. They constitute an incurable diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous system. There is an enormous unmet demand worldwide for methods for the early detection of ND biomarkers. The complexity of the molecular mechanisms underlying neuronal degeneration as well as the inhomogeneity of the patient population pose a great challenge for the development of early diagnostic tools. Various analytical technologies have been developed to meet this challenge. Among the various approaches reported so far, biosensors are powerful analytical implements that have been applied to detect biomarkers of NDs. Over the past decade, electrochemical aptasensors have been at the forefront of this development not only thanks to their low cost and simple design but also due to advances in nanomaterials modifying the surface of the transducers involved. The design of electrochemical aptasensors for the detection of ND biomarkers such as α-synuclein, amyloid β peptide, tau protein and human cellular prion protein were summarized and compared. Innovative strategies for increasing their sensitivity and selectivity were also pointed out. Undoubtedly, there is still a need for low-cost, fast and easy-to-use systems for the early detection of NDs.

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Loading thionine onto MXene enhances electron transfer and ultrasensitive electrochemical detection of H₂O₂

Dong,

Sun,

Liu

et al. 2024

J Chinese Chemical Soc

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As an important reactive oxygen species (ROS) signal molecule in plant physiological regulation, H2O2 maintains cellular homeostasis through concentration regulation. It is worth paying attention to the concentration imbalance of H2O2 caused by various stresses, resulting in programed cell death or even developmental arrest in plants. To accurately quantify alterations in H2O2 concentration induced by these stress factors, and deeply understand the H2O2‐related physiological processes, a highly efficient hybrid electrode material of thionine@Ti3C2Tx (Th@MXene) composite was developed. MXene nanosheets not only performed as carriers with high specific surface area for loading Th but also contributed to the enhancement of electrical conductivity. Meanwhile, Th was uniformly loaded on the MXene surface, facilitating electron transport from the analyte to the modified electrode. Under the optimal detection conditions, the sensing electrode (Th@MXene/GCE) was employed to quantify H2O2 through Square‐wave Voltammetry signals with a good linear relationship (correlation coefficient is 0.9997), and a wide calibration range of the sensor was 0.1 to 10,000 nM. Above all, the detection limit can be as low as 34 pM, demonstrating excellent sensitivity. Additionally, the sensor exhibited repeatability in real samples, demonstrating exceptional practicality.

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Thionine-functionalized three-dimensional carbon nanomaterial-based aptasensor for analysis of Aβ oligomers in serum

Cited by 19 publications

References 27 publications

Recent advances on the development of graphene‐based field‐effect transistors, electrochemical biosensors and electrochemiluminescence biosensors

Recent advances on the development of graphene‐based field‐effect transistors, electrochemical biosensors and electrochemiluminescence biosensors

An Overview of the Latest Developments in the Electrochemical Aptasensing of Neurodegenerative Diseases

Loading thionine onto MXene enhances electron transfer and ultrasensitive electrochemical detection of H₂O₂

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Thionine-functionalized three-dimensional carbon nanomaterial-based aptasensor for analysis of Aβ oligomers in serum

Cited by 19 publications

References 27 publications

Recent advances on the development of graphene‐based field‐effect transistors, electrochemical biosensors and electrochemiluminescence biosensors

Recent advances on the development of graphene‐based field‐effect transistors, electrochemical biosensors and electrochemiluminescence biosensors

An Overview of the Latest Developments in the Electrochemical Aptasensing of Neurodegenerative Diseases

Loading thionine onto MXene enhances electron transfer and ultrasensitive electrochemical detection of H2O2

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Product

Resources

About

Loading thionine onto MXene enhances electron transfer and ultrasensitive electrochemical detection of H₂O₂