Thiolated silicone oils as adhesive skin protectants for improved barrier function

Partenhauser, Alexandra; Zupančič, Ožbej; Rohrer, Julia; Bonengel, Sonja; Bernkop‐Schnürch, Andreas

doi:10.1111/ics.12284

Cited by 13 publications

(30 citation statements)

References 30 publications

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“…Taking the theoretically maximum thiol coupling of 227 µmol/g into account, an almost quantitative coupling of MPA and TGA above 96% is evident. The results are corresponding with previously synthesized thiolated silicone oil . Preactivated silicone oil was designed for the first time within this study, whereby nearly half of all free thiol groups were covalently coupled to 2‐MNA for both silicone‐TGA and silicone‐MPA (Table ).…”

Section: Resultssupporting

confidence: 55%

“…Thiol ligands presumably have a decisive influence on the thiomer's properties apart from other parameters such as total amount of immobilized thiol groups. This presumption is supported by a dermatological study with both silicone‐TGA and silicone‐MPA . Thiolated silicone oils were preactivated via oxidative S–S coupling of 2‐MNA to free thiol groups on the silicone's backbone (Figure ).…”

Section: Discussionmentioning

confidence: 83%

“…The results are corresponding with previously synthesized thiolated silicone oil. 23,31 Preactivated silicone oil was designed for the first time within this study, whereby nearly half of all free thiol groups were covalently coupled to 2-MNA for both silicone-TGA and silicone-MPA (Table I).…”

Section: Characterization Of Preactivated and Thiolated Silicone Oilsmentioning

confidence: 99%

“…This presumption is supported by a dermatological study with both silicone-TGA and silicone-MPA. 31 Thiolated silicone oils were preactivated via oxidative S-S coupling of 2-MNA to free thiol groups on the silicone's backbone (Figure 1). This concept has already been described for hydrophilic polymers, such as poly (acrylic acid).…”

Section: Characterization Of Preactivated and Thiolated Silicone Oilsmentioning

confidence: 99%

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Preactivated silicone oil as potential long-term vitreous replacement with nonemulsifying properties

Partenhauser

Netsomboon

Sousa

et al. 2015

J. Biomed. Mater. Res.

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Preactivated silicone oils tackle the shortcomings of currently available silicone oils as they unite suitable handling qualities with a resistance against emulsification, which renders them promising for long-term vitreous replacement. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 551-559, 2017.

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Section: Resultssupporting

confidence: 55%

Section: Discussionmentioning

confidence: 83%

Section: Characterization Of Preactivated and Thiolated Silicone Oilsmentioning

confidence: 99%

Section: Characterization Of Preactivated and Thiolated Silicone Oilsmentioning

confidence: 99%

See 2 more Smart Citations

Preactivated silicone oil as potential long-term vitreous replacement with nonemulsifying properties

Partenhauser

Netsomboon

Sousa

et al. 2015

J. Biomed. Mater. Res.

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show abstract

“…Silicones are known to be used in treatment products and in skin protection preparations against skin diseases such as atopic dermatitis (AD) or irritant contact dermatitis (ICD). Moreover, they are safe, non-comedogenic, hypoallergic, and water-resistant [ 8 , 9 , 10 , 11 ]. No interference with stratum corneum lipid organization has been discovered [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases

et al. 2021

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This work investigates the possibility of using thiolated silicone oils as new components in protective creams and their impact on the efficacy of these products. Thiolated silicone oils were synthesized by amide bond formation between primary amino groups of poly17dimethylsiloxane-co-(3-aminopropyl)-methylsiloxane] and carboxylic groups of thiol ligand (3-mercaptopropionic acid) with carbodiimide as a coupling agent. To evaluate and compare the properties of these kinds of thiomers, three different emulsion o/w types were obtained. Emulsion E1 contained methyl silicone oil, E2 poly[dimethylsiloxane-co-(3-aminopropyl)-methylsiloxane], and E3 thiolated silicone oil (silicone-MPA), respectively. Physicochemical properties, including pH, conductivity, droplet size distribution, viscosity, and stability, were assessed. The efficacy of barrier creams in the prevention of occupational skin diseases depends on their mechanical and rheological properties. Thus, the method which imitates the spreadability conditions on the skin and how structure reconstruction takes places was performed. We also investigated textural profile, bioadhesion, protection against water and detergents, and water vapor permeability. Emulsion E3 was characterized by beneficial occlusion, spreadability, and adhesion properties. These features with prolonged residence time on the skin can make designed barrier creams more preferable for consumers.

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Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body

Hock¹,

Racaniello

Aspinall

et al. 2021

Advanced Science

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Advances in nanotechnology have generated a broad range of nanoparticles (NPs) for numerous biomedical applications. Among the various properties of NPs are functionalities being related to thiol substructures. Numerous biological processes that are mediated by cysteine or cystine subunits of proteins representing the workhorses of the bodies can be transferred to NPs. This review focuses on the interface between thiol chemistry and NPs. Pros and cons of different techniques for thiolation of NPs are discussed. Furthermore, the various functionalities gained by thiolation are highlighted. These include overall bio-and mucoadhesive, cellular uptake enhancing, and permeation enhancing properties. Drugs being either covalently attached to thiolated NPs via disulfide bonds or being entrapped in thiolated polymeric NPs that are stabilized via inter-and intrachain crosslinking can be released at the diseased tissue or in target cells under reducing conditions. Moreover, drugs, targeting ligands, biological analytes, and enzymes bearing thiol substructures can be immobilized on noble metal NPs and quantum dots for therapeutic, theranostic, diagnostic, biosensing, and analytical reasons. Within this review a concise summary and analysis of the current knowledge, future directions, and potential clinical use of thiolated NPs are provided.

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Thiolated silicone oils as adhesive skin protectants for improved barrier function

Abstract: Thiolation of silicone oil leads to enhanced skin adhesiveness and barrier function, which is a major advantage compared to commonly used silicones and might thus be a promising treatment modality for various topical applications.

Cited by 13 publications

References 30 publications

Preactivated silicone oil as potential long-term vitreous replacement with nonemulsifying properties

Preactivated silicone oil as potential long-term vitreous replacement with nonemulsifying properties

Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases

Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body

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