Thiolated and PEGylated silica nanoparticle delivery to hair follicles

Mahrooqi, Jamila H. Al; Khutoryanskiy, Vitaliy V.; Williams, Adrian C.

doi:10.1016/j.ijpharm.2020.120130

Cited by 21 publications

(14 citation statements)

References 66 publications

(90 reference statements)

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“…The improved drug permeability through the skin can be achieved by the use of various chemical or physical penetration enhancers applied either alone or in combination . Another possible way to increase the efficiency of intradermal drug transportation is associated with the usage of different drug delivery systems and platforms. , …”

Section: Resultsmentioning

confidence: 99%

“…59 Another possible way to increase the efficiency of intradermal drug transportation is associated with the usage of different drug delivery systems and platforms. 60,61 We have recently developed a novel particulate formulation for Gf utilizing micron-sized vaterite particles. 29,30 This composition ensured the improvement of dermal bioavailability for this antimycotic when topically applied in vivo in rats under sonophoresis.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Cytotoxicity, Dermal Toxicity, and In Vivo Antifungal Effect of Griseofulvin-Loaded Vaterite Carriers Administered via Sonophoresis

et al. 2023

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The search for novel therapeutic strategies to treat fungal diseases is of special importance nowadays given the emerging threat of drug resistance. Various particulate delivery systems are extensively being developing to enhance bioavailability, site-specific penetration, and therapeutic efficacy of antimycotics. Recently, we have designed a novel topical formulation for griseofulvin (Gf) drug, which is currently commercially available in oral dosage forms due to its limited skin permeation. The proposed formulation is based on vaterite carriers that enabled effective incorporation and ultrasonically assisted delivery of Gf to hair follicles improving its dermal bioavailability. Here, we evaluated the effect of ultrasound on the viability of murine fibroblasts co-incubated with either Gf-loaded carriers or a free form of Gf and investigated the influence of both forms on different subpopulations of murine blood cells. The study revealed no sufficient cyto- and hemotoxicity of the carriers, even at the highest investigated concentrations. We also conducted a series of in vivo experiments to assess their multi-dose dermal toxicity and antifungal efficiency. Visual and histological examinations of the skin in healthy rabbits showed no obvious adverse effects after US-assisted application of the Gf-loaded carriers. At the same time, investigation of therapeutic efficiency for the designed formulation in comparison with free Gf and isoconazole drugs in a guinea pig model of trichophytosis revealed that the vaterite-based form of Gf provided the most rapid and effective cure of infected animals together with the reduction in therapeutic procedure number. These findings pave the way to improving antifungal therapy of superficial mycoses and justifying further preclinical studies.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Cytotoxicity, Dermal Toxicity, and In Vivo Antifungal Effect of Griseofulvin-Loaded Vaterite Carriers Administered via Sonophoresis

et al. 2023

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“…Meanwhile, choosing PEG as the surface modifier is an efficient way to avoid reticuloendothelial system (RES) recognition because heavily hydrated PEG chains can move rapidly in an aqueous solution, resulting in a stealthy effect and a rejection of hydrophobic proteins. [33][34][35][36] As shown in Figure 1a, FMSNs-PEG nanocarriers had a uniform particle size of about 8 nm. Dynamic light scattering (DLS) results show that the diameters of FMSNs-PEG were 9 nm (Figure 1c).…”

Section: Preparation and Characterization Of Fmsn S -Pegmentioning

confidence: 92%

Polyethylenimine Functionalized Ultrasmall Mesoporous Silica Nanoparticles for siRNA Delivery

Chang

Liu

et al. 2022

ChemNanoMat

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Small interfering RNA (siRNA) for gene therapy has attracted great attention. However, due to easy degradation and inaccessibility to the cells, the gene silencing efficiency is not always satisfactory. To overcome this hurdle, developing an excellent nanocarrier to deliver siRNA into cancer cells is crucial. Fluorescent mesoporous silica nanoparticles are considered to be a superb nanocarrier for siRNA delivery systems because of its negligible toxicity and good biocompatibility. Herein, we developed an efficient fluorescent ultrasmall mesoporous silica nanocarrier for siRNA loading and delivery. The ultrasmall nanocarriers with polyethyleni-mine coating have a uniform size of about 10 nm. We find that the amino groups on polyethylenimine can protect siRNA from being degraded. Based on the fluorescence observation, we show that polyethylenimine-coated mesoporous silica nanocarrier loaded with siRNA can be uptake by 293T cells. Importantly, we also prove that siRNA can be delivered into 293T cells by our nanocarrier and subsequently inhibit the expression of related genes. The study provides insights into the development of nonviral fluorescence nanocarriers for siRNA delivery, which have important implications for targeted cancer therapy.

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Section: Introductionmentioning

confidence: 99%

“…18 However, the size of a drug carrier imposes a limitation on available delivery routes and currently, it is clear that the enlargement of a drug vehicle size results in prevailing transappendageal penetration. [19][20][21][22][23][24] In this context, intrafollicular drug administration has attracted more attention recently. 25,26 Hair follicles represent the reservoir extending deep into the dermis, which is characterized by a large surface area available for drug absorption.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable calcium carbonate carriers for the topical delivery of clobetasol propionate

Saveleva,

Verkhovskii,

Demina

et al. 2024

J. Mater. Chem. B

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Thiolated and PEGylated silica nanoparticle delivery to hair follicles

Cited by 21 publications

References 66 publications

Cytotoxicity, Dermal Toxicity, and In Vivo Antifungal Effect of Griseofulvin-Loaded Vaterite Carriers Administered via Sonophoresis

Cytotoxicity, Dermal Toxicity, and In Vivo Antifungal Effect of Griseofulvin-Loaded Vaterite Carriers Administered via Sonophoresis

Polyethylenimine Functionalized Ultrasmall Mesoporous Silica Nanoparticles for siRNA Delivery

Biodegradable calcium carbonate carriers for the topical delivery of clobetasol propionate

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