Thiol/disulphide homeostasis in men with heroin addiction

Kotan, Vahap Ozan; Yılmaz, Fatma Meriç; Neşeli̇oğlu, Salim; Erel, Özcan; Okay, İhsan Tuncer; Kiral, Serkan; Bakirhan, Abdurrahim; Göka, Erol

doi:10.5350/dajpn2017300203

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…In a case-control study conducted by Kotan et al . [ 27 ] on heroin addicts, native thiol and total thiol levels were found to be significantly lower in the patient group compared to the CG, while disulfide levels were found to be higher. The duration of substance use was, however, reported not to be significantly associated with these variables [ 27 ].…”

Section: Discussionmentioning

confidence: 96%

“…[ 27 ] on heroin addicts, native thiol and total thiol levels were found to be significantly lower in the patient group compared to the CG, while disulfide levels were found to be higher. The duration of substance use was, however, reported not to be significantly associated with these variables [ 27 ]. In studies conducted with patients using cannabis and synthetic cannabinoids, an increase in inflammation and oxidative stress has been reported [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

Turan

Şenormancı

Neşeli̇oğlu

et al. 2023

Clin Psychopharmacol Neurosci

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Objective This study aimed to investigate the blood serum levels of biomarkers specifying oxidative stress status and systemic inflammation between people using methamphetamine (METH) and the control group (CG). Serum thiol/disulfide balance and ischemia-modified albumin levels were studied to determine oxidative stress, and serum interleukin-6 (IL-6) levels and complete blood count (CBC) were to assess inflammation. Methods Fifty patients with METH use disorder (MUD) and 36 CG participants were included in the study. Two tubes of venous blood samples were taken to measure oxidative stress, serum thiol/disulfide balance, ischemia-modified albumin, and IL-6 levels between groups. The correlation of parameters measuring oxidative stress and inflammation between groups with sociodemographic data was investigated. Results In this study, serum total thiol, free thiol levels, disulfide/native thiol percentage ratios, and serum ischemia-modified albumin levels of the patients were statistically significantly higher than the healthy controls. No difference was observed between the groups in serum disulfide levels and serum IL-6 levels. Considering the regression analysis, only the duration of substance use was a statistically significant factor in explaining serum IL-6 levels. The parameters showing inflammation in the CBC were significantly higher in the patients than in the CG. Conclusion CBC can be used to evaluate systemic inflammation in patients with MUD. Parameters measuring thiol/disulfide homeostasis and ischemia-modified albumin can be, also, used to assess oxidative stress.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

Turan

Şenormancı

Neşeli̇oğlu

et al. 2023

Clin Psychopharmacol Neurosci

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Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review

Tuncay

Atagün

Erel

2023

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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A comprehensive study of oxidative stress in patients with somatic symptom disorder

Şahin

Çayköylü

Senat

et al. 2018

Acta Neuropsychiatr.

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ObjectiveTo investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Statistical Manual of Mental Disorders-5.MethodsThe study included 41 medication-free patients with somatic symptom disorder and 47 age, sex, and sociodemographic-matched healthy individuals. The patients were administered the Patient Health Questionnaire-15, Somatic Symptom Amplification Scale, Beck Depression Inventory, and Beck Anxiety Inventory. TOS, TAS, OSI, PON, ARE thiol, disulphide levels, and routine biochemical parameters were compared between the two groups.ResultsTOS, OSI, disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios were found significantly higher in the patient group compared with the control group (p < 0.001). There was no significant difference in PON, ARE, and TAS parameters between the two groups (p > 0.05).ConclusionThis study showed that the level of oxidants increased and oxidative balance was impaired in somatic symptom disorder. Oxidative stress may play a role in the aetiopathogenesis of this disorder. This is the first study to report an association between oxidative stress and somatic symptom disorder.

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Thiol/disulphide homeostasis in men with heroin addiction

Cited by 4 publications

References 23 publications

Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review

A comprehensive study of oxidative stress in patients with somatic symptom disorder

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