Thiol–disulfide homeostasis and ischemia‐modified albumin as a marker of oxidative stress in patients with sarcopenia

Abstract

Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. Chronic inflammatory conditions and increased oxidative stress are in the pathogenesis of sarcopenia. Our aim was to evaluate the relationship between sarcopenia and thiol-disulfide homeostasis and ischemia-modified albumin levels as an oxidative stress marker.Methods: Patients aged ≥65 years were recruited in this study. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People criterion. Total thiol, native thiol, disulfide and ischemia-modified albumin levels were measures according to clinical and laboratory features. Patients were divided into two groups according to their sarcopenia presence; thiol-disulfide homeostasis and ischemia-modified albumin levels were evaluated between these groups.Results: Overall, 94 patients were analyzed. The mean age was 75.0 AE 6.71 years. A total of 39% of the patients were diagnosed as probable sarcopenia, 3.2% had sarcopenia, 6.4% had severe sarcopenia and 51.1% were diagnosed as normal. The levels of native thiol, total thiol, disulfide level and disulfide-native thiol, native thiol-total thiol and disulfide-total thiol ratios were similar in patients with sarcopenia when compared with the control group. In addition, there were no differences between albumin and ischemia-modified albumin levels. In univariate regression analysis, handgrip strength was found to be an independent predictor of native thiol and total thiol, and disulfide levels. Conclusion:This is the first study in the literature that evaluates the thiol-disulfide homeostasis and ischemia-modified albumin levels in sarcopenic older patients. Long-term studies are warranted to confirm the relationship between oxidative stress markers and sarcopenia.

Sarcopenia and nutritional status are associated with Severe Postoperative Complications in Gastric Cancer Patients: A Multicenter Study

“…Moreover, Erel et al reported that thiol-disul de balance deteriorated in diseases characterized by intense in ammation and oxidative stress, such as hypertension, diabetes, metabolic syndrome and burns 33 . Therefore, although the albumin level of patients with sarcopenia should be lower than that of patients without sarcopenia in theory, it is actually affected by comorbidities and other factors, which has been reported in previous studies 34,35 .…”

Meta-analysis of changes in thiol-disulfide homeostasis during preeclampsia

“…It may be because of the fact that oxidative pathways have been stimulated as the disease progresses, which means that antioxidant effectors, such as thiols, will be depleted to buffer the oxidative stress [ 41 ]. In addition, proteinuria in women with PE leads to albumin loss, and as albumin is the main carrier protein for thiol groups in the plasma, total and native thiol concentrations may reduce subsequently [ 42 ]. These findings may also explain the findings of some previous clinical studies that supplementation with some antioxidants may be effective in reducing the incidence of PE in high-risk women [ 43 , 44 ].…”