Thiol/disulfide homeostasis: A prognostic biomarker for patients with advanced non-small cell lung cancer?

Dirican, Nigar; Dirican, Ahmet; Şen, Orhan; Aynalı, Ayşe; Atalay, Sule; Bircan, Hacı Ahmet; Öztürk, Önder; Erdoğan, Serpil; Çakır, Münire; Akkaya, Ahmet

doi:10.1179/1351000215y.0000000027

Cited by 79 publications

(83 citation statements)

References 31 publications

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“…In their preliminary studies, they reported that increased thiol and decreased disulphide levels were associated with proliferated diseases, such as multiple myeloma and malignancies, whereas decreased thiol levels and increased disulphide levels were associated with degenerative diseases, such as diabetes, obesity, pneumonia and smoking. [30][31][32] However, our results showed that dynamic thiol disulphide homeostasis is associated with an increased shift to the reductive side as a proliferative manner, in women diagnosed with major depressive disorder. In our correlation analysis, we found a negative correlation between depression severity and plasma disulphide levels only in the patient group.…”

Section: Anadolu Psikiyatri Derg 2018; 19(2):135-142contrasting

confidence: 47%

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Baykan¹,

Durmaz²,

Baykan³

et al. 2018

Anadolu Psikiyatri Derg

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Section: Anadolu Psikiyatri Derg 2018; 19(2):135-142contrasting

confidence: 47%

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Baykan¹,

Durmaz²,

Baykan³

et al. 2018

Anadolu Psikiyatri Derg

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“…In their preliminary studies, they showed that plasma disulphide levels were higher in patients with degenerative diseases, such as diabetes, smoking, obesity, and pneumonia, and were lower in patients with proliferative diseases, such as multiple myeloma, colon cancer, and renal cancer. [36][37][38] We found lower disulphide levels in patients with FMS compared with the healthy controls. However, we did not observe any difference in total thiol levels between the two groups.…”

Section: Discussionmentioning

confidence: 59%

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

Fidan

Alkan²,

Uğurlu

et al. 2017

Arch Rheumatol

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Objectives: This study aims to investigate dynamic thiol/disulphide homeostasis in patients with fibromyalgia syndrome (FMS). Patients and methods: Fifty female patients with FMS (mean age 40.5±7.2 years; range 21 to 55 years) and 40 healthy female controls (mean age 39±9.4 years, range 22 to 55 years) were included in the study. Pain visual analog scale, tender points, Fibromyalgia Impact Questionnaire, and Beck Depression Inventory were evaluated. Age, body mass index (BMI), and symptom durations were also recorded. Native thiol, disulphide and total thiol levels were measured with a novel automated method. Results: Serum disulphide levels were 14.7±3.4 µmol/L and 22.2±3.6 µmol/L in the FMS and control groups, respectively (p<0.001). Native thiol levels were 452.1±33.8 µmol/L and 433.5±37.6 µmol/L in the FMS and control groups, (p=0.015), while total thiol levels were 481.7±35.6 µmol/L and 477.5±38.9 µmol/L in the FMS and control groups, respectively (p=0.593). In the FMS group, disulphide/native thiol percent ratios and disulphide/ total thiol percent ratios were statistically significantly lower and native/total thiol percent ratios were statistically significantly higher than those of the control group. There were no correlations between serum thiol/disulphide profiles and pain scores & clinical variables in patients with FMS. Conclusion: Because of the decreased disulphide and increased native thiol levels, the thiol/disulphide balance has shifted to the reductive side. This metabolic disturbance may have a role in the pathogenesis of FMS.

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“…Oxidative stress has attracted the interest of clinicians for a long time and it has been shown that it has a critical role in the progress of various diseases such as type 1 diabetes mellitus, cancer, atherosclerosis, and hypertension. [21][22][23][24] Both excessive oxidative stress and inadequate defence of cardiomyocytes can also play a role in the development of early onset of chemotherapy-induced cardiotoxicity. 3) Myocardial cells, a metabolically active tissue, have an elegant system of antioxidant defenses and cell repair mechanisms against oxidative and nitrosative stress which can cause cell necrosis and/or apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

et al. 2017

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SummaryThe aim of the present study was to evaluate whether the baseline thiol/disulfide state can predict the occurrence of anthracycline induced cardiac toxicity. A total of 186 cancer patients receiving anthracycline (doxorubicin)-based chemotherapy were enrolled. All patients underwent 2-dimensional (2D) speckle tracking echocardiography (STE) to determine their left ventricular ejection fraction (LVEF) and blood samples for measuring thiol forms were obtained before treatment and 4 weeks after completion of the chemotherapy. The mean dose of doxorubicin exposure was 255 ± 39.2 mg/m 2 . Baseline native thiol was found to be lower whereas baseline disulfide and the disulfide/total thiol ratio were found to be higher in patients who had a decrease in LVEF after anthracycline therapy. Also, the amount of decrease in LVEF was well correlated with the delta value of the thiol forms. Logistic regression analysis revealed that changes in BNP and global longitudinal strain (GLS), baseline level of native thiol, disulfide, and the disulfide/total thiol ratio were strong predictors for a decrease in LVEF.The thiol/disulfide pathway may be a factor for predicting chemotherapy-induced cardiac toxicity as one of the oxidative stress mechanisms. (Int Heart J 2017; 58: 69-72)

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Thiol/disulfide homeostasis: A prognostic biomarker for patients with advanced non-small cell lung cancer?

Cited by 79 publications

References 31 publications

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

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