Thioether-functionalized cellulose for the fabrication of oxidation-responsive biomaterial coatings and films

Abstract

Biomaterial coatings and films can prevent premature failure and enhance performance of chronically implanted medical devices. However, current hydrophilic polymer coatings and films have significant drawbacks, including swelling and delamination. To address these issues, we modified hydroxyethyl cellulose with thioether groups to generate an oxidation-responsive polymer, HECMTP. HECMTPreadily dissolves in green solvents and can be fabricated as coatings or films with tunable thicknesses. HECMTPcoatings effectively scavenge hydrogen peroxide, resulting in conversion of thioether groups to sulfoxide groups on the polymer chain. Oxidation-driven, hydrophobic-to-hydrophilic transitions that are isolated to the surface of HECMTPcoatings under physiologically relevant conditions increase wettability, decrease stiffness, and reduce protein adsorption to generate a non-fouling interface with minimal coating delamination or swelling. HECMTPcan be used in diverse optical applications and permits oxidation-responsive, controlled drug release. HECMTPfilms are non-resorbablein vivoand evoke minimal foreign body responses. These results highlight the versatility of HECMTPand support its incorporation into chronically implanted medical devices.TeaserModification of cellulose polymer into a non-resorbable, oxidation-responsive biomaterial affords multi-functional coatings and films.