Thiocyanate Therapy in Hypertension

Goldring, William

doi:10.1001/archinte.1932.00150130057003

Cited by 9 publications

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POTASSIUM thiocyanate has been used for some years in America in the treatment of arterial hypertension. Some of the earlier reports of its, value as a therapeutic agent were discouraging because of its toxic effects, but since dosage with the drug has been controlled by serum thiocyanate determinations, its usefulness has become apparent.Thus Goldring and Chassis (1932) administered to patients with hypertension (the dosage was not controlled by serum thiocyanate determinations) and concluded that the fall in blood pressure and the uccurrence of toxic symptoms were unrelated to the dose. Besides, there was it narrow margin between the toxic and therapeutically effective dose of the drug.Barker (1936) gave the drug under conditions of controlled dosage and found that when the concentration of thiocyanate ion in the serum was from 10-15 mg. per cent., there was a significant fall in blood pressure in 35 out of 45gpatients.

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The Treatment of Arterial Hypertension With Potassium Thiocyanate

D'Silva

Evans

1944

British Journal of Urology

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Summary (1) In a series of 25 unselected cases of persistent hypertension treated with potassium thiocyanate, 11 responded by a considerable fall and 6 by a slight fall in blood pressure. In 8 cases the blood pressure was unchanged. Headache, vertigo, and lack of concentration were the associated symptoms most often relieved. (2) The drug was administered safely to elderly patients and those with electrocardiographic evidence of myocardial degeneration. Two cases with cerebral arteriosclerosis benefited greatly by treatment. No patient with severe renal dysfunction was encountered in this series. (3) Two patients were poisoned with the drug but made uneventful recoveries when its administration was suspended.

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confidence: 99%

“…Thus Goldring and Chassis (1932) administered to patients with hypertension (the dosage was not controlled by serum thiocyanate determinations) and concluded that the fall in blood pressure and the uccurrence of toxic symptoms were unrelated to the dose. Besides, there was it narrow margin between the toxic and therapeutically effective dose of the drug.…”

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confidence: 99%