Thioacetamide catalysed transformation of nitriles to 2-substituted imidazolines

Abstract

The reaction of various nitriles with ethylenediamine in presence of thioacetamide as catalyst has been studied.

New cycloplatinated complexes with 2-arylimidazolines: Synthesis, crystal structures and photophysical properties

“…Compounds 1b [12] and 1c [13] were prepared according to literature methods. All the other reagents were used as commercial sources.…”

Green Synthesis of 2‐Substituted Imidazolines using Hydrogen Peroxide Catalyzed by Tungstophosphoric Acid and Tetrabutylammonium Bromide in Water

“…The synthesis of 2‐substituted imidazolines has become of great importance and interest, not only because they are important intermediates but also because they have been found promising applications in many pharmaceutical and synthetic areas . Due to its increasing importance, a series of methods have been developed for the synthesis of 2‐substituted imidazolines starting from nitriles , esters , carboxylic acids , and amides . However, some of these methods involve disadvantages such as harsh reaction conditions and the use of highly toxic cyanide.…”

Efficient and one‐pot catalytic synthesis of 2‐imidazolines and bis‐imidazolines with p‐toluenesulfonic acid under solvent free conditions

“…A good source of C‐1 for preparation of imidazolines is nitriles. Some novel conditions have been developed for this reaction, using Lewis acids, Brönsted acids, or other small molecules as catalysts, such as HCl [13d], CuCl [13e], thioacetamide [23], sulfur [13i], ZrOCl 2 [13j], silica sulfuric acid [24], 12‐tungstophosphoric acid [25], and carbon disulfide [13k].…”