Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils

Abstract

Six new 2-o-(m- and p-)chlorobenzylthio-6-methyl-5-piperidino-(or morpholino-) methyluracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, 1H NMR, 13C NMR, and HMBC) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of prediction of activity spectra for substances (PASS).

Synthesis of new pyrimidine derivatives and their antiproliferative activity against selected human cancer cell lines

“…It has been reported that the tested compounds had comparable activity to that of uracils [3]. From 1957 to 2011, different research laboratories investigated the anticancer activity of some 5-and 6-substituted 2-thiouracils and reported that the tested compounds were found to inhibit DNA synthesis [4][5][6][7][8][9][10][11]. Based on these findings, the present work aims to synthesize a new group of pyrimidine compounds incorporated with different heterocycles to investigate whether the resulting compounds have better biological activity as antiproliferative agents against cancer, since all the selected pyrimidine derivatives were soluble in dimethyl sulfoxide (DMSO) at sufficient concentrations to allow cell experiments.…”