Thinning of cervical nerve roots and peripheral nerves in ALS as measured by sonography

Nodera, Hiroyuki; Takamatsu, Naoko; Shimatani, Yoshimitsu; Mori, Atsuko; Sato, Kengo; Oda, Masaya; Terasawa, Yuka; Izumi, Yuishin; Kaji, Ryuji

doi:10.1016/j.clinph.2014.01.033

Cited by 70 publications

(76 citation statements)

References 18 publications

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“…Intuitively, one may expect reduced CSA in axonal PN due to loss of myelinated fibres. However, this is seldom apparent with the exception of modest reduction of nerve calibre in amyotrophic lateral sclerosis (ALS) 60 65 66. In fact, US of axonal PN may detect nerve enlargement in approximately 20% of patients 15…”

Section: Us Findings In Pnmentioning

confidence: 99%

Ultrasound in the diagnosis of peripheral neuropathy: structure meets function in the neuromuscular clinic

Gallardo

Noto

Simon

2015

J Neurol Neurosurg Psychiatry

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Section: Us Findings In Pnmentioning

confidence: 99%

Ultrasound in the diagnosis of peripheral neuropathy: structure meets function in the neuromuscular clinic

Gallardo

Noto

Simon

2015

J Neurol Neurosurg Psychiatry

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“…At the authors' knowledge, we were the first to report the thinness of cervical nerve roots in ALS and further showed that the diagnostic sensitivity to detect thinness was greater in the cervical nerve roots than the peripheral nerves (median and ulnar nerves) (3). Because the report studied relatively small number of the subjects, further analysis such as correlation with its clinical subtypes was not performed.…”

Section: Sonographic Evaluation Of Peripheral Nerves In Als and Relatmentioning

confidence: 99%

“…For imaging of the cervical nerve roots, a coronal oblique plane was used to visualize the cervical nerve roots longitudinally. By using the previously described methods the right C5, C6, and C7 nerve roots were easily identified (3,9). To obtain optimal images for measurements of maximal diameter, the cervical nerve roots were examined in the sagittal oblique plane in addition to the coronal oblique plane in some cases.…”

Section: Sonographymentioning

confidence: 99%

“…Schreiber and colleagues reported thinning of ulnar nerves in different subtypes of ALS, primarily based on the involvement of the upper and lower motor neurons (4). Because evaluation of cervical roots might provide information in the proximal muscles innervated by C5, C6, and C7 nerve roots, sonographic evaluation of peripheral nerve (e.g., median and ulnar nerves) as well as cervical nerve roots would be useful (3). Another question remains whether sonography can be a sensitive marker to detect neurodegeneration, especially in clinically preserved regions.…”

Section: Introductionmentioning

confidence: 99%

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Sonographic evaluation of cervical nerve roots in ALS and its clinical subtypes

et al. 2016

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: Morphological assessment of peripheral nerves in amyotrophic lateral sclerosis (ALS) has been available by sonography. Detection of possible axonal atrophy could be important in predicting progression. Research on correlation between sonographic findings and clinical presentation has been sparse. The aim of the study was to assess possible motor axon loss in patients with ALS by sonography and to correlate the imaging features with clinical subtypes. Patients with either definite or probable ALS and control subjects had sonographic evaluation of the cervical nerve roots (C5, C6, and C7). Each diameter and their sums were measured. The ALS patients were classified by their clinical onset and progression (arm-onset, leg-onset, bulbar, and flail-arm variant) and the sonographic features were compared. Overall, the cervical nerve roots were thinner in ALS than in the controls, but the diagnostic sensitivity was low. The patients with arm dysfunctions tended to show thinner nerve roots than those with normal or relatively preserved arm functions. The four ALS subtypes showed similar diameters of the nerve roots. There was no correlation between the disease duration and the diameters of the nerve roots. Sonography of the cervical nerve roots showed axonal atrophy in ALS and potentially reflects subtle arm dysfunctions.

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“…The recent advent of sonography of a peripheral nerve has shed light on the pathophysiology of peripheral nerve diseases and ALS (Cartwright and Walker, 2013;Cartwright et al, 2011;Nodera et al, 2014). Furthermore, compressive neuropathy such as CTS is sensitively diagnosed by sonography (Cartwright and Walker, 2013;Tai et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Focal nerve enlargement is not the cause for increased distal motor latency in ALS: Sonographic evaluation

Mori¹,

Nodera²,

Takamatsu³

et al. 2015

Clinical Neurophysiology

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Thinning of cervical nerve roots and peripheral nerves in ALS as measured by sonography

Cited by 70 publications

References 18 publications

Ultrasound in the diagnosis of peripheral neuropathy: structure meets function in the neuromuscular clinic

Ultrasound in the diagnosis of peripheral neuropathy: structure meets function in the neuromuscular clinic

Sonographic evaluation of cervical nerve roots in ALS and its clinical subtypes

Focal nerve enlargement is not the cause for increased distal motor latency in ALS: Sonographic evaluation

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