Thinner Regions of Intracranial Aneurysm Wall Correlate with Regions of Higher Wall Shear Stress: A 7T MRI Study

Blankena, R.; Kleinloog, Rachel; Verweij, Bon H.; Ooij, Pim van; Haken, Bennie ten; Luijten, Peter R.; Rinkel, Gabriël J.E.; Zwanenburg, Jaco J.M.

doi:10.3174/ajnr.a4734

Cited by 38 publications

(26 citation statements)

References 19 publications

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“…Improved vessel detection may help reduce vascular complications, and it may improve management of non-tumor pathologies, such as cerebral aneurysms. 4,42 …”

Section: Discussionmentioning

confidence: 99%

First Application of 7-T Magnetic Resonance Imaging in Endoscopic Endonasal Surgery of Skull Base Tumors

et al. 2017

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Background Successful endoscopic endonasal surgery for the resection of skull base tumors is reliant on preoperative imaging to delineate pathology from the surrounding anatomy. The increased signal-to-noise ratio afforded by 7T MRI can be used to increase spatial and contrast resolution, which may lend itself to improved imaging of skull base. In this study, we apply a 7T imaging protocol to patients with skull base tumors and compare the images to clinical standard of care. Methods Images were acquired at 7T on 11 patients with skull base lesions. Two neuroradiologists evaluated clinical 1.5T, 3T, and 7T scans for detection of intracavernous cranial nerves and ICA branches. Detection rates were compared. Images were utilized for surgical planning and uploaded to a neuronavigation platform and used to guide surgery. Results Image analysis yielded improved detection rates of cranial nerves and ICA branches at 7T. 7T images were successfully incorporated into preoperative planning and intraoperative neuronavigation. Conclusion Our study represents the first application of 7T MRI to the full neurosurgical workflow for endoscopic endonasal surgery. We detected higher rates of cranial nerves and ICA branches at 7T MRI compared to 3T and 1.5 T, and found that integration of 7T into surgical planning and guidance was feasible. These results suggest a potential for 7T MRI to reduce surgical complications. Future studies comparing standardized 7T, 3T, and 1.5 T MRI protocols in a larger number of patients are warranted to determine the relative benefit of 7T MRI for endonasal endoscopic surgical efficacy.

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“…Improved vessel detection may help reduce vascular complications, and it may improve management of non-tumor pathologies, such as cerebral aneurysms. 4,42 …”

Section: Discussionmentioning

confidence: 99%

First Application of 7-T Magnetic Resonance Imaging in Endoscopic Endonasal Surgery of Skull Base Tumors

et al. 2017

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“…The study showed a significant inverse association between apparent wall thickness and wall shear stress (mean correlation coefficient −0.35, p<0.05), suggesting that 7T MPIR-TSE could be used to assess spatial wall thickness variations in relation to pathophysiologic processes such as aneurysm growth and rupture. 49 These previous studies, and our experience with 7T imaging (unpublished material), demonstrate that the high spatial resolution achieved with 7T allows detailed characterization of the aneurysm wall and better sampling of signal intensity for determination of wall enhancement. Wadghiri et al tested MPO activity of the vessel wall of clipped aneurysms with 7T ultra HR-VWI MRI.…”

Section: -Tesla Mri Of Brain Aneurysmsmentioning

confidence: 68%

Vessel wall imaging in intracranial aneurysms

Samaniego

Roa

Hasan

2019

J NeuroIntervent Surg

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High-resolution vessel wall imaging (HR-vwi) is becoming a useful tool in the characterization and identification of unstable unruptured brain aneurysms. However, it has not been validated for clinical use. The current evidence on HR-vwi techniques for characterization of brain aneurysms is described in this review. Specific imaging approaches such as aneurysm wall contrast enhancement, MRi-quantitative susceptibility mapping, and 7T MRi are described in detail.

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“…20 These authors suggested that the hemodynamic changes induced by stents promote thrombus formation inside the aneurysm and reduce the risk of aneurysm growth and rupture. Blankena et al 21 studied the correlation between wall shear stress and wall thickness of aneurysms with 7T MR imaging. This group found an inverse correlation between wall shear stress and aneurysm wall thickness.…”

Section: Discussionmentioning

confidence: 99%

Flow Diversion with Low-Profile Braided Stents for the Treatment of Very Small or Uncoilable Intracranial Aneurysms at or Distal to the Circle of Willis

Aydın

Barburoğlu

Sencer

et al. 2017

AJNR Am J Neuroradiol

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Thinner Regions of Intracranial Aneurysm Wall Correlate with Regions of Higher Wall Shear Stress: A 7T MRI Study

Cited by 38 publications

References 19 publications

First Application of 7-T Magnetic Resonance Imaging in Endoscopic Endonasal Surgery of Skull Base Tumors

First Application of 7-T Magnetic Resonance Imaging in Endoscopic Endonasal Surgery of Skull Base Tumors

Vessel wall imaging in intracranial aneurysms

Flow Diversion with Low-Profile Braided Stents for the Treatment of Very Small or Uncoilable Intracranial Aneurysms at or Distal to the Circle of Willis

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