'Think like a bacterium': a helpful concept to prolong the antibiotic era?

Hamilton‐Miller, J. M. T.

doi:10.1111/j.1469-0691.1998.tb00664.x

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Resistance Today1

The Urinary Tract Infection Model1

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2004

2023

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Cited by 4 publications

(2 citation statements)

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“…We have investigated the problem from the points of view of the doctor, the patient, the public and the antibiotic, but have almost entirely neglected the aspect of the other main player, the bacterium. It is my intention here to enlarge upon a previous theme [4], and to try to view antibiotic use and its effects from the viewpoint of a bacterium.…”

Section: Resistance Todaymentioning

confidence: 99%

Antibiotic resistance from two perspectives: man and microbe

Hamilton‐Miller

2004

International Journal of Antimicrobial Agents

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Section: Resistance Todaymentioning

confidence: 99%

Antibiotic resistance from two perspectives: man and microbe

Hamilton‐Miller

2004

International Journal of Antimicrobial Agents

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“…Other Gramnegative bacteria, including Klebsiella spp., Enterobacter spp., Serratia spp., Proteus mirabilis, Ps. aeruginosa and Enterococcus spp., are sometimes involved in UTIs [27,29,30]. E. coli is also the primary agent responsible for CAUTIs, with Ps.…”

Section: The Urinary Tract Infection Modelmentioning

confidence: 99%

Resistance is futile: the bacteriocin model for addressing the antibiotic resistance challenge

Riley

Robinson

Roy

et al. 2012

Biochemical Society Transactions

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Pathogenic bacteria resistant to many or all antibiotics already exist. With the decline in microbiological research at pharmaceutical companies, the high rate at which resistance has evolved and spread has demanded a novel approach to addressing this critical human health issue. In the present paper, we propose a new paradigm in antibiotic discovery and development, one that applies ecological and evolutionary theory to design antimicrobial drugs that are more difficult and/or more costly to resist. In essence, we propose to simply adopt the strategies invented and applied by bacteria for hundreds of millions of years. Our research focuses on bacteriocins, powerful biological weapons, and their use as alternative therapeutics in human health.

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