Thin films of xyloglucans for BSA adsorption

Jó, Tatiane A.; Petri, Denise Freitas Siqueira; Valenga, Francine; Lucyszyn, Neoli; Sierakowski, Maria Rita

doi:10.1016/j.msec.2008.10.035

Cited by 12 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At pH 4.8, the release is hindered because BSA solubility is reduced and BSA positively charged patches can bind to xanthan carboxylate groups. Similar behavior was observed for oxidized galactomannans, carboxymethylcellulose, oxidized xyloglucans . The complex between xanthan and casein, a protein with pI at 4.6, acts as emulsifier for oil in water emulsions …”

Section: Xanthan Gum Networksupporting

confidence: 61%

Xanthan gum: A versatile biopolymer for biomedical and technological applications

Petri

2015

J of Applied Polymer Sci

316

189

View full text Add to dashboard Cite

Xanthan gum is an extracellular polymer produced mainly by the bacterium Xanthomonas campestris. Traditionally it plays an important role in industrial applications as thickener, emulsion stabilizer and it has been added to water-based drilling fluids due to its pseudoplastic behavior and thermal stability. The structural properties of xanthan in solution can be tuned by the temperature and ionic strength; under high ionic strength or low temperature, xanthan chains are arranged in helical conformation, whereas under low ionic strength or high temperature, xanthan chains are coiled. Xanthan high molecular weight favors the building up of physical and chemical networks, which have been used as carriers for drugs and proteins and as scaffolds for cells. In combination with other polymers xanthan has been applied as excipient in tablets or as supporting hydrogels for drug release applications, particularly due to its acid resistance. The large versatility of xanthan gum opens the possibility for the creation of new architectures and additional applications involving this fascinating polymer. AIMSThe purpose of this review is to report on the applications of xanthan gum in biomedical and technological products over the last ten years, but revisiting the background and the highlights of traditional applications as thickener. The in vivo biodegradability and biocompatibility of xanthan gum are fundamental characteristics that allow its use in biomedical applications. The ability to form networks and acid resistance make xanthan gum, as pure excipient or in combination with other polymers, very attractive as drug carriers. The recent combinations with inorganic particles open a range of new applications.

show abstract