Thigh muscles are more susceptible to age-related muscle loss when compared to lower leg and pelvic muscles

Fuchs, Cas J.; Kuipers, Remco; Rombouts, Jan A; Brouwers, Kim; Schrauwen‐Hinderling, Vera B.; Wildberger, Joachim E.; Verdijk, Lex B.; Loon, Luc J.C. van

doi:10.1016/j.exger.2023.112159

Cited by 16 publications

(8 citation statements)

References 45 publications

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“…Last, the availability of MRI data allowed for the reconstruction of 3D muscle volumes, better predictor of muscle strength than CSA measurements ( Akagi et al, 2009 ). As highlighted in previous works ( Trappe et al, 2001 ; Fuchs et al, 2023 ), elder participants had smaller muscles than their younger counterparts. With a larger dataset at hand or combining different datasets, population-specific atlases and robust regression models can be generated (e.g., Handsfield et al, 2014 ), which would expedite the process to estimate muscle volumes, thus, to identify and quantify the presence of sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

Towards a comprehensive biomechanical assessment of the elderly combining in vivo data and in silico methods

Davico,

Labanca,

Gennarelli

et al. 2024

Front. Bioeng. Biotechnol.

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The aging process is commonly accompanied by a general or specific loss of muscle mass, force and/or function that inevitably impact on a person’s quality of life. To date, various clinical tests and assessments are routinely performed to evaluate the biomechanical status of an individual, to support and inform the clinical management and decision-making process (e.g., to design a tailored rehabilitation program). However, these assessments (e.g., gait analysis or strength measures on a dynamometer) are typically conducted independently from one another or at different time points, providing clinicians with valuable yet fragmented information. We hereby describe a comprehensive protocol that combines both in vivo measurements (maximal voluntary isometric contraction test, superimposed neuromuscular electrical stimulation, electromyography, gait analysis, magnetic resonance imaging, and clinical measures) and in silico methods (musculoskeletal modeling and simulations) to enable the full characterization of an individual from the biomechanical standpoint. The protocol, which requires approximately 4 h and 30 min to be completed in all its parts, was tested on twenty healthy young participants and five elderlies, as a proof of concept. The implemented data processing and elaboration procedures allowing for the extraction of several biomechanical parameters (including muscle volumes and cross-sectional areas, muscle activation and co-contraction levels) are thoroughly described to enable replication. The main parameters extracted are reported as mean and standard deviation across the two populations, to highlight the potential of the proposed approach and show some preliminary findings (which were in agreement with previous literature).

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Section: Discussionmentioning

confidence: 99%

Towards a comprehensive biomechanical assessment of the elderly combining in vivo data and in silico methods

Davico,

Labanca,

Gennarelli

et al. 2024

Front. Bioeng. Biotechnol.

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“…Knee flexors and extensors are the primary muscle groups selected for strength testing in the lower extremity. The seated position and ease of thigh and trunk stabilization, in addition to the known susceptibility to age-related muscle loss, make this test the first choice for lower extremity strength testing [ 40 ]. At entry into this study, the normalized isometric knee flexor strength (Nm/kg) in men and women, was higher than that reported by Sarabon et al, who found 1.08 versus 0.79 for men and 0.75 versus 0.64 for women [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…The seated position and ease of thigh and trunk stabilization, in addition to the known susceptibility to age-related muscle loss, make this test the first choice for lower extremity strength testing [ 40 ]. At entry into this study, the normalized isometric knee flexor strength (Nm/kg) in men and women, was higher than that reported by Sarabon et al, who found 1.08 versus 0.79 for men and 0.75 versus 0.64 for women [ 40 ]. Our intervention improved knee flexor strength in men from 1.08 ± 0.31 to 1.21 ± 0.28 and 0.75 ± 0.22 to 0.94 ± 0.28 for women.…”

Section: Discussionmentioning

confidence: 99%

Resistance Exercise Program Is Feasible and Effective in Improving Functional Strength in Post-COVID Survivors

Kaczmarczyk,

Matharu,

Bobowik

et al. 2024

JCM

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Background: Evidence suggests that COVID-19 infection can cause lasting health consequences. Multidisciplinary rehabilitation services have been recommended to reduce the sequalae. However, the effectiveness of physical exercise interventions remains insufficiently documented. The aim of this study was to develop and implement a specific and well-tolerated protocol-based intervention to reduce muscle weakness in older adults impacted by COVID-19. Methods: Forty-six older adults were randomized into intervention and control groups. Isometric and isokinetic strength assessments were conducted for selected muscle groups using a JBA Staniak® torquemeter and Biodex System 3 dynamometer. Functional abilities were evaluated with the Time Up and Go test and Chair Stand Tests. Results: Men in the intervention group demonstrated a significant improvement in static conditions for knee flexors (KFs), trunk extensors (TEs) and trunk flexors (TFs) and in dynamic conditions for knee extensors (KEs). Women in the intervention group showed a significant improvement in static conditions for EFs, KFs, TEs and TFs and in dynamic conditions for a KE and a KF. The interaction GROUP × TESTING SESSION was significant for the Chair Test (s) and Chair Test (n). Conclusions: Our results demonstrate the effectiveness of a well-tolerated, protocol-based approach that can be used to diminish long-lasting functional deficits in post-COVID survivors.

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“…This position was maintained for the entire procedure. As it has previously been reported that anterior thigh and abdominal muscles are the first muscles affected by aging, the rectus femoris (RF), gracilis (GR), and the rectus abdominis (RA) muscles were scanned [ 29 , 30 ]. For the RF and GR muscles, a horizontal line was drawn at 50% between the greater trochanter of the femur and the lateral knee joint line of the right thigh [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Skeletal Muscle Echo Intensity Values Differ Significantly across Ultrasound Parameter Settings

Scafoglieri,

Van den Broeck,

Bartocci

et al. 2024

Life

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Echo intensity determined by muscle ultrasound has been proposed as an efficient method for the assessment of muscle quality. The influence of changing ultrasound parameter settings on echo intensity values was assessed using a standardized approach. In this repeated measures cross-sectional study, sixteen repeated scans of rectus femoris, gracilis, and rectus abdominis were taken in 21 middle-aged persons with a portable Mindray M7 premium ultrasound machine equipped with a linear 5.0–10.0 MHz transducer. The settings of three parameters were fixed: gain, depth, and frequency. The settings of the following adjustable parameters were changed over their entire range: dynamic range, gray map, line density, persistence, and IClear. Repeated measures analyses were performed to evaluate the effect of changing the settings on echo intensity values. In all three muscles, dynamic range, gray map, and IClear correlated significantly (rrm-values ranging between −0.86 and 0.45) with echo intensity. In all three muscles, the echo intensity values differed significantly across the dynamic range (p < 0.013), gray map (p < 0.003), and IClear (p < 0.003). In middle-aged subjects, echo intensity values of lower limb and trunk muscles are significantly related to ultrasound parameters and significantly differ across their respective setting range. For the assessment of muscle quality through ultrasound, it is suggested to fix parameter settings within their midrange in order to minimize the effect of setting-dependent factors on EI values.

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Thigh muscles are more susceptible to age-related muscle loss when compared to lower leg and pelvic muscles

Cited by 16 publications

References 45 publications

Towards a comprehensive biomechanical assessment of the elderly combining in vivo data and in silico methods

Towards a comprehensive biomechanical assessment of the elderly combining in vivo data and in silico methods

Resistance Exercise Program Is Feasible and Effective in Improving Functional Strength in Post-COVID Survivors

Skeletal Muscle Echo Intensity Values Differ Significantly across Ultrasound Parameter Settings

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