“…PPB rates ranged from .6% 11 to 26.9%, 12 and the pooled PPB rate was 5.1% (95% CI, 4.5%-5.7%), with significant heterogeneity across studies (I 2 Z 84.46, P < .001). However, PPB rates were not significantly different according to study design (5.9% in RCTs, 6.1% in prospective studies, and 4.9% in retrospective studies; I 2 > 80%).…”