Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode

Purpose: To study peripapillary choroidal thickness (PPCT) around the optic disc and establish zones using a new swept source optical coherence tomography (SS-OCT) device. To evaluate PPCT differences between patients with multiple sclerosis (MS) and age-and sex-matched healthy controls. Methods: A total of 102 healthy subjects and 51 patients with MS were consecutively recruited. Healthy subjects were divided into teaching (n = 51, used to establish choroidal zones) and validating (n = 51, used to compare measurements with MS patients) populations. An optic disc 6.0 3 6.0-mm three-dimensional scan was obtained using SS-OCT Triton. A 26 3 26 cube-grid centred on the optic disc was generated automatically to measure PPCT. Four choroidal zones were established and used to compare PPCT between healthy controls and patients with MS. Results: Peripapillary choroidal thickness (PPCT) was significantly thinner in patients in all concentric zones (p ≤ 0.0001): 134.02 AE 16.59 lm in MS group versus 171.56 AE 12.43 lm in the control group in zone 2; 182.23 AE 20.52 versus 219.03 AE 17.99 lm, respectively, in zone 3; and 223.52 AE 10.70 versus 259.99 AE 10.29 lm, respectively, in zone 4. The choroidal thinning in the MS group tended to decrease as we distanced from the optic nerve head. Peripapillary choroidal thickness (PPCT) had a similar pattern in controls and MS; it was thicker in the superior region, followed by temporal, nasal and inferior regions. Conclusion: Patients with MS showed peripapillary choroidal thinning when compared with healthy subjects in all zones around the optic disc. Peripapillary choroidal tissue shows a concentric pattern, increasing in thickness when increasing the distance from the optic nerve. The new SS-OCT could be useful for evaluating choroidal thinning in clinical practice.

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“…These tools allow us to visualize the actual morphology of the choroidal layer and the possible effects of different diseases (Peng et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…Peng et al. () used SD‐OCT automated segmentation to distinguish between eyes of patients with one episode of optic neuritis and patients with neuromyelitis, but they did not measure choroid.…”

Section: Discussionmentioning

confidence: 99%

Changes in peripapillary choroidal thickness in patients with multiple sclerosis

García‐Martín

Jarauta

Júlvez

et al. 2018

Acta Ophthalmologica

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“…Because RNFL thinning is a characteristic of glaucoma, subjects with glaucoma were excluded. Participants were also excluded if they had a history of optic neuritis, intraocular surgery apart from cataract extraction, or a history of visual loss apart from refractive error as these conditions may affect the RNFL thickness [65–67]. In addition, individuals were excluded if the epiretinal membrane was observed using OCT imaging [68].…”

Section: Methodsmentioning

confidence: 99%

Change in retinal structural anatomy during the preclinical stage of Alzheimer's disease

Santos

Johnson

Sinoff

et al. 2018

Alz & Dem Diag Ass & Dis Mo

103

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Introduction We conducted a 27-month longitudinal study of mid-life adults with preclinical Alzheimer's disease (AD), using spectral domain optical coherence tomography to compare changes in volume and thickness in all retinal neuronal layers to those of age-matched healthy control subjects. Methods Fifty-six older adults (mean age = 65.36 years) with multiple risk factors for AD completed spectral domain optical coherence tomography retinal imaging and cognitive testing at baseline. Twenty-seven months later, they completed the same examinations and an 18 F-florbetapir positron emission tomography imaging study. Results Compared to healthy control subjects, those in the preclinical stage of AD showed a significant decrease in macular retinal nerve fiber layer (mRNFL) volume, over a 27-month follow-up interval period, as well as a decrease in outer nuclear layer and inner plexiform layer volumes and thickness in the inferior quadrant. However, only the mRNFL volume was linearly related to neocortical positron emission tomography amyloid standardized uptake value ratio after controlling for any main effects of age ( R 2 = 0.103; ρ = 0.017). Furthermore, the magnitude of mRNFL volume reduction was significantly correlated with performance on a task of participants' abilities to efficiently integrate visual and auditory speech information (McGurk effect). Discussion We observed a decrease in mRNFL, outer nuclear layer, and inner plexiform layer volumes, in preclinical AD relative to controls. Moreover, the largely myelinated axonal loss in the RNFL is related to increased neocortical amyloid-β accumulation after controlling for age. Volume loss in the RNFL, during the preclinical stage, is not related to performance on measures of episodic memory or problem solving. However, this retinal change does appear to be modestly related to relative decrements in performance on a measure of audiovisual integration efficiency that has been recently advanced as a possible early cognitive marker of mild cognitive impairment.

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“…For the ION eyes, the sub‐MCT decreased only in the ≥6‐month cohort after ON attacks, which was consistent with previous studies only choroidal thickness exhibiting thinning during the chronic stage of ON (Wang et al 2014). The different patterns could imply that the pathogenesis of AQP4‐IgG+/NMOSD eyes with a history of ON is distinct from that of the AQP4‐IgG sero‐negative ON, as seen in our previous studies (Peng et al 2016; Peng et al 2017).…”

Section: Discussionmentioning

confidence: 53%

“…Based on these results and the international diagnostic criteria for NMOSD that core clinical characteristic ON, plus sero‐positive AQP4‐IgG was classified as NMOSD with AQP4‐IgG (Wingerchuk et al 2015), all the ON patients were divided two cohorts: ON with a serum AQP4‐IgG‐positive patients were grouped in AQP4‐IgG sero‐positive NMOSD (AQP4‐IgG+/NMOSD) cohort, and AQP4‐IgG sero‐negative ON patients excluding MS were grouped in ION cohort. As the retina and optic nerve undergo changes in different stages of ON (Gabilondo et al 2015; Peng et al 2016), the ON patients were further divided into four sub‐cohorts according to long term after the initial ON attacks: 0–2, 2–4, 4–6 months and more than 6 months (≥6 months). For the unilateral AQP4‐IgG+/NMOSD patients, we also estimated the retinal microstructure and sub‐MCT alterations in the AQP4‐IgG+/NMOSD eyes with a history of ON (AQP4‐IgG+/NMOSD‐ON), following the healthy eyes (AQP4‐IgG+/NMOSD‐NON) as internal controls.…”

Section: Methodsmentioning

confidence: 99%

Different alteration patterns of sub‐macular choroidal thicknesses in aquaporin‐4 immunoglobulin G antibodies sero‐positive neuromyelitis optica spectrum diseases and isolated optic neuritis

Peng

Yang

et al. 2020

Acta Ophthalmologica

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Purpose The ocular choroid is a sensitive biomarker of vascular perfusion in optic neuritis (ON) patients due to its vascular structures. The purpose of this study was to evaluate alterations in sub‐macular choroidal thicknesses (sub‐MCT) in aquaporin‐4 immunoglobulin G antibodies (AQP4‐IgG) sero‐positive neuromyelitis optica spectrum disease (AQP4‐IgG+/NMOSD) and isolated ON (ION) patients using optical coherence tomography (OCT). Methods A total of 208 ON patients (275 eyes) and healthy controls (HCs) who underwent sub‐MCT and retinal microstructure detection with OCT were enrolled in this study. Results Among all the ON patients, 102 (49.0%) cases were identified as serum AQP4‐IgG‐positive, with 106 (51.0%) cases being negative, excluding multiple sclerosis as the ION cohort. The sub‐MCT in the AQP4‐IgG+/NMOSD patients decreased in 0–6 months after ON attacks. However, for the ION cohort, the sub‐MCT decreased in 0–2 months and then stayed normal or slightly increased in 2–4 months after the first ON attack, finally sharply decreasing after 6 months. For unilateral AQP4‐IgG+/NMOSD patients, eyes without ON also presented retinal layer thinning and sub‐MCT slight reduction independent of ON attacks. Conclusions The sub‐MCT in AQP4‐IgG+/NMOSD patients were reduced at all stages of ON, which distinguished the ION patients as decreasing only at chronic stage of ON. It implied that ocular vascular hypoperfusion plays a potential role in ON pathogenesis and the different patterns could be caused by the distinct pathogenesis of AQP4‐IgG+/NMOSD and ION.

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Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode

Abstract: Neuromyelitis spectrum optic neuritis (NMOSD-ON) patients had more pRNFL and mRNFL loss compared to ION patients after one episode. Spectral domain optical coherence tomography (SD-OCT) may help to distinguish NMOSD-ON from ION with only moderate diagnostic accuracy.

Cited by 15 publications

References 39 publications

Changes in peripapillary choroidal thickness in patients with multiple sclerosis

Changes in peripapillary choroidal thickness in patients with multiple sclerosis

Change in retinal structural anatomy during the preclinical stage of Alzheimer's disease

Different alteration patterns of sub‐macular choroidal thicknesses in aquaporin‐4 immunoglobulin G antibodies sero‐positive neuromyelitis optica spectrum diseases and isolated optic neuritis

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