Thickness of epicardial and pericoronary adipose tissue measured using 128-slice MSCT as predictors for risk of significant coronary artery diseases

Abstract

Aim Determination the relationship between the epicardial adipose tissue thickness (EATT) and pericoronary adipose tissue thickness (PATT) and the risk of significant coronary artery diseases (CAD) using the coronary artery calcium score (CACS). Materials and methods The study group consisted of 80 patients. The risk of significant CAD was estimated based on CACS. Adipose tissue thickness was measured based on multiplanar reformation (MPR), left ventricle short axis and mid-chamber level. EATT in the middle of the length of the right ventricular free wall, PATT around the left anterior descending (LAD), around the left circumflex (LCX) and around the right coronary artery in the posterior interventricular sulcus (RCA). Results The median (IQR) values of CACS and EATT were 12.00 (97.90) and 8.65 (3.90) mm. It was found that in the subgroup CACS = 0 statistically significantly lower than in the subgroup CACS > 0 were mean values EATT and PATT RCA. Based on the regression analysis, it was demonstrated that higher CACS is associated with higher EATT, independent of older age and higher BMI. On the basis the ROC curve analysis, the highest prediction sensitivity of 98.4% was demonstrated for EATT ≥ 16.7 mm as a predictor of high risk of significant CAD and the highest specificity of 61.5% for the criterion EATT ≤ 8.7 mm as a predictor of practically no risk of significant CAD. Conclusion There is a positive relationship between the risk of a significant CAD estimated based on the coronary artery calcium score and the epicardial adipose tissue thickness.

The relation between pericoronary fat thickness and density quantified by coronary computed tomography angiography with coronary artery disease severity

“…Demircelik et al 7 also found that the calcium score was higher in the obstructive group. In accordance with Gać et al 26 and Rosito et al, 27 we found a significant association between the calcium score and CT-measured EAT and PCFT.…”

Evaluation of epicardial adipose tissue by coronary multi-detector computed tomography: an independent predictor of obstructive coronary artery disease

“…Some reports are in line with our results, Xie et al [12] described that EAT thickness was higher in CAD and significantly increased during progression of CAD severity. In a study conducted by Gać et al [13], it was indicated that positive correlation was noted between significant CAD, EAT thickness and PCFT in 80 suspected patients by coronary CT angiography. Other studies had similar results as our data regarding correlation of EAT thickness and PCFT and obstructive CAD [14,15].…”

Association of Epicardial and Pericardial Adipose Tissue Volumes with Coronary Artery Calcification

“…CCTA is a cross-sectional method that enables examination of the vascular lumen, vessel wall, and surrounding tissue in addition to the lumen. 15) CCS is considered a good marker of coronary atherosclerosis. 16) CCS provides an overall evaluation of atherosclerosis by measuring the degree of coronary calcification present in atherosclerotic plaques and reflecting the lifetime cumulative influence of risk factors as well as inherited and environmental markers.…”