Thickness as Prognostic Aid in Upper Aerodigestive Tract Cancer

Moore, Condict

doi:10.1001/archsurg.1986.01400120060009

Cited by 155 publications

(109 citation statements)

References 14 publications

(1 reference statement)

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“…18 Moore et al found that survival correlated better with TT when measured from a theoretical construction of a basement membrane through the tumor than from the surface of the tumor. 19,20 In a study originating from Tata Memorial Hospital, Mumbai, Kane et al compared depths measured from the surface of a tumor versus from adjacent normal mucosa and concluded that the latter (referred to as microscopic depth) had a stronger correlation with the risk of lymphnode involvement. 20 This was the method adopted in our study for estimation of tumor thickness.…”

Section: Discussionmentioning

confidence: 99%

Risk factors in oral carcinoma and the relationship between tumor thickness and regional nodal involvement: a pilot study in a semi urban population in New Delhi, India

2017

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Background: Oral squamous cell carcinoma (OSCC) is a major public health problem worldwide, with approximately 275,000 cases annually and a strong association with risk factors like smoking. It is a subtype of head & neck cancer involving the oral cavity. The present study evaluated the role of various risk factors in the development of oral carcinoma among our patient population.Methods: A total of 40 cases of oral carcinoma with radical neck dissection were evaluated. Data on the age, personal history and presenting clinical features were analyzed. The depth of the tumor and the maximum tumor thickness were carefully evaluated. Also, pathological T-stage, the presence/absence of vascular and peri-neural infiltration was evaluated in each case. The presence of nodal metastases and the stage of the tumor was assessed. Data was tabulated and correlation of nodal metastasis with tumor thickness, pathological T-stage, vascular invasion, and peri-neural infiltration was evaluated by appropriate statistical analysis method.Results: A total of 40 cases, 82.5% males and 17.5% females, were all smokers with history of consumption of smoking or smokeless or both. Tongue was the most common site of oral carcinoma (37.5%) involvement, histological characterization of all were Squamous cell carcinoma with majority of the patients in pathological stage II. A significant association between the tumor thickness and metastasis was also seen. Conclusions: The tumor thickness of oral squamous cell carcinoma was found to be an important prognostic indicator for the occurrence of metastases to the regional cervical lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Risk factors in oral carcinoma and the relationship between tumor thickness and regional nodal involvement: a pilot study in a semi urban population in New Delhi, India

2017

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“…Moore et al (1986b) noted that tumour thickness was an accurate predictor of lymph node metastasis; however, its usefulness might be limited because measurement requires resection of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Expression of E-cadherin, α-catenin, and β-catenin in the process of lymph node metastasis in oral squamous cell carcinoma

et al. 2003

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Regional lymph node metastasis is a very important prognostic indicator. In the metastatic process, reduction in cell to cell adhesion including E-cadherin -catenin cell adhesion complex is an essential step. We investigated immunohistochemical expression of Ecadherin, a-catenin and b-catenin in 159 tissue samples from patients with oral squamous cell carcinoma and examined the correlation between their expressions and the presence of regional lymph node metastasis. Significantly greater reduction in expression levels of E-cadherin, a-catenin and b-catenin was found in the metastatic group (n ¼ 64) compared to the nonmetastatic group (n ¼ 95) (P ¼ 0.007, 0.001, 0.001, respectively). However, there was no significant correlation between their expressions and the features of the regional metastasis, the number of metastatic lymph nodes or the presence of extracapsular metastasis. These data suggest that evaluation of the immunohistochemical expression of E-cadherin, a-catenin and b-catenin is extremely valuable for the diagnosis of metastatic occurrence.

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“…Currently, many studies have demonstrated a good correlation between depth of tumor invasion and the presence of occult lymph node metastasis, prompting many institutions to adopt depth of invasion as an indicator for necessity of lymph node dissection. However, these aforementioned studies have used several different cut-off points for depth of invasion, ranging from 1.5 to 10 mm [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The studies also report differing methods of measurement, thus further complicating the issue.…”

Section: Introductionmentioning

confidence: 99%

Muscle Invasion in Oral Tongue Squamous Cell Carcinoma as a Predictor of Nodal Status and Local Recurrence: Just as Effective as Depth of Invasion?

Chandler

Vance

Budnick

et al. 2011

Head and Neck Pathol

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Tumor depth of invasion (DOI) is a histologic feature that consistently correlates with lymph node metastasis; however, there are many difficulties with accurately assessing DOI. The aim of this study was to identify a simpler and more reproducible method of determining DOI, by using skeletal muscle invasion as a surrogate marker of depth. Oral tongue squamous cell carcinoma American Joint Committee on Cancer (AJCC) stage T1 cases were identified in the Emory University Department of Pathology database. 61 cases, with a minimum of 2 years of follow-up, were included in the study. Cases were examined histologically to assess muscle invasion and DOI. The two methods of measurement were analyzed to determine the positive predictive value (PPV) of DOI or muscle invasion for both nodal disease and local recurrence. Cases with muscle invasion had a 23.3% PPV of occult lymph node metastasis. Cases with DOI of greater than 3 mm had a 29.7% PPV of occult lymph node metastasis. Cases with muscle invasion had a 43.7% PPV of local tumor recurrence. Cases with maximum DOI of greater than 3 mm had a 40.4% PPV of tumor recurrence. Although the PPV of muscle invasion in regards to nodal status was slightly less than DOI, it represents a more easily reproducible parameter which could guide surgeons in determining if the case warrants an elective neck dissection in a cN0 (clinically negative) neck. Interestingly, the PPV of local recurrence was higher with muscle invasion than DOI, and may represent an important indicator for extent of resection.

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Thickness as Prognostic Aid in Upper Aerodigestive Tract Cancer

Cited by 155 publications

References 14 publications

Risk factors in oral carcinoma and the relationship between tumor thickness and regional nodal involvement: a pilot study in a semi urban population in New Delhi, India

Risk factors in oral carcinoma and the relationship between tumor thickness and regional nodal involvement: a pilot study in a semi urban population in New Delhi, India

Expression of E-cadherin, α-catenin, and β-catenin in the process of lymph node metastasis in oral squamous cell carcinoma

Muscle Invasion in Oral Tongue Squamous Cell Carcinoma as a Predictor of Nodal Status and Local Recurrence: Just as Effective as Depth of Invasion?

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