Thickness and Diameter in Melanoma: Is There a Relation?

Crocetti, Emanuele; Fancelli, Laura; Caldarella, Adele; Buzzoni, Carlotta

doi:10.5301/tj.5000369

Cited by 17 publications

(17 citation statements)

References 8 publications

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“…The absence of any significant correlation between Breslow thickness and melanoma diameter in the current study contrasts with findings in a study in Tuscany of 2071 melanomas, which found a statistically significant, but small correlation ( r = 0.39) 23 . However, they also found that a non‐negligible proportion of small melanomas was thick and/or nodular, this being consistent with 34.5% of primary melanomas < 6 mm in diameter in the current study being invasive (Table ).…”

Section: Discussioncontrasting

confidence: 99%

Characteristics of 637 melanomas documented by 27 general practitioners on the Skin Cancer Audit Research Database

et al. 2021

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Background and Objective: Most melanomas (including melanomas in situ), in Australasia, are treated by general practitioners (GPs). Previously undescribed, the characteristics of a series of melanomas treated by multiple GPs are examined.Patients and Methods: Six hundred and thirtyseven melanomas treated by 27 Australasian GPs during 2013 and documented on the Skin Cancer Audit Research Database (SCARD) were analysed by anatomical site, subtype, Breslow thickness, diameter, associated naevi and linked adverse outcomes.Results: Most melanomas (59.7%) were on males, mean age at diagnosis being 62.7 years (range 18-96). Most (65.0%) were in situ, with a high incidence of lentiginous melanoma (LM) (38.8%) and 32% were naevus associated. Most LM (86.4%) were in situ, compared to 55% of superficial spreading melanoma (SSM) (P < 0.0001). There was male predominance on the head, neck and trunk and female predominance on extremities. There was no significant association between Breslow thickness and diameter, with small melanomas as likely to be thick as large melanomas, and melanomas ≤3 mm diameter, on average, more likely to be invasive than larger melanomas. There was a positive correlation between age and both melanoma diameter and Breslow thickness. Seven cases progressed to melanomaspecific death: Five nodular melanoma (NM) and two SSM, one of which was thin (Breslow thickness 0.5 mm).Conclusions: A large series of melanomas treated by Australasian GPs were predominantly in situ, with a high proportion of LM subtype. With implications for GP training, NM linked to death was overrepresented and there was a novel finding that older patients had larger diameter melanomas.

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Section: Discussioncontrasting

confidence: 99%

Characteristics of 637 melanomas documented by 27 general practitioners on the Skin Cancer Audit Research Database

et al. 2021

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“…Although previous studies have generally shown positive correlation between Breslow thickness and diameter, 19 small size does not exclude invasion 20–24 . In the present study, two dermoscopic features, i.e., blue‐white veil and negative pigment network, were associated with invasion in melanomas measuring ≤5 mm.…”

Section: Discussioncontrasting

confidence: 75%

Dermoscopic predictors of melanoma in small diameter melanocytic lesions (mini‐melanoma): a retrospective multicentric study of 269 cases

et al. 2023

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Background Incidence of cutaneous melanoma is steadily growing, and its early recognition is of paramount importance. Small, pigmented lesions often represent a challenge for the clinician, as predictors of melanoma have not yet been uniquely identified in this setting. Objectives To identify dermoscopic features that aid in distinguishing small diameter melanomas (≤5 mm) from equivocal melanocytic nevi measuring ≤5 mm. Methods A retrospective multicenter study was conducted to collect demographics, clinical and dermoscopic pictures of (i) histology‐proven flat melanomas, measuring ≤5 mm, (ii) histology‐proven but clinically/dermoscopically equivocal melanocytic nevi measuring ≤5 mm, and (iii) histology‐proven flat melanomas, measuring >5 mm. An independent dermoscopic evaluation was performed. Differences in predefined dermoscopic features were assessed across the three groups. Results A total of 103 melanomas measuring ≤5 mm were collected; 166 control lesions, comprising 85 large (>5 mm) melanomas and 81 dubious, clinically equivocal melanocytic nevi measuring ≤5 mm were included. Of the 103 mini‐melanomas, only 44 were melanoma in situ. Five dermoscopic predictors of melanoma were identified for the assessment of flat, non‐facial melanocytic lesions measuring ≤5 mm, namely: atypical pigment network, blue‐white veil, pseudopods, peripheral radial streaks, and presence of more than one color. The latter were combined into a predictive model capable of identifying melanoma with 65% sensitivity and 86.4% specificity, at a cut‐off score of 3. Among melanomas measuring ≤5 mm, presence of a blue‐white veil (P = 0.0027) or negative pigment network (P = 0.0063) was associated with invasiveness. Conclusion A set of five dermoscopic predictors of melanoma, atypical pigment network, blue‐white veil, pseudopods, peripheral radial streaks, and presence of more than one color is proposed for the assessment of flat, non‐facial melanocytic lesions measuring ≤5 mm.

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“…It can therefore be considered that their diagnosis was delayed. 3 , 4 , 5 Patients may also have experienced diagnostic delays because they were afraid of becoming infected with SARS-CoV-2, underestimated the seriousness of their skin lesion, or did not seek care for small, asymptomatic, or hidden lesions. 6 …”

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confidence: 99%

[Translated article] How Has the COVID-19 Pandemic and Lockdown Affected Breslow Thickness in Cutaneous Melanoma?

Aldecoa-Otalora

Pascual

Iturriagagoitia

et al. 2022

Actas Dermo-Sifiliográficas

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Thickness and Diameter in Melanoma: Is There a Relation?

Abstract: There was a statistically significant, but small, correlation between Breslow's thickness and diameter in skin melanomas. Moreover, a non-negligible proportion of small lesions were thick and/or nodular.

Cited by 17 publications

References 8 publications

Characteristics of 637 melanomas documented by 27 general practitioners on the Skin Cancer Audit Research Database

Characteristics of 637 melanomas documented by 27 general practitioners on the Skin Cancer Audit Research Database

Dermoscopic predictors of melanoma in small diameter melanocytic lesions (mini‐melanoma): a retrospective multicentric study of 269 cases

[Translated article] How Has the COVID-19 Pandemic and Lockdown Affected Breslow Thickness in Cutaneous Melanoma?

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