Thickness and an Altered miRNA Expression in the Epicardial Adipose Tissue Is Associated With Coronary Heart Disease in Sudden Death Victims

Marí-Alexandre, Josep; Barceló-Molina, Moisés; Sanz‐Sánchez, Jorge; Molina, Pilar; Sancho, Jennifer; Abellán, Yolanda; Santaolaria-Ayora, María Luisa; Giner, Juan Manuel Llopis; Martínez‐Dolz, Luis; Estellés, Amparo; Braza-Boïls, Aitana; Zorio, Esther

doi:10.1016/j.rec.2017.12.007

Cited by 14 publications

(16 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent findings have indicated that miRNA is related to the genesis and development of atherosclerosis (8,9). miRNA is extensively involved in the whole process of atherosclerosis (10).…”

Section: Original Articlementioning

confidence: 99%

MiR-339 is a potential biomarker of coronary heart disease to aggravate oxidative stress through Nrf2/FOXO3 targeting Sirt2

Shi¹,

Zhang²,

Zhang³

et al. 2021

Ann Palliat Med

View full text Add to dashboard Cite

Background: MicroRNA (miRNA) is a class of small-molecule RNA that can regulate gene expression at post-transcription level. It is involved in the genesis and development of multiple diseases. The aim of this paper was to explore the mechanisms of miR-339 in coronary heart disease (CHD). Methods: In this study, we enrolled patients with CHD from Beijing Chaoyang Hospital and performed animal experiments on CHD rats. In vitro experiments, such as histopathologic assay, quantitative real-time PCR assay, luciferase reporter assay, western blotting assay, and immunofluorescence assay were carried out to characterize the contents and associations of miR-339, Nrf2, FOXO3, and Sirt2 in CHD samples and cells. In vivo model was also established on rats. Results: In CHD rat, miR-339 was up-regulated compared with control group. The expression of miR-339 up-regulation increased oxidative stress in vitro model via suppression of Sirt2/Nrf2/FOXO3. However, down-regulation of miR-339 expression inhibited oxidative stress in vitro model via activation of Sirt2/Nrf2/ FOXO3. The Sirt2 or Nrf2 inhibitor reduced the protective effect of miR-339 down-regulation on oxidative stress in vitro model. Conclusions: Down-regulation miR-339 may be the new targets to treat CHD through Nrf2/FOXO3targeting Sirt2, and miR-339 may be a potential biomarker of CHD.

show abstract

“…Recent findings have indicated that miRNA is related to the genesis and development of atherosclerosis (8,9). miRNA is extensively involved in the whole process of atherosclerosis (10).…”

Section: Original Articlementioning

confidence: 99%

MiR-339 is a potential biomarker of coronary heart disease to aggravate oxidative stress through Nrf2/FOXO3 targeting Sirt2

Shi¹,

Zhang²,

Zhang³

et al. 2021

Ann Palliat Med

View full text Add to dashboard Cite

show abstract

“…Additional studies demonstrated that miRNA 628-5p expression dysregulation was relevant in lipid metabolism, adipocyte physiopathology, or other related pathways involved in atherosclerosis and plaque destabilization. 47 Finally, miRNA 628-5p was reported to be a potential therapeutic agent against the Middle East respiratory syndrome coronavirus (MERS-CoV) 48 and was found to be overexpressed in samples from subjects with autism spectrum disorder compared to control subjects, indicating its possible functionality as a biomarker for this disease. 49 Conclusions and future directions miRNAs represent a new frontier in cancer prognosis and therapeutics for their high availability and their ability to target and regulate downstream molecular targets.…”

Section: Role Of Mirna 628-5p In Other Physiological Processesmentioning

confidence: 99%

Section: Role Of Mirna 628-5p In Other Physiological Processesmentioning

confidence: 99%

Emerging role of microRNA 628-5p as a novel biomarker for cancer and other diseases

2019

View full text Add to dashboard Cite

MicroRNAs are a family of small, single-stranded RNAs that have key roles in regulating multiple signaling pathways within a cell. Studies have implicated aberrant expression of microRNAs in the development and progression of several pathologies including cancer. MicroRNAs are relatively stable and readily available in body fluids and tissues, making them desirable biomarkers for prognostic and diagnostic purposes in an array of diseases. MicroRNA 628 (5p/3p variants) is located in the 15q21.3 cancer-related region, and evidence suggests its association with various pathologies. The -5p mature variant, microRNA 628-5p, has been reported to be differentially expressed in various cancers, and its expression has been mostly associated with tumor suppression but there are few reports identifying its role in cancer progression. Several studies have also suggested its utility in diagnosis and prognosis of various cancers. Dysregulation of microRNA 628-5p has also been implicated in embryonal implantation defects, autism, immune modulation, myogenesis, cardiovascular disease, viral infection, and skeletal muscle repair. Here, we have provided a comprehensive review on available literature explaining the role of microRNA 628-5p as a potential cancer biomarker as well as briefly describe its function in other diseases and normal physiological conditions. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

show abstract

“…At present, more and more studies have confirmed that serum osteoprotegerin is closely related to patients with CHD, and can be used as a marker to predict cardiovascular disease 5,6 . The latest studies confirmed that EAT is not only closely related to CHD, but also to the incidence of atrial fibrillation, thromboembolism and long‐term recurrence after radiofrequency ablation 7,8 . Some hospitals have carried out research in this direction, but it has not been fully promoted.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 The latest studies confirmed that EAT is not only closely related to CHD, but also to the incidence of atrial fibrillation, thromboembolism and long-term recurrence after radiofrequency ablation. 7,8 Some hospitals have carried out research in this direction, but it has not been fully promoted.…”

mentioning

confidence: 99%

Correlation of osteoprotegerin, sRANKL, inflammatory factors and epicardial adipose tissue volume with coronary heart disease

Dan

Chen

et al. 2021

Int J Clin Pract

View full text Add to dashboard Cite

According to the survey report of the World Health Organization (WHO) in 2015, coronary heart disease has become the leading cause of human death. About 8.76 million patients die of coronary heart disease every year, accounting for 26.6% of the total number of human deaths in the world. With the acceleration of the ageing population, the number of deaths has increased dramatically.Coronary atherosclerosis can cause vascular stenosis or blockage, and cause myocardial necrosis and induce heart disease, which

show abstract

Thickness and an Altered miRNA Expression in the Epicardial Adipose Tissue Is Associated With Coronary Heart Disease in Sudden Death Victims

Cited by 14 publications

References 32 publications

MiR-339 is a potential biomarker of coronary heart disease to aggravate oxidative stress through Nrf2/FOXO3 targeting Sirt2

MiR-339 is a potential biomarker of coronary heart disease to aggravate oxidative stress through Nrf2/FOXO3 targeting Sirt2

Emerging role of microRNA 628-5p as a novel biomarker for cancer and other diseases

Correlation of osteoprotegerin, sRANKL, inflammatory factors and epicardial adipose tissue volume with coronary heart disease

Contact Info

Product

Resources

About