Thicker Posterior Insula Is Associated With Disease Duration in Women With Irritable Bowel Syndrome (IBS) Whereas Thicker Orbitofrontal Cortex Predicts Reduced Pain Inhibition in Both IBS Patients and Controls

Piché, Mathieu; Chen, Jen–I; Roy, Mathieu; Poitras, Pierre; Bouin, Mickaël; Rainville, Pierre

doi:10.1016/j.jpain.2013.05.009

Cited by 59 publications

(45 citation statements)

References 79 publications

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“…This was indicated by the absence of differences between the placebo and control conditions in pain-induced neural activation upon within-group analyses, which resulted in a significant group difference for the midcingulate cortex when compared with healthy controls. Herein, patients with IBS revealed less effective downmodulation of midcingulate cortex activation during painful stimulation in the placebo condition, consistent with a deficit in central pain inhibition 30 31. This fits with our earlier observation that patients with IBS were less able to effectively modulate pain-induced neural activation in a relaxation condition compared with healthy controls 16.…”

Section: Discussionsupporting

confidence: 89%

Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers

Schmid

Langhorst

Gass

et al. 2014

Gut

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Section: Discussionsupporting

confidence: 89%

Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers

Schmid

Langhorst

Gass

et al. 2014

Gut

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“…GM increases have also been observed in IBS patients, with increases observed in the hypothalamus [56], CC and OFC [61], INS [62] and S1/M1 [57, 58]. Both positive correlations [57, 62] and no correlation [57, 58, 62] have been shown between GM increases and symptom severity and chronicity.…”

Section: Gray Matter In Irritable Bowel Syndromementioning

confidence: 99%

“…Both positive correlations [57, 62] and no correlation [57, 58, 62] have been shown between GM increases and symptom severity and chronicity.…”

Section: Gray Matter In Irritable Bowel Syndromementioning

confidence: 99%

Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature

Walitt

Čeko²,

Gracely³

et al. 2016

CRR

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Central sensitivity syndromes are characterized by distressing symptoms, such as pain and fatigue, in the absence of clinically obvious pathology. The scientific underpinnings of these disorders are not currently known. Modern neuroimaging techniques promise new insights into mechanisms mediating these postulated syndromes. We review the results of neuroimaging applied to five central sensitivity syndromes: fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, temporomandibular joint disorder, and vulvodynia syndrome. Neuroimaging studies of basal metabolism, anatomic constitution, molecular constituents, evoked neural activity, and treatment effect are compared across all of these syndromes. Evoked sensory paradigms reveal sensory augmentation to both painful and non-painful stimulation. This is a transformative observation for these syndromes, which were historically considered to be completely of hysterical or feigned in origin. However, whether sensory augmentation represents the cause of these syndromes, a predisposing factor, an endophenotype, or an epiphenomenon cannot be discerned from the current literature. Further, the result from cross-sectional neuroimaging studies of basal activity, anatomy, and molecular constituency are extremely heterogeneous within and between the syndromes. A defining neuroimaging “signature” cannot be discerned for any of the particular syndromes or for an over-arching central sensitization mechanism common to all of the syndromes. Several issues confound initial attempts to meaningfully measure treatment effects in these syndromes. At this time, the existence of “central sensitivity syndromes” is based more soundly on clinical and epidemiological evidence. A coherent picture of a “central sensitization” mechanism that bridges across all of these syndromes does not emerge from the existing scientific evidence.

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“…IBS patients showed association of disease onset with thicker right posterior insula, but the association with psychological symptoms was not proved [20]. The results of another study support the hypothesis that IBS patients with chronic pain exhibit long-term microstructural changes within the brain, particularly in cortical regions associated with integration of sensorial information and corticothalamic modulation [21].…”

Section: Reviewmentioning

confidence: 99%

The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations

et al. 2014

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Irritable bowel syndrome (IBS) is a functional syndrome characterized by chronic abdominal pain accompanied by altered bowel habits. Although generally considered a functional disorder, there is now substantial evidence that IBS is associated with a poor quality of life and significant negative impact on work and social domains. Neuroimaging studies documented changes in the prefrontal cortex, ventro-lateral and posterior parietal cortex and thalami, and implicate alteration of brain circuits involved in attention, emotion and pain modulation. Emerging data reveals the interaction between psychiatric disorders including generalized anxiety disorder, panic disorder, major depressive disorder, bipolar disorder, and schizophrenia and IBS, which suggests that this association should not be ignored when developing strategies for screening and treatment. Psychological, social and genetic factors appear to be important in the development of IBS symptomatology through several mechanisms: alteration of HPA axis modulation, enhanced perception of visceral stimuli or psychological vulnerability. Elucidating the molecular mechanisms of IBS with or without psychiatric comorbidities is crucial for elucidating the pathophysiology and for the identification of new therapeutical targets in IBS.

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Thicker Posterior Insula Is Associated With Disease Duration in Women With Irritable Bowel Syndrome (IBS) Whereas Thicker Orbitofrontal Cortex Predicts Reduced Pain Inhibition in Both IBS Patients and Controls

Cited by 59 publications

References 79 publications

Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers

Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers

Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature

The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations

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