Thickening of the somatosensory cortex in migraine without aura

Kim, Ji Hyun; Kim, Ho Jin; Suh, Sang Il; Seo, Woo Keun; Oh, Kyungmi; Koh, Seong Beom

doi:10.1177/0333102414531155

Cited by 56 publications

(67 citation statements)

References 43 publications

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“…Migraine is a heterogeneous neurological disease. Some datasets only enrolled episodic migraineurs [12,15,16,22,[24][25][26]28], while some other datasets included both episodic and chronic migraineurs [13,14] or only chronic migraineurs [11,44]. Majority of the datasets (n = 14) in the CBMA included patients with mixed gender [10, 11, 13-17, 22, 25-28, 44], while two datasets only included female migraine patients [23,24] and one only male migraine patients [12].…”

Section: Discussionmentioning

confidence: 99%

Cortical thickness in migraine: a coordinate-based meta-analysis

Sheng

Shi³

et al. 2020

Preprint

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Background Cortical thickness (CTh) analysis is a popular method to characterize brain morphometry. Many studies have been performed to investigate CTh abnormalities in migraine. However, the results from these studies were not consistent and even conflicting. These divergent results hinder us from obtaining a clear picture of brain morphometry regarding CTh alterations in migraine. Coordinate-based meta-analysis (CBMA) is a promising technique to quantitatively pool individual neuroimaging studies to identify consistent brain areas involved. Methods Electronic databases (PubMed, Embase, Web of Science, China National Knowledge Infrastructure, WanFang, and SinoMed) and other sources (bioRxiv and reference lists of relevant articles and reviews) were systematically searched for studies that compared regional CTh differences between patients with migraine and healthy controls (HCs) up to May 15, 2020. A CBMA was performed using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) approach. Results In total, we identified 16 studies with 17 datasets reported that were eligible for the CBMA. The 17 datasets included 872 patients with migraine (average sample size 51.3, mean age 39.6 years, 721 females) and 949 HCs (average sample size 59.3, mean age 44.2 years, 680 females). The CBMA detected no statistically significant consistency of CTh alterations in patients with migraine relative to HCs. Sensitivity analysis and subgroup analysis verified this result to be robust. Meta-regression analyses revealed that this CBMA result was not confounded by age, gender, aura, attack frequency per month, and illness duration. Conclusions Our CBMA adds to the evidence of the replication crisis in neuroimaging research that is increasingly recognized. The current evidence suggests that CTh is not a reliable biomarker of migraine. Many potential confounders, such as underpowered sample size, heterogeneous patient selection criteria, and differences in imaging collection and methodology, may contribute to the inconsistencies of CTh alterations in migraine, which merit attention before planning future research on this topic.

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Section: Discussionmentioning

confidence: 99%

Cortical thickness in migraine: a coordinate-based meta-analysis

Sheng

Shi³

et al. 2020

Preprint

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“…Measures of SBM have been associated with high consistency throughout aging [Fjell et al, ], and increased age‐related sensitivity as compared with traditional VBM methods [Hutton et al, ]. Nonetheless, recent SBM investigations have reported inconsistent findings in migraine patients as compared with healthy controls, reporting increased [DaSilva et al, ; Kim et al, ], reduced [Hougaard et al, ], or no change [Datta et al, ] in S1 cortical thickness. In contrast, Maleki et al [] compared high‐ with low‐frequency migraine patients.…”

Section: Discussionmentioning

confidence: 99%

In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation

Youssef

Ludwick

Wilcox

et al. 2017

Human Brain Mapping

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Over the past decade, human brain imaging investigations have reported altered regional cerebral blood flow (rCBF) in the interictal phase of migraine. However, there have been conflicting findings across different investigations, making the use of perfusion imaging in migraine pathophysiology more difficult to define. These inconsistencies may reflect technical constraints with traditional perfusion imaging methods such as single-photon emission computed tomography and positron emission tomography. Comparatively, pseudocontinuous arterial spin labeling (pCASL) is a recently developed magnetic resonance imaging technique that is non-invasive, offering superior spatial resolution and increased sensitivity. Using pCASL, we have previously shown increased rCBF within the primary somatosensory cortex (S1) in adult migraineurs, where blood flow was positively associated with migraine frequency. Whether these observations are present in pediatric and young adult populations remains unknown. This is an important question given the age-related variants of migraine prevalence, symptomology and treatments. In this investigation, we used pCASL to quantitatively compare and contrast blood flow within S1 in pediatric and young adult migraineurs as compared with healthy controls. In migraine patients, we found significant resting rCBF increases within bilateral S1 as compared with healthy controls. Furthermore, within the right S1, we report a positive correlation between blood flow value with migraine attack frequency and cutaneous allodynia symptom profile. Our results reveal that pediatric and young adult migraineurs exhibit analogous rCBF changes with adult migraineurs, further supporting the possibility that these alterations within S1 are a consequence of repeated migraine attacks.

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“…Compared to female healthy controls, increased primary somatosensory cortical thickness/gray matter density/volume has been observed in female patients with migraine (Kim et al 2014), IBS (Labus et al 2014; Labus et al 2015), IC/PBS (Kairys et al 2015), FM (Fallon et al 2013; Lutz et al 2008), and UCPPS (Bagarinao et al 2014). In addition, patients with dysmenorrhea demonstrate greater menstrual-related increases in primary somatosensory cortex gray matter volume compared to female healthy controls (Tu et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Sex‐based differences in brain alterations across chronic pain conditions

Gupta

Mayer

Fling

et al. 2016

J of Neuroscience Research

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Common brain mechanisms are thought to play a significant role across a multitude of chronic pain syndromes. In addition, there is strong evidence for the existence of sex differences in the prevalence of chronic pain and in the neurobiology of pain. Thus, it is important to consider sex when developing general principals of pain neurobiology. The goal of the current review is to evaluate what is known about sex-specific brain alterations across multiple chronic pain populations. A total of 15 sex difference and 143 single-sex manuscripts were identified out of 412 chronic pain neuroimaging manuscripts. Results from sex difference studies indicate more prominent primary sensorimotor structural and functional alterations in female chronic pain patients compared to male chronic pain patients; differences in the nature and degree of insula alterations, with greater insula reactivity in male patients; differences in the degree of anterior cingulate structural alterations; and differences in emotional-arousal reactivity. Qualitative comparisons of male-specific and female-specific studies appear to be consistent with the results from sex difference studies. Given these differences, mixed-sex studies of chronic pain risk creating biased data or missing important information and single-sex studies have limited generalizability. The advent of large scale neuroimaging databases will likely aid in building a more comprehensive understanding of sex differences and commonalities in brain mechanisms underlying chronic pain.

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Thickening of the somatosensory cortex in migraine without aura

Cited by 56 publications

References 43 publications

Cortical thickness in migraine: a coordinate-based meta-analysis

Cortical thickness in migraine: a coordinate-based meta-analysis

In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation

Sex‐based differences in brain alterations across chronic pain conditions

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