Thiazolidinedione compounds: a patent review (2010 – present)

Abstract

Diabetes management is very important as the number of diabetic patients increased and therefore the present research article will be very much useful for the development of new molecules.

Discovery of an Inhibitor for Bacterial 3-Mercaptopyruvate Sulfurtransferase that Synergistically Controls Bacterial Survival

“…The thiazolidinedione-type drugs identified in this study, pioglitazone, rosiglitazone, hydroxypioglitazone, and mitoglitazone, were found to be inhibitors of eMST. They are known agonists of peroxisome proliferator-activated receptor g (PPARg) and have an antidiabetic therapeutic effect via the amelioration of insulin resistance (Desai et al, 2015). Recently, they have also been found to possess an antimicrobial effect for bacteria (Masadeh et al, 2011), although the underlying molecular mechanism remains unknown.…”

Synthesis of Naphthyl‐, Quinolin‐ and Anthracenyl Analogues of Clofibric Acid as PPARα Agonists

“…The PPAR γ controls fatty acid storage and glucose metabolism by coordinating the expression of genes involved in lipid metabolism, adipogenesis and inflammation . This receptor is activated by the thiazolidinedione (TZD) antidiabetic drugs . PPAR β / δ regulates fatty acid catabolism, insulin sensitivity and energy homeostasis in muscle and adipose tissue .…”

Effect of Momordica charantia, Camellia sinensis and Cinnamon Species on Insulin Resistance

“…Only one kaempferol diglycoside kaempferitrin was reported to activate the insulin signaling pathway and stimulate secretion of adiponectin in 3T3-L1 adipocytes. Therefore, the insulin-like effects of two flavonol glycosides from C. osmophloeum leaves (CO-1 and CO-2), which are structurally different from previously reported kaempferitrin, were investigated on three of the proteins (adiponectin, IRβ and GLUT4) involved in insulin signal transduction pathway using mouse 3T3-L1 adipocytes [104].…”