Thiazolidin-4-one Derivatives as Central Nervous System Potential Agents

Kumar, Davinder; Kumar, Virender; Mundlia, Jyoti; Pradhan, Deepak; Malik, Sandeep

doi:10.2174/1871524915666150220111509

Cited by 7 publications

(4 citation statements)

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“…In addition, the S atom in the thiazolidinone ring can be oxidized to the sulfoxide or the sulfone to produce structures with different properties. Thiazolidinones have well documented biological activity (Thakare et al, 2018;Brown, 1961;Abdel Rahman et al, 1990;Joshi et al, 2014;Suryawanshi et al, 2017;Kaushal & Kaur, 2016;Kumar et al, 2015;Tripathi et al, 2014;Jain et al, 2012;Abhinit et al 2009;Hamama et al, 2008;Singh et al, 1981). The synthesis and characterization of these compounds could be valuable in investigations for the practical applications of their activities.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structures of two 1,3-thiazolidin-4-one derivatives featuring sulfide and sulfone functional groups

et al. 2018

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Section: Chemical Contextmentioning

confidence: 99%

Crystal structures of two 1,3-thiazolidin-4-one derivatives featuring sulfide and sulfone functional groups

et al. 2018

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“…Moreover, the availability of nitrogen and oxygen atoms has been utilized to improve the physical properties of biologically active compounds. [4] Among various heterocyclic compounds, thiazolidinones, which are a class of five-membered ring containing sulfur atom at position 1, nitrogen atom at position 3, and carbonyl group at positions 2, 4, or 5 [5] (Figure 1), is an advantaged pharmacophore possessing multiple biological activities, including anticancer, [6] antibacterial, [7] antifungal, [8] antiviral, [9] antidiabetic, [10] anticonvulsant, [11] antioxidant, [12] sedative, [13] anti-inflammatory, [14] antihypertension [15] and antituberculosis. [16] In addition, several drugs contain thiazolidinone moiety in their core structure such as Proglitazone, Rosiglitazone (antidiabetic), Darbufelone, CI-987 (dual COX/LOX inhibitors), and Actithiazic acid (antibiotic) [17] (Figure 2).…”

Section: Introductionmentioning

confidence: 99%

Thiazolidinone‐Heterocycle Frameworks: A Concise Review of Their Pharmacological Significance

2023

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Molecular hybridization is deemed an optimistic approach in drug design and the discovery of novel biologically active molecules as it may advance their affinity and potency while concurrently decreasing associated resistance and side effects. Approximately 20 % of approved drugs were developed using this approach in the past few years. Thiazolidinone is one of the privileged pharmacophores in medicinal chemistry and is associated with various biological activities; it forms a functional unit in several FDA-approved drugs. Consequently, this pharmacophore has attracted the attention of many research groups to further explore its pharmacological relevance by coupling it with other pharmacophoric moieties. This review presents a concise account of scholarly research exploits directed at the biological activities of newly synthesized thiazolidinone-tagged molecular hybrids. Focused attention is given to the existing structural activity relationship in each compound library and the toxicity profile of potent compounds including in silico docking studies (where applicable). This work would provide a base on which new pharmaceuticals with improved potency can be modelled.

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“…1,3-Thiazolidin-4-ones, also known as thiazolidin-4-ones, are known to have a very wide range of biological activity. (Suryawanshi et al, 2017) (Kaushal & Kaur, 2016) (Kumar, Kumar, Mundlia, Pradhan & Malik, 2015) (Tripathi et al, 2014) (Jain, Vaidya, Ravichandran, Kashaw, & Agrawal, 2012) (Abhinit, Ghodke & Pratima, 2009) (Hamama, Ismail, Shaaban & Zoorob, 2008) (Singh, Parmar, Raman, Virgil & Stenberg, 1981) (Brown, 1961), so much that some have referred to it as a "magic moiety" or "wonder nucleus" (Jain et al, 2012). .…”

Section: Introductionmentioning

confidence: 99%

Selective Synthesis of Substituted 3-Aryl-2-phenyl-1,3-thiazolidin-4-one Sulfoxides and Sulfones by S-Oxidation with Oxone

Cannon¹,

Costa²,

Pepper³

et al. 2017

IJC

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S-oxidation of 3-aryl-2-phenyl-1,3-thiazolidin-4-ones with Oxone® was investigated. For all compounds evaluated, selective oxidation to the sulfoxide was realized using 3 equivalents of Oxone® at room temperature. Alternatively, the sulfone was prepared selectively in most of the compounds evaluated at high temperature by increasing the equivalents of Oxone® used; the extent of this selectivity was affected by the substituent and its position on the N3 aromatic ring. The ratio of the sulfoxide and sulfone products was quantified by isolating the products by liquid chromatography.

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Thiazolidin-4-one Derivatives as Central Nervous System Potential Agents

Cited by 7 publications

References 0 publications

Crystal structures of two 1,3-thiazolidin-4-one derivatives featuring sulfide and sulfone functional groups

Crystal structures of two 1,3-thiazolidin-4-one derivatives featuring sulfide and sulfone functional groups

Thiazolidinone‐Heterocycle Frameworks: A Concise Review of Their Pharmacological Significance

Selective Synthesis of Substituted 3-Aryl-2-phenyl-1,3-thiazolidin-4-one Sulfoxides and Sulfones by S-Oxidation with Oxone

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