Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes

A green synthesis and antibacterial activity of ferrocene-based thiazole derivatives in choline chloride/glycerol eutectic solvent

“…Consequently, considerable synthetic efforts have been invested surrounding the thiazole ring for further modification and functionalization to enhance the potency of this class of heterocycles. 7 On the other hand, it has been well established that the introduction of ferrocene nucleus into organic heterocyclic compounds might often lead to a hybrid product with enhanced or unexpected activity compared to that of the parent compound. 8 This could be rationalized as being due to the unique properties of the ferrocene nucleus such as membrane permeation, aqueous stability, anomalous metabolism, and redox behaviour.…”

Synthesis of Benzothiazole Linked Triazole Conjugates and Their Evaluation Against Cholinesterase Enzymes

“…[18] Vitamine B1 (thiamine) contains thiazole moiety which helps in the normal functioning of the nervous system by its role in the synthesis of neurotransmitter acetylcholine (Ach). [6] Similarly, triazole, also known as pyrrodiazole, is one of the classes of N-heterocyclic compounds, which has also been noticed substantially by scientific community as an remarkable subunit of agrocheimcal and pharmaceutical products as well as fundamental structural motif of materials and dyes. [19][20][21][22][23][24][25][26][27][28][29][30] Triazole scaffold is utterly present as a key structural constituent in several drug molecules which acts as antimalarial, analgesic, antimicrobial, antiviral, antianxiety, antioxidant, anti-Parkinson's, antidiabatic agents, etc.…”

“…[1][2][3][4][5] Thiazoles and its derivatives represent highly significant class of N-heterocyclic molecules with a broad range of biological applications. [6][7][8] Thiazoles are key scaffolds of various drugs which includes bacitracin, penicillin, acinitrazole, sulfathiazole, [9] pramipexole, [10] bleomycin, Tiazofurin, [11] ritonavir, [12] cinalukast [13] and Nizatidine [14] etc. Moreover, thiazole derivatives such as Tetrahydrobenzothiazoles, [15] phenolic thiazoles [16] and benzothiazoles [17] have been successfully used as potential neuroprotective agents.…”

“…Moreover, thiazole derivatives such as Tetrahydrobenzothiazoles, [15] phenolic thiazoles [16] and benzothiazoles [17] have been successfully used as potential neuroprotective agents [18] . Vitamine B1 (thiamine) contains thiazole moiety which helps in the normal functioning of the nervous system by its role in the synthesis of neurotransmitter acetylcholine (Ach) [6] . Similarly, triazole, also known as pyrrodiazole, is one of the classes of N ‐heterocyclic compounds, which has also been noticed substantially by scientific community as an remarkable subunit of agrocheimcal and pharmaceutical products as well as fundamental structural motif of materials and dyes [19–30] .…”

“…Among the various class of heterocyclic compounds, N ‐atom based heterocyclic molecules are of much interest as these are broadly distributed in nature and are integral part of many alkaloids and medicinally important molecules such as vitamins, nucleic acids, pharmaceuticals, antibiotics, dye and agrochemicals, etc [1–5] . Thiazoles and its derivatives represent highly significant class of N ‐heterocyclic molecules with a broad range of biological applications [6–8] . Thiazoles are key scaffolds of various drugs which includes bacitracin, penicillin, acinitrazole, sulfathiazole, [9] pramipexole, [10] bleomycin, Tiazofurin, [11] ritonavir, [12] cinalukast [13] and Nizatidine [14] etc.…”