2018
DOI: 10.1007/s00198-018-4486-9
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Thiazide diuretic usage and risk of fracture: a meta-analysis of cohort studies

Abstract: Our findings indicate that thiazide diuretic use may convey a decreased risk of fracture and as such, the protective effect of this class of medicine should be considered when prescribing thiazide diuretics in clinical practice.

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Cited by 30 publications
(25 citation statements)
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“…Thus, it is important to focus on these medications when performing medication reviews in order to reduce the risk of medication related falls. Nevertheless, thiazides may also have a beneficial effect on bone strength by increasing renal calcium reabsorption [22]. The use of medications with an established bone-demineralizing effect, such as oral corticosteroids, aromatase inhibitors and enzymeinducing anti-epileptics, was infrequent in our population, suggesting a limited contribution to falls by these medications among hip fracture patients.…”
Section: (37)mentioning
confidence: 85%
“…Thus, it is important to focus on these medications when performing medication reviews in order to reduce the risk of medication related falls. Nevertheless, thiazides may also have a beneficial effect on bone strength by increasing renal calcium reabsorption [22]. The use of medications with an established bone-demineralizing effect, such as oral corticosteroids, aromatase inhibitors and enzymeinducing anti-epileptics, was infrequent in our population, suggesting a limited contribution to falls by these medications among hip fracture patients.…”
Section: (37)mentioning
confidence: 85%
“…Notable, some medications demonstrate opposite effects on bone metabolism and risk of falling. For instance, thiazide diuretics, beta-blockers, calcium-channel blockers and ACE inhibitors may contribute toward orthostatic hypotension, syncope and falls, but exert beneficial effect on mineral-bone metabolism and, paradoxically, may reduce fracture risk [ 547 , 552 , 589 , 590 , 591 , 592 , 593 , 594 , 595 , 596 , 597 , 598 ]. Some agents have shown divergent effects on bone and skeletal muscles.…”
Section: Hpi-associated Chronic Extra-gastroduodenal Diseases Medmentioning
confidence: 99%
“…Steroid and bisphosphonate use was slightly more common and thiazide use was less common in residents with a femoral shaft fracture compared with other LE fracture types. Thiazide diuretics have been associated with a decreased risk of LE fracture in immobile men with spinal cord injury and a decreased risk of hip fracture in community dwellers . Given the modest difference we found in medication use among the LE fracture types, it is unclear whether medications influence risk of nonhip LE fractures in NH residents.…”
Section: Discussionmentioning
confidence: 75%