Thiamphenicol disposition in pigs

Castells, G.; Prats, Carmen Hernández; Korchi, G El; Pérez, Belén; Arboix, M.; Cristòfol, Carles; Martí, G.

doi:10.1053/rvsc.1998.0263

Cited by 9 publications

(13 citation statements)

References 17 publications

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“…Meanwhile, a tendency of good distribution was also seen in other animal species with Vd ss values of 0.67 L/kg in non-lactating cows, 0.742-1.028 L/ kg in calves, 0.767 L/kg in cattle, 0.35 L/kg in lactating cows, 4.99 L/kg in the broiler chickens and 5.15 L/kg in ducks (Varma et al, 1986;Bretzlaff et al, 1987;Lobell et al, 1994;Soback et al, 1995;el-Banna, 1998;Shen et al, 2003). Interestingly, similar Vd ss values were reported for chloramphenicol (0.9549 ± 0.247 L/kg) in colostrum-fed newborn piglets and for thiamphenicol (0.62 ± 0.24 L/kg) in pigs with body weight of 26.6 ± 4.1 kg (Martin & Wiese, 1988;Castells et al, 1999). Liu et al (2003) observed t 1/2b of 2.63 ± 0.51 h (with t 1/2a of 0.64 ± 0.39 h) calculated with a best-fitted twocompartment model after an i.v.…”

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confidence: 55%

Pharmacokinetics of florfenicol in pigs following intravenous, intramuscular or oral administration and the effects of feed intake on oral dosing

Jiang

Zeng

Chen

et al. 2006

Vet Pharm & Therapeutics

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Florfenicol is a fluorinated analog of thiamphenicol and has been used for treatment of animal respiratory infectious diseases with a mechanism of action of inhibiting protein synthesis of bacterial peptidyl transferase specifically on 70 S ribosomes (Cannon et al., 1990;Varma et al., 1991;Ueda et al., 1995). With modifications based on the chemical structure of chloramphenicol, florfenicol has been shown to not only circumvent the bacterial acetyltransferase-mediated drug resistance but also to ameliorate the risk of inducing drug-related aplastic anemia in humans (Syriopoulou et al., 1981;Soback et al., 1995).Pharmacokinetics of florfenicol have been described in calves, cows, broiler chickens and muscovite ducks (Varma et al., 1986;Bretzlaff et al., 1987;Lobell et al., 1994;Soback et al., 1995;el-Banna, 1998;Shen et al., 2003). Recently, florfenicol tends to be increasingly used for treating porcine pneumonias caused by Actinobacillus pleuropneumoniae (Ueda et al., 1995;Liu et al., 2003) and Pasteurella multocida (Voorspoels et al., 1999). We wished to evaluate pharmacokinetics of florfenicol in pigs following intravenous (i.v.), intramuscular (i.m.) or oral (p.o.) administration and the potential feed-effect on its oral dosing.Twelve clinically-healthy crossbred pigs (Duroc · Landrace · Yorkshire) were housed in semi-contained pens with access to water ad libitum and a commercial nonmedicated chow at scheduled times. Pharmacokinetics of florfenicol was first studied in six animals (b.w., 24.7 ± 1.0 kg), which were divided into three groups according to the Latin square design. Each group of two animals received a single dose of florfenicol at 20 mg/kg via i.v., i.m. or p.o. administration sequentially, with a 10-day washout between treatments. An injection solution of florfenicol (300 mg/mL; Huihua, Guangzhou, China) was given i.v. via the ear vein or i.m. An amylum-based powder containing 15% florfenicol (Huihua) was given orally by gavage. Blood samples of each 5 mL were collected prior to the i.v. dosing and at 0.083, 0.167, 0.25, 0.5, 0.75, 1,, 1.5, 2, 3, 4, 6, 9, 12, 15, 24, 36 and 48 h thereafter; to the i.m. dosing and at 0.083, 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 9, 12, 15, 24, 36 and 48 h thereafter; to the p.o. doing and at 0.083, 0.5, 0.75, 1, 1.5, 2, 3, 4, 9, 12, 15, 24, 36 and 48 h thereafter, respectively. Plasma was prepared immediately and stored at )20°C until analysis.The effect of feed intake on the pharmacokinetics of florfenicol was next studied in six pigs (b.w., 15.3 ± 1.2 kg). Two groups of three animals were designated to undergo either fasting for 16 h or feeding for 1 h with the standard diet before they were orally given a single dose of florfenicol at 20 mg/kg. Blood samples were taken immediately prior to the drug treatment and at 0. 083, 0.5, 0.75,1, 2, 3, 4, 9, 12, 15, 24, 36 and 48 h thereafter, followed by the immediate preparation of plasma. After a 10-day washout, animals were crossover to the alternative condition followed a repetition of the above pharmacokinetic study....

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confidence: 55%

Pharmacokinetics of florfenicol in pigs following intravenous, intramuscular or oral administration and the effects of feed intake on oral dosing

Jiang

Zeng

Chen

et al. 2006

Vet Pharm & Therapeutics

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“…administration in sheep [13] and rabbits [14]. Some authors have been compared disposition kinetics only by intravenous and intramuscular routes in dogs [15] and pigs [16]. Furman et al have been described pharmacokinetics in patients during peritoneal dialysis after intramuscular injections in doses of 10-20 mg TAP/kg of body weight (bw) [17].…”

Section: Introductionmentioning

confidence: 99%

Capillary electrophoretic determination of thiamphenicol in turkeys serum and its pharmacokinetic application

Kowalski¹

2007

Journal of Pharmaceutical and Biomedical Analysis

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“…Nevertheless, most of the HPLC determinations were performed on a reversed stationary phase and all utilize UV at 223 or 224 nm using liquid-solid extraction have already been published [11,12]. Many HPLC methods based on single extraction with ethyl acetate [13][14][15][16][17] and with acetone [18] have been studied for quantitative analysis of florfenicol.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation between capillary electrophoresis and high-performance liquid chromatography for the analysis of florfenicol in plasma

Kowalski

Konieczna

Chmielewska

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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Thiamphenicol disposition in pigs

Cited by 9 publications

References 17 publications

Pharmacokinetics of florfenicol in pigs following intravenous, intramuscular or oral administration and the effects of feed intake on oral dosing

Pharmacokinetics of florfenicol in pigs following intravenous, intramuscular or oral administration and the effects of feed intake on oral dosing

Capillary electrophoretic determination of thiamphenicol in turkeys serum and its pharmacokinetic application

Comparative evaluation between capillary electrophoresis and high-performance liquid chromatography for the analysis of florfenicol in plasma

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