Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy

Novoa, Juan; Hardy, Gil; Manzanares, William

doi:10.1016/j.nut.2023.112000

Cited by 1 publication

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, there is a lack of substantial clinical evidence to endorse the regular administration of high-dose thiamine with the intention of enhancing outcomes in cases of septic shock. Hence, it is recommended that the administration of high-dose intravenous thiamine be limited to patients who have been confirmed to have a thiamine deficiency [11 ▪▪ ].…”

Section: Thiamine Deficiency During Critical Illnessmentioning

confidence: 99%

Metabolic failure due to thiamine deficiency during critical illness

Cobilinschi,

Andrei,

Grinţescu

et al. 2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

View full text Add to dashboard Cite

Purpose of review Thiamine is a crucial component in cellular energy metabolism, serving as a cofactor for multiple enzymatic processes and also having a role in regulating neuronal and neuromuscular transmission. Also it exerts antioxidant proprieties. The objective of this review is to consolidate and assess the most recent research concerning the consequences of insufficient thiamine levels for critically ill patients and to examine thiamine-related interventions. Recent findings Recent studies have unveiled a noteworthy association between thiamine deficiency and unfavorable consequences, such as heightened morbidity and fatality rates. The aforementioned deficiency exhibits a significant presence in medical situations such as starvation and alcohol use disorder, but also in patients during critical illness. Thiamine deficiency can have significant metabolic implications resulting in compromised energy generation and organ dysfunction, warranting prompt recognition and management. Summary Thiamine deficiency may not be recognized in critical care. Timely identification and management are imperative to mitigate adverse outcomes and improve patient prognosis. Thiamine may offer benefits for specific patient groups at higher risk of deficiency. Future studies should focus to establish optimal dosing, timing, and monitoring strategies on understanding the pathophysiological changes associated with thiamine deficiency in ICU patients and clarify its role in improving clinical outcomes.

show abstract

Section: Thiamine Deficiency During Critical Illnessmentioning

confidence: 99%