Thiamine-deficient encephalopathy due to excessive intake of isotonic drink or overstrict diet therapy in Japanese children

Saeki, Keisuke; Saito, Yoshiaki; Komaki, Hirofumi; Sakakibra, Takafumi; Nakagawa, Eiji; Sugai, Kenji; Sakuma, Hiroshi; Sasaki, Masayuki; Honda, Takashi; Hayashi, Hatsuka; Katori, Nobutada; Miyahara, Yoko

doi:10.1016/j.braindev.2009.08.004

Cited by 13 publications

(13 citation statements)

References 15 publications

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“…We recently reported that vitamin B1 deficiency (VB1D) could be caused by the excessive consumption of soft drinks, mainly ionic beverages, in a Japanese cohort of patients . This was in line with previous reports in Japan . Patients with VB1D were more often infants and young children who continued to drink a large amount of ionic beverages each day for several months, with some being raised in a non‐nurturing environment.…”

supporting

confidence: 89%

“…1 This was in line with previous reports in Japan. [2][3][4][5][6][7][8][9][10] Patients with VB1D were more often infants and young children who continued to drink a large amount of ionic beverages each day for several months, with some being raised in a non-nurturing environment. VB1D caused by excessive soft drink consumption is presumed to be unique to Japan and is associated with the popularity of ionic beverages.…”

mentioning

confidence: 99%

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Parental awareness of young children's pattern of ionic beverage consumption

Okumura

Ida

Ito

et al. 2018

Pediatrics International

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supporting

confidence: 89%

mentioning

confidence: 99%

Parental awareness of young children's pattern of ionic beverage consumption

Okumura

Ida

Ito

et al. 2018

Pediatrics International

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“…Wernicke's encephalopathy occurs in children that suffer from malnutrition or malabsorption conditions in the context of gastrointestinal surgical procedures, prolonged total parenteral nutrition with low contents of thiamine, malignancies, organ transplantations, pancreatitis, etc. [39][40][41][42] A minority of children presents with the triad of ataxia, ophthalmoplegia and decreased consciousness. 4 Most commonly, mental status changes are present in isolation at the beginning of symptoms.…”

Section: Wernicke's Encephalopathymentioning

confidence: 99%

Genetic defects of thiamine transport and metabolism: A review of clinical phenotypes, genetics, and functional studies

Marcé‐Grau

Martí-Sánchez

Baide‐Mairena

et al. 2019

J of Inher Metab Disea

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Thiamine is a crucial cofactor involved in the maintenance of carbohydrate metabolism and participates in multiple cellular metabolic processes within the cytosol, mitochondria, and peroxisomes. Currently, four genetic defects have been described causing impairment of thiamine transport and metabolism: SLC19A2 dysfunction leads to diabetes mellitus, megaloblastic anemia and sensory‐neural hearing loss, whereas SLC19A3, SLC25A19, and TPK1‐related disorders result in recurrent encephalopathy, basal ganglia necrosis, generalized dystonia, severe disability, and early death. In order to achieve early diagnosis and treatment, biomarkers play an important role. SLC19A3 patients present a profound decrease of free‐thiamine in cerebrospinal fluid (CSF) and fibroblasts. TPK1 patients show decreased concentrations of thiamine pyrophosphate in blood and muscle. Thiamine supplementation has been shown to improve diabetes and anemia control in Rogers' syndrome patients due to SLC19A2 deficiency. In a significant number of patients with SLC19A3, thiamine improves clinical outcome and survival, and prevents further metabolic crisis. In SLC25A19 and TPK1 defects, thiamine has also led to clinical stabilization in single cases. Moreover, thiamine supplementation leads to normal concentrations of free‐thiamine in the CSF of SLC19A3 patients. Herein, we present a literature review of the current knowledge of the disease including related clinical phenotypes, treatment approaches, update of pathogenic variants, as well as in vitro and in vivo functional models that provide pathogenic evidence and propose mechanisms for thiamine deficiency in humans.

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“…33,34 Vitamin deficiencies affect more patients who have comorbid psychiatric and medical conditions than patients who have medical conditions alone. 35 This could be due in part to lack of knowledge about the importance of eating a balanced diet and/or limited resources and motivation to eat healthy food.…”

Section: Discussionmentioning

confidence: 99%

Beyond Alcoholism

McCormick

Buchanan

Onwuameze

et al. 2011

Cognitive and Behavioral Neurology

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Objective Wernicke encephalopathy and Korsakoff syndrome (the combined disorder is named Wernicke-Korsakoff syndrome [WKS]) are preventable, life-threatening neuropsychiatric syndromes resulting from thiamine deficiency. WKS has historically been associated with alcoholism; more recently, it has been recognized in patients who have anorexia nervosa or have undergone bariatric surgery for obesity. However, patients with nutritional deficiencies of any origin are at risk for WKS. We present clinical histories and neuroimaging data on 2 young adults with underlying psychiatric disorders who became malnourished and developed WKS. Methods A young woman with bipolar disorder and somatization disorder was hospitalized for intractable vomiting. A young man with chronic paranoid schizophrenia developed delusions that food and water were harmful, and was hospitalized after subsisting for 4 months on soda pop. Results Acute, life-threatening Wernicke encephalopathy was confirmed in both patients by brain magnetic resonance imaging showing classic thalamic injury. The patients were left with persistent cognitive and physical disabilities that were consistent with Korsakoff syndrome. Conclusions Failure to suspect a vitamin deficiency led to permanent cognitive and physical disabilities that may necessitate lifelong care for these patients. The neuropsychiatric consequences could have been prevented by prompt recognition of their thiamine deficiency.

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Thiamine-deficient encephalopathy due to excessive intake of isotonic drink or overstrict diet therapy in Japanese children

Cited by 13 publications

References 15 publications

Parental awareness of young children's pattern of ionic beverage consumption

Parental awareness of young children's pattern of ionic beverage consumption

Genetic defects of thiamine transport and metabolism: A review of clinical phenotypes, genetics, and functional studies

Beyond Alcoholism

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