Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: A pilot study

Seligmann, H; Halkin, Hillel; S, Rauchfleisch; N, Kaufmann; Tal, Rachel; Motro, Michael; Vered, Zvi; Ezra, David

doi:10.1016/0002-9343(91)90007-k

Cited by 187 publications

(150 citation statements)

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“…Studies of low thiamine compound levels include association with oxidative stress, sepsis, metabolic acidosis, cardiac failure, and neurodegeneration [16,62,[72][73][74]. The prevalence of TD in the ICU, hospitals and the elderly (>76 years of age) has also been examined [15,75,76].…”

Section: Pathophysiology Related To Tdmentioning

confidence: 99%

“…Ahmed et al [3] reviewed the prevalence of TD in cardiac failure patients reporting an overall prevalence of 33%-91% in those that are hospitalised and 21%-27% in a consortium of inpatients and outpatients with cardiac failure. Multiple studies have shown improvement with supplementation whilst others show no difference between the disease and non-disease groups [64,73,[82][83][84][85]. 1.…”

Section: Cardiac Failure and Surgerymentioning

confidence: 99%

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Vitamin B1 in critically ill patients: needs and challenges

Collie

Greaves

Jones

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Thiamine has a crucial role in energy production, and consequently thiamine deficiency (TD) has been associated with cardiac failure, neurological disorders, oxidative stress (lactic acidosis and sepsis) and refeeding syndrome (RFS). This review aims to explore analytical methodologies of thiamine compound quantification and highlight similarities, variances and limitations of current techniques and how they may be relevant to patients. Content: An electronic search of Medline, PubMed and Embase databases for original articles published in peerreviewed journals was conducted. MethodsNow was used to search for published analytical methods of thiamine compounds. Keywords for all databases included "thiamine and its phosphate esters", "thiamine methodology" and terms related to critical illness. Enquiries were also made to six external quality assurance (EQA) programme organisations for the inclusion of thiamine measurement.

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Section: Pathophysiology Related To Tdmentioning

confidence: 99%

Section: Cardiac Failure and Surgerymentioning

confidence: 99%

Vitamin B1 in critically ill patients: needs and challenges

Collie

Greaves

Jones

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

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“…There are some evidences that heart failure patients might be thiamine deficient in comparison to healthy controls [4][5][6][7][8][9][10]; Heart failure patients tend to have inadequate nutrient intake [3][4][5], on the other hand, loop [4,5,[11][12][13][14][15][16] and all other diuretics [11,15] that may be used in heart failure may cause the hyperexcretion of thiamine [2,4,5,[13][14][15]17], hence chronic diuretic treatment has been related to thiamine deficiency in a high risk patient (such as an elderly) in some [2,6,11,13,17,18] but not all of the studies [7,19,20]. Thiamine deficiency further impairs cardiac performance in heart failure [13], and can mimic its signs and symptoms [5].…”

Section: Introductionmentioning

confidence: 99%

“…Thiamine deficiency further impairs cardiac performance in heart failure [13], and can mimic its signs and symptoms [5]. It is possible that thiamine supplementation has some useful effects in the patients with heart failure [2,3,17] by prevention or correction of thiamine deficiency in heart failure [4,13,14], but this is controversial [2,4,7,17,21].…”

Section: Introductionmentioning

confidence: 99%

Thiamine Supplementation in Patients with Chronic Heart Failure Receiving Optimum Medical Treatment

2017

JCCR

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Background: Thiamine deficiency may cause heart failure and symptoms including edema, palpitation, tachycardia, weakness, malaise, and dyspnea due to water and salt retention and peripheral vasodilation. Patients with heart failure might be thiamine deficient and benefit thiamine supplementation. This study was designed to evaluate the effect of thiamin supplementation on some systolic and diastolic echocardiographic parameters and signs and symptoms of heart failure.Methods: Fifty two patients with systolic heart failure (LVEF < 40%) receiving optimum medical treatment, were randomized to receive 300mg thiamine or placebo for 1 month in a double-blind fashion (26 patients in each group). Echocardiographies were performed before and after treatment by a single investigator and sign and symptoms were evaluated (clinicaltrials.gov Identifier # NCT01115504). Results:Mean age was 61.44 ± 11.8 years and 67.3% were male. Maximal systolic tissue velocity of of septal and lateral walls (Sm waves) increased 0. 99 ± 1.46 and 0.83 ± 1.58 cm/s in thiamine group and changed 0.005± 1.63 and -0.1 ± 1.83 cm/s in placebo group (P = 0.033 and P = 0.044) respectievely. Ejection fraction or diastolic echocardiographic parameters were not influenced by thiamine supplementation and there was no significant effect on daily activities and dyspnea. However, peripheraledema improved in 9 patients (34.6%) of thiamine group versus 1 of the placebo group (3.8%) (P = 0.005). Conclusion:In the present study thiamine supplementation had some positive effect on edema and systolic function through an increase of lateral and septal Sm. However usefulness of routine supplementation needs more study Keywords: Thiamine; Heart failure; Edema; Signs and Symptoms, regimen of the patients in the past 3 months, due to aggravated symptoms or optimization of dosage for a survival benefit according to the present guidelines. Excluded patients were those with decompensated heart failure, bradycardia or tachycardia (needing a change in drug dosage or regimen), concomitant medical illness e.g. chronic renal failure, chronic obstructive pulmonary disease, asthma and uncontrolled hypertension.The study was a single-site randomized placebo-controlled double blind trial and enrolled patients were randomized by means of block randomization method by a single pharmacist. Patients were assigned to randomly receive 300mg daily of thiamine (HakimVitamin B1300®, Hakim pharmaceutical industry, Tehran, Iran) (n=26, thiamine group) or placebo (Hakim pharmaceutical industry, Tehran, Iran) (n=26, placebo group) for 30 days in a double-blind fashion.At randomization and at the end of study, echocardiography (Sonace 8000 EX, South Korea) was performed by a single operator in a blinded fashion. Ejection fraction was measured in 2D echocardiography in apical 4 chamber and apical 2 chamber views by means of Simpson method. Maximal systolic velocity of myocardial tissue of septal and lateral walls (Sm waves) were obtained by tissue Doppler imaging of lateral and septal wal...

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“…First, diuretics, nearly ubiquitous in HF management, increase excretion of and contribute to deficiencies in water‐soluble vitamins, such as thiamine 12. Although the analysis adjusted for HF severity using the Seattle Heart Failure Model score, which includes diuretic prescription and dosing,13 the dietary model likely underestimated the true severity of some micronutrient deficiencies in HF.…”

Section: Introductionmentioning

confidence: 99%