Thiamine deficiency in congestive heart failure

Levy, Wayne C.; Soine, Laurie A.; Huth, Mark; Fishbein, Daniel P.

doi:10.1016/0002-9343(92)90212-t

Cited by 25 publications

(25 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yiu et al 16 first described increased loses of thiamine secondary to loop diuretic therapy. Since then several other studies 10,13,17 have replicated these findings suggesting that loop diuretic therapy can lead to thiamine deficiency mainly secondary to hyperexcretion.…”

Section: Discussion:-mentioning

confidence: 89%

See 1 more Smart Citation

Role of Thiamine Deficiency and Efficacy of Thiamine in Treatment of Patients With Heart Failure.

Iqbal¹,

Abdullah²,

Nuzhat³

et al. 2017

IJAR

View full text Add to dashboard Cite

Thiamine is a water soluble B-complex vitamin readily available in cereal grains, yeast, nuts and meat products. It combines with adenosine triphosphate in liver, kidneys and leukocyte to form thiamine pyrophosphate, a coenzyme in carbohydrate metabolism 1 .Diagnosis of thiamine deficiency is frequently obtained by measuring thiamine pyrophosphate effect (TPPE). TPPE reflects thiamine concentrations on the basis of activity of thiamine diphosphate on the transketolase enzyme of pentose shunt 2 .A thiamine pyrophosphate effect of 0 to 15% is considered normal, 15% to 24% indicative of marginal deficiency, and >25% associated with several deficiency 3 .Thiamine status can be assessed also by direct measurement of thiamine pyrophosphate in erythrocytes or whole blood by high performance liquid chromatography (HPLC). This method is precise and yields results similar to erythrocyte activation assay 4 .Specific signs and symptoms observed in thiamine-deficient patients represent alterations in the biochemistry of thiamine that result in impaired oxidative phosphorylation, increased levels of proximal metabolites (pyruvate), and decreased transketolase activity in RBCs, liver, heart and other organs. Thiamine deficiency manifests as dry or wet beri beri. Dry beri beri involves peripheral neuropathy that can be permanent even following thiamine repletion. Neurological side effects of thiamine deficiency can progress to Wernicke-koraskoff syndrome 5 .Heart failure (HF) is a common, disabling and costly disease throughout the world. The recommended pharmacological therapy includes the use of angiotensin converting enzyme inhibitors, angiotensin receptor

show abstract

Section: Discussion:-mentioning

confidence: 89%

“…The issue of age as a factor contributing to the prevalence of thaimien deficiency was evaluated by Levy et al 17 who conducted a prospective trial of patients with a mean age of 47+10 years, NYHA class of 2.5+0.6 and mean LVEF of 22+9%. No evidence of thiamine deficiency was fund in their population of heart failure patients.…”

Section: Discussion:-mentioning

confidence: 99%

Role of Thiamine Deficiency and Efficacy of Thiamine in Treatment of Patients With Heart Failure.

Iqbal¹,

Abdullah²,

Nuzhat³

et al. 2017

IJAR

View full text Add to dashboard Cite

show abstract

“…This syndrome mimics the signs and symptoms of HF; therefore, thiamin deficiency may actually exacerbate underlying HF. In fact, research has shown that when thiamin deficiency is corrected, LVEF improves 6 , 16 – 18 . Ejection fraction is one of the most widely used predictors of prognosis; patients with reduced LVEF typically have poor outcomes.…”

Section: Characteristics Of Thiaminmentioning

confidence: 99%

“…The issue of age as a factor contributing to the prevalence of thiamin deficiency was evaluated by Levy et al 16 who conducted a prospective trial of patients with a mean age of 47 ± 10 years, mean New York Heart Association (NYHA) functional class of 2.5 ± 0.6 on a scale of I‐IV, and mean LVEF of 22 ± 9% (normal LVEF> 50% 8 ). The mean dosage of loop diuretics (mainly furosemide) was 184 mg/day.…”

Section: Characteristics Of Thiaminmentioning

confidence: 99%

Characteristics of Thiamin and Its Relevance to the Management of Heart Failure

Wooley

2008

Nut in Clin Prac

View full text Add to dashboard Cite

Heart failure (HF) is a major public health problem in the United States that puts a significant burden on both patients and the healthcare system. The prevalence of malnutrition in HF patients is well-known and correlates with a dramatic decline in quality of life and disease progression, and is associated with high morbidity and mortality rates. The implication of HF on micronutrient status is underrecognized in the quest to offer "best practice" medical, device, and surgical interventions to this population. The micronutrient thiamin is of particular interest in the management of HF for several reasons: (a) HF is a disease of the elderly whose micronutrient status is in need of attention; (b) HF patients tend to have inadequate nutrient intake, which has been associated with thiamin deficiency; (c) thiamin deficiency (wet beriberi) impairs cardiac performance and can mimic the signs and symptoms of HF thereby potentially exacerbating the underlying disease; (d) use of loop diuretics to manage fluid and sodium imbalances associated with HF may cause the hyperexcretion of thiamin, thereby increasing the risk of deficiency; and (e) the prevention of thiamin deficiency should be a routine component in the overall management of this disease.

show abstract

“…Although thiamin adequacy is normally achieved in healthy subjects eating according to present guidelines (IOM, 1998), thiamin (compared with other nutrients), represents a nutrient with very high potential for deficiency . In particular, older adults are at especially high risk for the development of thiamin deficiency (Kwoh, Falconer-Smeith, Potter, & Ives, 1992;Levy, Soine, Huth, & Fishbein, 1992). The increased risk for thiamin deficiency among older persons may result from a disproportionately high prevalence of multiple chronic diseases, overnight hospitalizations, and the use of prescription medications from a large number of therapeutic categories (Barrocas, Jastram, & McCabe, 2003;DeBrew, Barba, & Test, 1998).…”

Section: Introductionmentioning

confidence: 98%

Diuretic Medication Therapy Use and Low Thiamin Intake in Homebound Older Adults

McCabe‐Sellers

Sharkey

Browne

2005

Journal of Nutrition For the Elderly

View full text Add to dashboard Cite

Diuretic therapy (DT) plays a major role in disease management. However, one issue of concern in nutritionally vulnerable elders is that diuretic therapy also increases thiamin excretion, and little attention has been paid to the linkage between DT use and dietary intake of thiamin in this older population. The purpose of this study was to assess the relationship between DT use and dietary intake of thiamin in a randomly recruited sample of 342 homebound older adults. Baseline data, including three 24-hour recalls, were used to identify thiamin intake from food (15% < EAR and 33% < RDA), DT use (49%), and meal pattern (18% not regularly eating breakfast). Independent of sociodemographic and meal pattern variables, DT users (relative to non-users) were at increased odds for dietary thiamin intake < RDA (OR = 2.3) and < EAR (OR = 4.2). Considering the importance of home-delivered meals as a primary source of food assistance to homebound elders and that thiamin deficiency may exacerbate health problems, the results of this study suggest the need to include information on DT use as an integral component of program assessment for the targeting and monitoring of strategies to alleviate the risk for deficiency.

show abstract

Thiamine deficiency in congestive heart failure

Cited by 25 publications

References 2 publications

Role of Thiamine Deficiency and Efficacy of Thiamine in Treatment of Patients With Heart Failure.

Role of Thiamine Deficiency and Efficacy of Thiamine in Treatment of Patients With Heart Failure.

Characteristics of Thiamin and Its Relevance to the Management of Heart Failure

Diuretic Medication Therapy Use and Low Thiamin Intake in Homebound Older Adults

Contact Info

Product

Resources

About