Thiamine Deficiency and Cardiac Dysfunction in Cambodian Infants

Porter, Samuel G.; Coats, Debra; Fischer, Philip R.; Ou, Kevanna; Frank, Elizabeth L.; Sreang, Phivan; Saing, Soksan; Topazian, Mark D.; Enders, Felicity; Cabalka, Allison K.

doi:10.1016/j.jpeds.2014.01.049

Cited by 30 publications

(47 citation statements)

References 24 publications

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“…However, both sets of Cambodian mothers and infants had significantly lower ThDP than the Americans . Other cases of infantile beriberi have been reported in this same clinic in Mesang District in Prey Veng, as well as at a clinic in Siem Reap province …”

Section: Prevalence Of Thiamine Deficiency and Burden Of Tddsmentioning

confidence: 69%

“…Infantile beriberi is rare in the first 2 months of life, as thiamine levels are higher in newborns, and then falls rapidly in the third month of life, likely due to changes in metabolic activity . It has been recognized in areas of Central and Southeast Asia, especially in Myanmar, Laos, and Cambodia; but, TDDs have also been observed in West Africa, Angola, Mayotte Island, Kiribati, Cuba, and parts of the Caribbean, and may go unrecognized in other settings …”

Section: Thiamine Deficiency and Its Consequencesmentioning

confidence: 99%

“…Based on existing biomarker studies and case reports of thiamine‐responsive conditions, along with information on the use of polished rice or cassava as primary staples in the diets of many poor households in LMIC, risk of thiamine deficiency is thought to be of potential public health importance in many communities in Southeast Asia (e.g., Cambodia, Laos, and Myanmar), South Asia (e.g., Nepal and Northern India), and West Africa …”

Section: Prevalence Of Thiamine Deficiency and Burden Of Tddsmentioning

confidence: 99%

“…Suboptimal thiamine status has been called the “forgotten disease of Asia,” as reports of TDDs in the region are common despite the known etiology and relatively straightforward approaches to prevention and treatment . There is current evidence of suboptimal thiamine intake or status in Southeast Asia, notably in Cambodia, Laos, and Myanmar, parts of India, and in recent reports of Karen refugees upon their arrival in the Mae La Camp on the Thai‐Myanmar border …”

Section: Thiamine Status Assessment Decision Treementioning

confidence: 99%

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Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Whitfield

Bourassa

Adamolekun

et al. 2018

Annals of the New York Academy of Sciences

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231

335

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Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.

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Section: Prevalence Of Thiamine Deficiency and Burden Of Tddsmentioning

confidence: 69%

Section: Thiamine Deficiency and Its Consequencesmentioning

confidence: 99%

Section: Prevalence Of Thiamine Deficiency and Burden Of Tddsmentioning

confidence: 99%

Section: Thiamine Status Assessment Decision Treementioning

confidence: 99%

See 2 more Smart Citations

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Whitfield

Bourassa

Adamolekun

et al. 2018

Annals of the New York Academy of Sciences

Self Cite

231

335

View full text Add to dashboard Cite

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“…8,9 We analyzed blood samples in tachypneic and healthy control infants for camphor concentrations, testing the hypothesis that camphor from Tiger Balm use could stimulate tachypnea in Cambodian children. Failure to detect even trace amounts of camphor in blood samples suggests camphor toxicity is unrelated to symptomatic clinical illness in these children.…”

Section: Discussionmentioning

confidence: 99%

No Camphor Toxicity in Cambodian Infants

Johnson

Porter

Coats³

et al. 2017

Global Pediatric Health

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Thiamine deficiency and beriberi are prevalent in Cambodia, although most infants with nonspecific clinical symptoms of beriberi, including tachypnea, lack echocardiographic evidence diagnostic of the disease. Camphor activates transient receptor potential vanilloid 3 (TRPV3), a nonselective ion channel expressed in the medial preoptic nucleus of the hypothalamus and thought to be important for thermo-sensitivity. Because camphorated ointments are used commonly among Cambodian infants, we hypothesized that topical camphor modulates thermoregulatory behaviors, causing beriberi-simulating tachypnea, separate from any influence of thiamine deficiency. We assessed 9 tachypneic and 10 healthy infants for Tiger Balm use and for presence of camphor in whole blood. However, no camphor was found in blood from any infants, indicating that camphor is unrelated to tachypneic illness in Cambodian infants.

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