Thiamine and the Cellular Energy Cycles — A Novel Perspective on Type 2 Diabetes Treatment

Alam, Saadia Shahzad; Riaz, Saira

doi:10.5772/59224

Cited by 1 publication

(1 citation statement)

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“…The low level of thiamine in diabetes may be due to the fact that decreased level of apo-enzyme from the disease itself instead of thiamine deficiency [9]. Furthermore, plasma thiamine level has been revealed to be reduced by 75% in type II diabetes and 76% in type I and that was related to higher renal clearance and partial elimination of thiamine from the body [22].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Serum Thiamine with Physical and Biochemical Parameters among Type 1 and Type 2 Diabetes

Bilal¹,

Raza

Khan³

et al. 2022

JPRI

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Objective: Thiamine or vitamin B1 is a fundamental vitamins and minerals and enzyme cofactor that are needed for most of the anabolic and catabolic reaction that occurs in organisms. Deficiency of Thiamine has been associated with numerous complications in diabetes mellitus (DM) patients. Therefore, this study was intended to assess various biochemical and anthropometric parameters with serum thiamine levels in patients with type I and type II diabetes. Methodology: This was a case-control study carried out in outpatient department (OPD) of Diabetes Department of Jinnah post graduate medical institute, Karachi by using non-probability convenient sampling technique. This study comprised of 6 months duration after approval of synopsis. A total of 60 participants with type I and II diabetes mellitus of both genders with age < 25 to > 46 years were selected; 30 participants with type I diabetes whereas 30 participants had type II diabetes. The Pearson’s correlation test was used to interpret correlation between thiamine levels and height, weight, heart rate, temperature, Total cholesterol, Triglycerides, creatinine, urea in type I and II diabetic patients. Results: The results showed that among type I diabetics, none of the patient characteristics studied were significantly correlated with the thiamine levels of these patients. On the other hand, among type II diabetics, significantly negative correlation was observed between height and thiamine level (p=0.045) where patients with greater height had lower thiamine level and vice versa. Moreover, both heart rate and total cholesterol were marginally insignificantly correlated with thiamine level (p=0.065 and p=0.069), respectively. Conclusion: This study concluded that all anthropometric and biochemical parameters were insignificantly correlated with thiamine levels in type I and II diabetes patients. However, height had significant negative correlation with the thiamine level among type II diabetics reflecting patients with more height had lower thiamine level.

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Section: Introductionmentioning

confidence: 99%