Thiamethoxam, a Neonicotinoid Poisoning Causing Acute Kidney Injury via a Novel Mechanism

Sakthirajan, Ramanathan; M, Senthil Kumar; Sanjeevi, Gopal; Narayanan, Babu; Kurien, Abraham

doi:10.1016/j.ekir.2020.04.009

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…Although one human case of acute kidney injury was reported due to oral ingestion of thiamethoxam,15 this case report is the first to describe the symptoms of thiamethoxam intoxication due to occupational inhalational exposure; the patient was followed up for more than 8 months to monitor the symptoms and levels of thiamethoxam and clothianidin. In patients who work as pest control operators, clinicians should assess for history of neonicotinoid use and consider the diagnosis of neonicotinoid intoxication.…”

Section: Discussionmentioning

confidence: 94%

Thiamethoxam intoxication due to occupational inhalational exposure

Nishizawa

Ikenaka

Ichikawa³

et al. 2022

BMJ Case Rep

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Neonicotinoid is a new class of systemic insecticides that are selectively toxic to insects. However, cases of human toxicity have been reported. A man in his 60s, who worked as a pest control operator (which required the use of thiamethoxam), presented with fever and headache. We investigated the levels of thiamethoxam and clothianidin in the blood and urine. Our results suggested that chronic thiamethoxam intoxication was caused by occupational inhalation exposure and environmental pollution. After cessation of insecticide use, the patient remained asymptomatic but had persistent oral dysesthesia and postural finger tremor, even at undetectable levels of thiamethoxam and clothianidin. This case report is the first to describe human thiamethoxam intoxication after occupational inhalation exposure. When similar symptoms are encountered and a history of insecticide use is confirmed, clinicians should consider the diagnosis of neonicotinoid intoxication.

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Section: Discussionmentioning

confidence: 94%

Thiamethoxam intoxication due to occupational inhalational exposure

Nishizawa

Ikenaka

Ichikawa³

et al. 2022

BMJ Case Rep

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“…In addition, we found a decreasing trend of Hb with THX and CLO when all other chemicals were at their median levels in the univariate exposureresponse function (data not shown). A recent study reported that THX poisoning causes acute kidney injury in proximal tubules by inhibiting the α7 nicotinic receptor [70,71]. CLO was reported to be a specific metabolite of THX [72], and the urinary concentrations of THX and CLO were strongly correlated [60].…”

Section: Associations Between Insecticide Exposure and Haematological Parametersmentioning

confidence: 99%

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Suwannarin

Prapamontol

Isobe

et al. 2021

IJERPH

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Exposure to insecticides may result in various health problems. This study investigated the association between haematological parameters and exposure to a mixture of organophosphate (OP) and neonicotinoid (NEO) insecticides among male farmworkers in Fang district, Chiang Mai province, northern Thailand. Concentrations of urinary dialkylphosphates, non-specific metabolites of OPs, and NEOs and their metabolites and haematological parameters were measured in 143 male farmworkers. The Bayesian kernel machine regression model was employed to evaluate the associations. Exposure to a mixture of insecticides was significantly associated with the mean corpuscular haemoglobin concentration (MCHC) when the concentrations of all the compounds and their metabolites were at the 60th percentile or higher compared with the 50th percentile. Furthermore, exposure to clothianidin (CLO) showed a decreasing association with MCHC when all the other insecticides were at their mean concentrations. CLO was the most likely compound to reduce MCHC, and this was confirmed by sensitivity analysis. These findings suggest that exposure to NEO insecticides, especially CLO, affects the haematological status relating to haemoglobin parameters.

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“…Along with 7.86% samples having pesticide residues more than MRL and 91% samples were found no pesticide residues of total tested samples. The detected pesticide thiamethoxam, tricyclazole, clothianidin, and imidacloprid can lead to acute kidney injury by tubular toxicity through α7 nicotinic receptor inhibition, rhabdomyolysis, leucocytoclastic vacuities and secondary sepsis(Ramanathan et al 2020;Iyyadurai et al 2010;Bansal et al 2019;Agha et al 2012). Hence, it is required to monitor pesticide residues in different agricultural crops to have good health of citizen and trade as well.…”

mentioning

confidence: 99%

Quantitation of Pesticides in 89 Rice Samples by Liquid Chromatography– Mass Spectrometry: Analysis of Delhi NCR

Temak,

Kapahi,

Rani

et al. 2024

Preprint

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Aim: To study the quantification of pesticides in 89 rice samples using liquid chromatography–mass spectrometry. Introduction: Monitoring pesticide residue in food matrices at very low concentrations is challenging work for an analyst and requires a valuable analytical technique. Material and Methods: In the current study, the dispersive solid– liquid extraction method was employed for quantification of different pesticides by liquid chromatography with tandem mass spectrometry (LC-MS/MS) electrospray ionization (ESI) (with a minimum run time of 10 minutes). Results: Twenty-two molecules were identified in the eighty-nine samples collected from different locations in the Delhi NCR region. Of these, eight samples were found to be contaminated with pesticide residues such as clothianidin (avg.conc. of 0.063 mg/kg), imidacloprid (avg. conc. of 0.064 mg/kg), thiamethoxam (avg. conc. 0.051 mg/kg), and tricyclazole (avg. conc. 0.044 mg/kg). Clothianidin and imidacloprid were found to be below the maximum residual limit (MRL) value, whereas thiamethoxam and tricyclazole were found to be above the MRL values as per the EU Guidelines. Conclusion: The limit of detection (LOD) and limit of quantification (LOQ) were 0.0025 and 0.005 mg/kg, respectively. The mean recovery was found to be within the range of 70-120% as per the SANTE 11312 guideline.

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Thiamethoxam, a Neonicotinoid Poisoning Causing Acute Kidney Injury via a Novel Mechanism

Cited by 10 publications

References 6 publications

Thiamethoxam intoxication due to occupational inhalational exposure

Thiamethoxam intoxication due to occupational inhalational exposure

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Quantitation of Pesticides in 89 Rice Samples by Liquid Chromatography– Mass Spectrometry: Analysis of Delhi NCR

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