Thiadiazole as an Antimicrobial Scaffold

Kaur, Parminder; Kaur, Rajwant

doi:10.36295/asro.2020.231542

Cited by 1 publication

(3 citation statements)

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“…These observed are compatible with the literature[25][26][27]. The chemical shift values are presented in Table3 1. H NMR values of the compounds (δ, ppm, in nDMSO-d6).…”

supporting

confidence: 89%

“…Infrared spectra were recorded with a Bruker Alpha Fourier transform FT-IR spectrometer. 1 H and 13 C-NMR spectra were registered using a Bruker Avance DPX-400 spectrophotometer (400 and 101 MHz) in DMSO-d6.…”

Section: Instrumentationmentioning

confidence: 99%

“…When different functional groups that interact with biological receptors are added to this ring, moiety compounds with extraordinary properties are obtained. Thiadiazoles and their derivatives have various biological and medicinal characteristics such as antimicrobial [1], anticancer [2], antibacterial, antiviral [3], antifungal [4] antitubercular [5], antihypertensive [6], anticonvulsant [7], diuretic [8], antioxidant [9] properties. They are also used for various applications such as pesticides, herbicides, and insecticides in the agriculture field [10].…”

Section: Introductionmentioning

confidence: 99%

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Novel Bis-1,3,4-Thiadiazoles Derivatives: Synthesis, Spectroscopic Characterization, DFT Calculations and Evaluation of their Antimicrobial and Antioxidant Activities

Çakmak

Çavuş

2023

Cumhuriyet Science Journal

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Two new, bis-1,3,4-thiadiazoles derivatives (I and II), were prepared by cyclization reaction of oxalic acid with N-alkyl/allyl thiosemicarbazides and phosphorous oxychloride (POCl3). Then the newly prepared products screened for their antimicrobial and antioxidant activities. The biological activity results shown that tested compounds exhibited effective antibacterial activity against six different bacteria. However, the compound II demonstrated greater ABTS˙+ scavenging ability. The characterization of the synthesized molecules was done by FT-IR, 1H NMR, 13C NMR spectroscopic methods and elemental analysis. Moreover, the experimental FT-IR and NMR spectra of the molecules were compared with the results calculated at the cc-pvtz, 6-311g(2d,2p), and 6-311++g(2d,2p) levels of theory. The effect of substituted groups on the spectral and electronic properties of the compounds was investigated. NCI and QTAIM analyses were performed to examine the effects of allyl group and intramolecular interactions on σ and π bonds. How the N-H bonds of the substituted groups affect the bond degrees was investigated using Fuzzy, Laplacian and Mayer approaches, and the relationship of the data with the antioxidant properties of the compounds was examined. In addition, the relationship between bond stretching force constant and intrinsic bond strength index, electron density, and delocalization index for some bonds was revealed.

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“…These observed are compatible with the literature[25][26][27]. The chemical shift values are presented in Table3 1. H NMR values of the compounds (δ, ppm, in nDMSO-d6).…”

supporting

confidence: 89%

Section: Instrumentationmentioning

confidence: 99%