Thiabendazole/bentonites hybrids as controlled release systems

Cavalcanti, Graycyellê R.S.; Fonseca, Maria G.; Filho, Edson Cavalcanti da Silva; Jaber, Maguy

doi:10.1016/j.colsurfb.2018.12.030

Cited by 43 publications

(14 citation statements)

References 39 publications

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“…The functionalization with surfactants improves the already valuable performances of clay minerals [8][9][10][11][12][13][14][15][16][17][18][19] in terms of affinity towards organic drug molecules and stability of the formulation [20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Modified Montmorillonite as Drug Delivery Agent for Enhancing Antibiotic Therapy

et al. 2021

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The appealing properties of surfactant-intercalated Montmorillonites (Organo-montmorillonite, OMt) were successfully investigated to propose an effective drug delivery system for metronidazole (MNE) antibiotic therapy. This represents a serious pharmaceutical concern due to the adverse drug reactions and the low targeting ability of MNE. The non-ionic surfactant Tween 20 was used to functionalize montmorillonite, thus accomplishing the two-fold objective of enhancing the stability of clay dispersion and better controlling drug uptake and release. The adsorption process was performed under different experimental conditions and investigated by constructing the adsorption isotherms through high-performance liquid chromatography (HPLC) measurements. Powder X-ray diffraction (XRD) measurements were performed to characterize the MNE/OMt compounds. The gathered results revealed that the uptake of the drug occurs preferentially in the clay interlayer, and it is governed by positive cooperative processes. The presence of surfactant drives the adsorption into clay interlayer and hampers the adsorption onto external lamella faces. The good performances of the prepared OMt in the controlled release of the MNE were proved by investigating the release profiles under physiological conditions, simulating oral drug administration. Cytotoxicity measurements demonstrated the biocompatibility of the complexes and evidenced that, under specific experimental conditions, nanodevices are more biocompatible than a free drug.

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Section: Introductionmentioning

confidence: 99%

Modified Montmorillonite as Drug Delivery Agent for Enhancing Antibiotic Therapy

et al. 2021

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“…Clay minerals are an important class of natural materials which are natural and low-cost widely available phyllosilicates [1][2][3]. Naturally occurring bentonite are usually superimposed between layers of hydrated ions by ultrathin crystalline aluminosilicates (arround 1.0 nm).…”

Section: Introductionmentioning

confidence: 99%

Application of thiabendazole/bentonites hybrids as efficient antibacterial agent against Escherichia coli and Staphylococcus aureus

Lin¹,

Wang²,

Yin³

et al. 2021

Mater. Res. Express

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Clay minerals are commonly used in agriculture, light industry, cosmetics, pharmaceuticals and other fields because it has adsorption and cation exchange properties. In this work, cetyltrimethylammonium bromide (CTAB) as a modifier and thiabendazole (TBZ) as intercalation agent to prepare composite, and their potential use as antibacterial agent was evaluated. Thiabendazole is a kind of antiparasitic drug which began to be used abroad in the early 60’s. But soon after, it was discovered that it had a strong anti-fungal effect on many molds that affect vegetables, fruits, nuts and other crops. At present, it has been widely used in prevention and control abroad. Unmodified bentonite, modified bentonite and intercalated bentonite were characterized by x ray diffraction (XRD), Fourier transform infrared (FTIR), Energy dispersive x-ray spectroscopy (EDS) and Scanning electronic microscopy (SEM), and the antimicrobial properties of the compounds was investigated by Minimum inhibitory concentrations (MIC), Minimum bactericidal concentration (MBC) and Kirby-Bauer disc agar diffusion method. Among the three compounds, the ratio of modified bentonite to thiabenazole was 5:1 showed the highest antibacterial activity against Escherichia coli and Staphylococcus aureus. In the final, there are some figures about the SEM of E. coli and S. aureus that can indicate antibacterial of the antibacterial agent.

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“…Different materials for controlled release are reported in the literature, which have in common the use of phyllosilicates, which is justified because these materials are abundant in nature, are low cost, non-toxic, and have the ability to adsorb ions and/or molecules in their interlamellar space [10,11]. In addition, there is the potential diversity of their use, which is due to the ease with which these materials are modified [12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release

Lima

Coêlho

Silva³

et al. 2019

Materials

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Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol–gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug. The systems were characterized by X-ray diffraction (XRD), Therma analysis TG/DTG, and Fourier-transform infrared spectroscopy (FTIR) that supported the DDS’s formation. The hybrid showed a better drug incorporation capacity compared to the precursors, with a loading of 55.74, 49.53, and 4.71 mg g−1 for Talc + Ch, Talc, and Ch, respectively. The release assays were performed on a Hanson Research SR-8 Plus dissolver using apparatus I (basket), set to guarantee the sink conditions. The in vitro release tests showed a prolongation of the release rates of this drug for at least 4 h. This result proposes that the systems implies the slow and gradual release of the active substance, favoring the maintenance of the plasma concentration within a therapeutic window.

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Thiabendazole/bentonites hybrids as controlled release systems

Cited by 43 publications

References 39 publications

Modified Montmorillonite as Drug Delivery Agent for Enhancing Antibiotic Therapy

Modified Montmorillonite as Drug Delivery Agent for Enhancing Antibiotic Therapy

Application of thiabendazole/bentonites hybrids as efficient antibacterial agent against Escherichia coli and Staphylococcus aureus

Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release

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