Theta–gamma coupling in the prelimbic area is associated with heroin addiction

Zhu, Zhanpeng; Zheng, Yi; Wang, Hui; Ting, Hua; Wen, Qingyun; Zhang, Changzheng

doi:10.1016/j.neulet.2019.02.020

Cited by 11 publications

(20 citation statements)

References 30 publications

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“…This stands in contrast to observed decreases in patterns of theta-gamma coupling in neglected children 4 . However, both abnormally reduced 63 and enhanced 64 disruptions of normal cortical cross-frequency coupling are associated with circuit dysfunction and pathology. Furthermore, it is important to note that the timing of assessment necessarily occurs after early-life trauma in children, whereas our results reflect immediate changes occurring during/immediately after the adversity.…”

Section: Discussionmentioning

confidence: 99%

Adverse caregiving in infancy blunts neural processing of the mother

et al. 2020

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The roots of psychopathology frequently take shape during infancy in the context of parentinfant interactions and adversity. Yet, neurobiological mechanisms linking these processes during infancy remain elusive. Here, using responses to attachment figures among infants who experienced adversity as a benchmark, we assessed rat pup cortical local field potentials (LFPs) and behaviors exposed to adversity in response to maternal rough and nurturing handling by examining its impact on pup separation-reunion with the mother. We show that during adversity, pup cortical LFP dynamic range decreased during nurturing maternal behaviors, but was minimally impacted by rough handling. During reunion, adversityexperiencing pups showed aberrant interactions with mother and blunted cortical LFP. Blocking pup stress hormone during either adversity or reunion restored typical behavior, LFP power, and cross-frequency coupling. This translational approach suggests adversity-rearing produces a stress-induced aberrant neurobehavioral processing of the mother, which can be used as an early biomarker of later-life pathology.

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Section: Discussionmentioning

confidence: 99%

Adverse caregiving in infancy blunts neural processing of the mother

et al. 2020

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“…The dysregulation of circuit function has been linked to several neuropsychiatric disorders, including opioid dependency (Fingelkurts et al, 2008). Chronic morphine exposure has been linked to enhanced gamma power in the nucleus accumbens (NAc) of rodents (Reakkamnuan et al, 2017), while in a rat model of heroin addiction, enhanced theta-gamma phase-amplitude coupling in the prelimbic region was reported (Zhu et al, 2019). Less is known regarding the effects of mitragynine on neurophysiological systems function, although suppression of cortical low frequency rhythms as measured by electrocorticogram has been described (Yusoff et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Acute mitragynine administration suppresses cortical oscillatory power and systems theta coherence in rats

et al. 2020

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Background: Mitragynine is the major alkaloid of Mitragyna speciosa (kratom) with potential as a therapeutic in pain management and in depression. There has been debate over the potential side effects of the drug including addiction risk and cognitive decline. Aims: To evaluate the effects of mitragynine on neurophysiological systems function in the prefrontal cortex (PFC), cingulate cortex (Cg), orbitofrontal cortex, nucleus accumbens (NAc), hippocampus (HIP), thalamus (THAL), basolateral amygdala (BLA) and ventral tegmental area of rats. Methods: Local field potential recordings were taken from animals at baseline and for 45 min following mitragynine administration (10 mg/kg, intraperitoneally). Drug-induced changes in spectral power and coherence between regions at specific frequencies were evaluated. Mitragynine-induced changes in c-fos expression were also analyzed. Results: Mitragynine increased delta power and reduced theta power in all three cortical regions that were accompanied by increased c-fos expression. A transient suppression of gamma power in PFC and Cg was also evident. There were no effects of mitragynine on spectral power in any of the other regions. Mitragynine induced a widespread reduction in theta coherence (7–9 Hz) that involved disruptions in cortical and NAc connectivity with the BLA, HIP and THAL. Conclusions: These findings show that mitragynine induces frequency-specific changes in cortical neural oscillatory activity that could potentially impact cognitive functioning. However, the absence of drug effects within regions of the mesolimbic pathway may suggest either a lack of addiction potential, or an underlying mechanism of addiction that is distinct from other opioid analgesic agents.

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“…Whether similar relationships between electrophysiological alterations in prelimbic neurons and behavioral outcomes exist should be investigated. Theta-band activity in the prelimbic region has also recently been linked to addiction [79], and future research should evaluate if alterations in theta activity are related to changes in spine density and other morphological changes during ethanol withdrawal. Alcohol exposure also causes changes in dendritic morphology dorsal striatum [80], and relationships to changes in ventral striatum and frontal cortex should be investigated.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ethanol Exposure and Withdrawal on Neuronal Morphology in the Agranular Insular and Prelimbic Cortices: Relationship with Withdrawal-Related Structural Plasticity in the Nucleus Accumbens

et al. 2019

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The present study investigated the effects of chronic intermittent ethanol exposure and withdrawal on dendritic morphology and spine density in the agranular insular and prelimbic cortices. Adult male Sprague–Dawley rats were passively exposed to vaporized ethanol (~37 mg/L; 12 h/day) or air (control) for ten consecutive days. Dendritic length, branching, and spine density were quantified in layer II/III pyramidal neurons 24 hours or seven days following the final ethanol exposure. Compared to unexposed control animals there were structural alterations on neurons in the prelimbic cortex, and to a lesser extent the agranular insular cortex. The most prominent ethanol-related differences were the transient increases in dendritic length and branching in prelimbic neurons at 24 h post-cessation, and increased mushroom-shaped spines at seven days post-cessation. The results obtained in the prelimbic cortex are the opposite of those previously reported in the nucleus accumbens core (Peterson, et al. 2015), suggesting that these regions undergo distinct functional adaptations following ethanol exposure and withdrawal.

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Theta–gamma coupling in the prelimbic area is associated with heroin addiction

Cited by 11 publications

References 30 publications

Adverse caregiving in infancy blunts neural processing of the mother

Adverse caregiving in infancy blunts neural processing of the mother

Acute mitragynine administration suppresses cortical oscillatory power and systems theta coherence in rats

Effects of Ethanol Exposure and Withdrawal on Neuronal Morphology in the Agranular Insular and Prelimbic Cortices: Relationship with Withdrawal-Related Structural Plasticity in the Nucleus Accumbens

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