2011
DOI: 10.1007/s12311-011-0282-1
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Theta-Burst Stimulation of the Cerebellum Interferes with Internal Representations of Sensory-Motor Information Related to Eye Movements in Humans

Abstract: Continuous theta-burst stimulation (cTBS) applied over the cerebellum exerts long-lasting effects by modulating long-term synaptic plasticity, which is thought to be the basis of learning and behavioral adaptation. To investigate the impact of cTBS over the cerebellum on short-term sensory-motor memory, we recorded in two groups of eight healthy subject each the visually guided saccades (VGSs), the memory-guided saccades (MGSs), and the multiple memory-guided saccades (MMGSs), before and after cTBS (cTBS group… Show more

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Cited by 18 publications
(12 citation statements)
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“…As far as the stimulation pattern is concerned, cTBS has been reported to affect long‐term synaptic plasticity in the cerebral cortex (Huang et al ., ) and potentially also in the cerebellum (Colnaghi et al ., ). Therefore, application of cTBS could have affected specific mechanisms of cerebellar plasticity.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…As far as the stimulation pattern is concerned, cTBS has been reported to affect long‐term synaptic plasticity in the cerebral cortex (Huang et al ., ) and potentially also in the cerebellum (Colnaghi et al ., ). Therefore, application of cTBS could have affected specific mechanisms of cerebellar plasticity.…”
Section: Discussionmentioning
confidence: 97%
“…Moreover, theta‐stimulation patterns induce forms of long‐term potentiation (LTP) and long‐term depression (LTD) both at the mossy fiber–granule cells synapse (D'Angelo et al ., , ) and at the parallel fiber–Purkinje cell synapse (Koekkoek et al ., ; De Zeeuw & Yeo, ). It is therefore expected that cTBS caused plastic changes in the cerebellar cortical circuit, as also suggested for saccadic eye movement adaptation (Colnaghi et al ., ), eventually causing a long‐lasting disregulation of EBCC mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…The cerebellum is involved in precise control of motor processes at a high spatiotemporal resolution by fine-tuning sensorimotor integration [810] and by providing feedforward control mechanisms that are paramount in the control of stance [11, 12]. Animal studies on cerebellar functions for body balance stressed that the cerebellar vermis plays a role in integrating visual [13], proprioceptive [14], and cutaneous input from the paw [1517].…”
Section: Introductionmentioning
confidence: 99%
“…Both the forward and recurrent models have been proposed as biologically plausible to explain cerebellar motor control functions and may indeed develop a complementary functionality. Experimental evidence locating forward models in the cerebellum has been provided using modeling, fMRI studies [82,54] and TMS [32,31].…”
Section: The Cerebellum 323mentioning
confidence: 99%