Theta burst magnetic stimulation over the pre-supplementary motor area improves motor inhibition

Obeso, Ignacio; Wilkinson, Leonora; Teo, James; Talelli, Penelope; Rothwell, John C.; Jahanshahi, Marjan

doi:10.1016/j.brs.2017.05.008

Cited by 36 publications

(35 citation statements)

References 64 publications

(103 reference statements)

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“…Theta band activity was generally lower in Go compared to Nogo trials, which is in line with previous findings Dippel et al, 2016Dippel et al, , 2017Huster et al, 2013;Liu et al, 2014;Müller et al, 2017;Vahid et al, 2018). Corroborating previous research underlining the importance of superior frontal regions for inhibitory control (Bari & Robbins, 2013;Dippel et al, 2016;Hung et al, 2018;Obeso et al, 2017;Xu et al, 2017), the beamforming analysis, contrasting Go and Nogo trials, revealed activation differences in the superior frontal gyrus encompassing the supplemental motor area.…”

Section: Resting Theta Activity Groupingsupporting

confidence: 89%

“…However, as mentioned above, evidence indicates that successful response inhibition performance is associated with elevated (event-related) theta band activity Dippel et al, 2016, 2017Huster et al, 2013Liu et al, 2014;Müller et al, 2017;Vahid et al, 2018). The reason is that superior prefrontal areas are well-known to be an important structure in a cortical network subserving inhibitory control (Bari & Robbins, 2013;Hung, Gaillard, Yarmak, & Arsalidou, 2018;Obeso et al, 2017;Xu et al, 2017), and that parietal regions become involved when conflicting sensory information modulated behavioral control (Adelhöfer et al, 2018;Bodmer & Beste, 2017;Fokin et al, 2008;Gothelf et al, 2007;Ocklenburg, Güntürkün, & Beste, 2011;Takeichi et al, 2010). Based on this, it is conceivable that there are stronger effects of conflicting information during inhibitory control in the low baseline and low modulation groups compared to the high baseline and high modulation groups at the behavioral and neurophysiological level.…”

mentioning

confidence: 99%

“…On a functional neuroanatomical level, these modulations (especially in the total theta power) may be associated with superior prefrontal and parietal structures. The reason is that superior prefrontal areas are well-known to be an important structure in a cortical network subserving inhibitory control (Bari & Robbins, 2013;Hung, Gaillard, Yarmak, & Arsalidou, 2018;Obeso et al, 2017;Xu et al, 2017), and that parietal regions become involved when conflicting sensory information modulated behavioral control (Adelhöfer et al, 2018;Bodmer & Beste, 2017;Fokin et al, 2008;Gothelf et al, 2007;Ocklenburg, Güntürkün, & Beste, 2011;Takeichi et al, 2010).…”

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confidence: 99%

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On the relevance of EEG resting theta activity for the neurophysiological dynamics underlying motor inhibitory control

Pscherer

Mückschel

Summerer

et al. 2019

Human Brain Mapping

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The modulation of theta frequency activity plays a major role in inhibitory control processes. However, the relevance of resting theta band activity and of the ability to spontaneously modulate this resting theta activity for neural mechanisms underlying inhibitory control is elusive. Various theoretical conceptions suggest to take these aspects into consideration. In the current study, we examine whether the strength of resting theta band activity or the ability to modulate the resting state theta activity affects response inhibition. We combined EEG‐time frequency decomposition and beamforming in a conflict‐modulated Go/Nogo task. A sample of N = 66 healthy subjects was investigated. We show that the strength of resting state theta activity modulates the effects of conflicts during motor inhibitory control. Especially when resting theta activity was low, conflicts strongly affected response inhibition performance and total theta band activity during Nogo trials. These effects were associated with theta‐related activity differences in the superior (BA7) and inferior parietal cortex (BA40). The results were very specific for total theta band activity since evoked theta activity and measures of intertrial phase coherency (phase‐locking factor) were not affected. The data suggest that the strength of resting state theta activity modulates processing of a theta‐related alarm or surprise signal during inhibitory control. The ability to voluntarily modulate theta band activity did not affect conflict‐modulated inhibitory control. These findings have important implications for approaches aiming to optimize human cognitive control.

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Section: Resting Theta Activity Groupingsupporting

confidence: 89%

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confidence: 99%

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confidence: 99%

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On the relevance of EEG resting theta activity for the neurophysiological dynamics underlying motor inhibitory control

Pscherer

Mückschel

Summerer

et al. 2019

Human Brain Mapping

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“…The rationale for selecting the r.IFG as the target region to examine the effects of TBS on IC among smokers is guided by the breadth of literature on the importance of the r.IFG in IC and our prior work with smokers that demonstrated disruption in r.IFG response during tasks probing inhibitory control (9,(15)(16)(17)(18). However, we acknowledge that TBS to the pre-SMA-a cortical node in the corticothalamic pathway-has been shown to impact inhibitory control task performance among healthy control participants (26,42,43) and therefore also warrants examination in future studies. It is important to note that acute administration of nicotine is known to improve executive function in both smokers and nonsmokers (44), including novelty detection which, in addition to inhibitory control, is also subserved by that r.IFG (45).…”

Section: Conclusion and Limitationsmentioning

confidence: 99%

Dissociable Effects of Theta-Burst Repeated Transcranial Magnetic Stimulation to the Inferior Frontal Gyrus on Inhibitory Control in Nicotine Addiction

et al. 2020

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Nicotine addiction, like other substance use disorders (SUD's), is associated with deficits in prefrontal mediated inhibitory control. The strength of inhibitory control task-based functional connectivity (tbFC) between the right inferior frontal gyrus (r.IFG) and thalamus (corticothalamic circuit) mediates the association between successful inhibition and smoking relapse vulnerability. However, the potential efficacy of theta burst stimulation (TBS) to the r.IFG, a treatment known to alter clinical symptoms among neuropsychiatric patients, has not been reported in a SUD population. This study utilized fMRI guided neuronavigation to examine the effects of TBS on inhibitory control among nicotine dependent individuals. Participants (N=12) were scanned while performing an inhibitory control task known to elicit inhibition-related activity in the r.IFG. Using a randomized, counterbalanced cross-over design, participants then received TBS over two visits: excitatory (iTBS) on one visit and inhibitory (cTBS) TBS on the other visit. The effects of each TBS condition on subsequent inhibitory control task performance were examined. A significant condition x time interaction was identified on trials requiring inhibitory control (F (1,10) = 7.27, p = .022, D = 1.63). iTBS improved inhibitory control, whereas cTBS impaired inhibitory control. Brain stimulation did not influence performance in control conditions including novelty detection and response execution. This is the first study to demonstrate that non-invasive neural stimulation using iTBS to the r.IFG enhances baseline inhibitory control among individuals with a SUD. Further research is needed to directly examine the potential parametric effects of TBS on corticothalamic tbFC in individuals with a SUD.

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“…The caudal SMA proper is anatomically connected with brain regions of the motor execution network, including the primary motor cortex (M1), spinal cord, basal ganglia, and cerebellum, and involved in motor execution (Muakkassa and Strick, 1979;Strick, 1991, 2005;Galea and Darian-Smith, 1994;He et al, 1995;Maier et al, 2002). The rostral preSMA mainly connects with the prefrontal cortex (PFC; Luppino et al, 1993;Lu et al, 1994;Wang et al, 2005) and involves higher-level processing, such as motor control and attention (Nakata et al, 2008;Boehler et al, 2010;Krüger et al, 2013;Cummine et al, 2017;Obeso et al, 2017). The resting-state functional connectivity (rsFC) patterns of the SMA subregions have been investigated in healthy subjects (Zhang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Differential Reorganization of SMA Subregions After Stroke: A Subregional Level Resting-State Functional Connectivity Study

Liu

Cai

et al. 2020

Front. Hum. Neurosci.

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Background and Purpose: The human supplementary motor area (SMA) contains two functional subregions of the SMA proper and preSMA; however, the reorganization patterns of the two SMA subregions after stroke remain uncertain. Meanwhile, a focal subcortical lesion may affect the overall functional reorganization of brain networks. We sought to identify the differential reorganization of the SMA subregions after subcortical stroke using the resting-state functional connectivity (rsFC) analysis. Methods: Resting-state functional MRI was conducted in 25 patients with chronic capsular stroke exhibiting well-recovered global motor function (Fugl-Meyer score >90). The SMA proper and preSMA were identified by the rsFC-based parcellation, and the rsFCs of each SMA subregion were compared between stroke patients and healthy controls. Results: Despite common rsFC with the fronto-insular cortex (FIC), the SMA proper and preSMA were mainly correlated with the sensorimotor areas and cognitiverelated regions, respectively. In stroke patients, the SMA proper and preSMA exhibited completely different functional reorganization patterns: the former showed increased rsFCs with the primary sensorimotor area and caudal cingulate motor area (CMA) of the motor execution network, whereas the latter showed increased rsFC with the rostral CMA of the motor control network. Both of the two SMA subregions showed decreased rsFC with the FIC in stroke patients; the preSMA additionally showed decreased rsFC with the prefrontal cortex (PFC). Conclusion: Although both SMA subregions exhibit functional disconnection with the cognitive-related areas, the SMA proper is implicated in the functional reorganization within the motor execution network, whereas the preSMA is involved in the functional reorganization within the motor control network in stroke patients.

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Theta burst magnetic stimulation over the pre-supplementary motor area improves motor inhibition

Abstract: Background: Stopping an ongoing motor response or resolving conflict induced by

Cited by 36 publications

References 64 publications

On the relevance of EEG resting theta activity for the neurophysiological dynamics underlying motor inhibitory control

On the relevance of EEG resting theta activity for the neurophysiological dynamics underlying motor inhibitory control

Dissociable Effects of Theta-Burst Repeated Transcranial Magnetic Stimulation to the Inferior Frontal Gyrus on Inhibitory Control in Nicotine Addiction

Differential Reorganization of SMA Subregions After Stroke: A Subregional Level Resting-State Functional Connectivity Study

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