Theta-associated high-frequency oscillations (110–160Hz) in the hippocampus and neocortex

Tort, Adriano Bretanha Lopes; Scheffer-Teixeira, Robson; Souza, Bryan C.; Draguhn, Andreas; Brankačk, Jurij

doi:10.1016/j.pneurobio.2012.09.002

Cited by 100 publications

(114 citation statements)

References 84 publications

(163 reference statements)

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“…PAC between theta and gamma oscillations has been described previously in different hippocampal regions of the rat [16,23,24]. This study shows for the first time a reduced PAC between theta and gamma oscillations during rapid-cycle Fig.…”

Section: Discussionsupporting

confidence: 83%

“…PAC = phase amplitude coupling VNS. Although, in theory, the normalized MI is insensitive to absolute changes in power of theta or gamma frequency bands, previous studies reported a correlation between theta power and strength of theta-gamma PAC [16,23]. This suggests that the amount of theta activity in the hippocampus determines to what degree gamma frequencies are modulated by this theta rhythm.…”

Section: Discussionmentioning

confidence: 92%

“…VNS was associated with a general reduction in broadband 2-100 Hz hippocampal power, which was most prominent in the theta frequency band (4-12 Hz) and gamma frequency ranges (>30 Hz), while little change was observed in an intermediate [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Hz band (Fig. 3a, b).…”

Section: The Effect Of Various Vns Parameters On Hippocampal Eegmentioning

confidence: 96%

“…Note that for plot (b), the direction of the y-axis has been reversed according to the methods of Tort et al [16]. The MI reflects the modulation of the amplitude of faster oscillations by the phase of slower oscillations, and has previously been used to characterize coupling of theta and gamma frequencies in the hippocampal region [16,23,24]. To calculate the MI, hippocampal EEG was band pass filtered to isolate the frequencies of interest (see below).…”

Section: Pac Analysismentioning

confidence: 99%

See 3 more Smart Citations

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle

et al. 2016

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Although vagus nerve stimulation (VNS) is widely used, therapeutic mechanisms and optimal stimulation parameters remain elusive. In the present study, we investigated the effect of VNS on hippocampal field activity and compared the efficiency of different VNS paradigms. Hippocampal electroencephalography (EEG) and perforant path dentate field-evoked potentials were acquired before and during VNS in freely moving rats, using 2 VNS duty cycles: a rapid cycle (7 s on, 18 s off) and standard cycle (30 s on, 300 s off) and various output currents. VNS modulated the evoked potentials, reduced total power of the hippocampal EEG, and slowed the theta rhythm. In the hippocampal EEG, theta (4-8 Hz) and high gamma (75-150 Hz) activity displayed strong phase amplitude coupling that was reduced by VNS. Rapid-cycle VNS had a greater effect than standard-cycle VNS on all outcome measures. Using rapid cycle VNS, a maximal effect on EEG parameters was found at 300 μA, beyond which effects saturated. The findings suggest that rapid-cycle VNS produces a more robust outcome than standard cycle VNS and support already existing preclinical evidence that relatively low output currents are sufficient to produce changes in brain physiology and thus likely also therapeutic efficacy.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 92%

Section: The Effect Of Various Vns Parameters On Hippocampal Eegmentioning

confidence: 96%

Section: Pac Analysismentioning

confidence: 99%

See 2 more Smart Citations

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle

et al. 2016

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“…It is important to note that the IMACC eventually fails when nonlinearity becomes too strong, i.e., as occurred to sawtooth waveforms with sharp edges [46,47]. This is expected because EMD cannot preserve spikes or shape edges in IMFs despite its tolerance to nonlinearity.…”

Section: Discussionmentioning

confidence: 99%

Spurious cross-frequency amplitude–amplitude coupling in nonstationary, nonlinear signals

Yeh

2016

Physica A: Statistical Mechanics and its Applications

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Recent studies of brain activities show that cross-frequency coupling (CFC) play an important role in memory and learning. Many measures have been proposed to investigate the CFC phenomenon, including the correlation between the amplitude envelopes of two brain waves at different frequencies — cross-frequency amplitude-amplitude coupling (AAC). In this short communication, we describe how nonstationary, nonlinear oscillatory signals may produce spurious cross-frequency AAC. Utilizing the empirical mode decomposition, we also propose a new method for assessment of AAC that can potentially reduce the effects of nonlinearity and nonstatonarity and, thus, help to avoid the detection of artificial AACs. We compare the performances of this new method and the traditional Fourier-based AAC method. We also discuss the strategies to identify potential spurious AACs.

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Multiple Oscillatory Push–Pull Antagonisms Constrain Seizure Propagation

Jiang

Cai

Worrell

et al. 2019

Annals of Neurology

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Theta-associated high-frequency oscillations (110–160Hz) in the hippocampus and neocortex

Cited by 100 publications

References 84 publications

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle

Vagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle

Spurious cross-frequency amplitude–amplitude coupling in nonstationary, nonlinear signals

Multiple Oscillatory Push–Pull Antagonisms Constrain Seizure Propagation

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