Thermotropic chirality enhancement of nanoparticles constructed from foldamer/bis(amino acid) complexes

Abstract

Thermo-responsive chiral nanomaterials have garnered much attention owing to their prospective applications in drug delivery, smart surface, chiroptical switches, etc. However, as the system temperature is increased, the nanostructures tend...

Visualization of Conformational Transitions of Artificial Polymeric Foldamers by AIEgen

“…Meanwhile, a relatively localized emission peak at 429 nm appears (Figures e,f and S9), implying that a few helical segments are transformed into the random coil ones. In particular, the helix content of Poly-1H can be estimated by means of peak-differentiation-imitating analysis of its fluorescence spectra . As shown in Figure S9, the fluorescence spectrum can be divided into two Gaussian peaks at 419 and 519 nm, which are assigned to the random coil conformation and the helical conformation, respectively.…”

“…In particular, the helix content of Poly-1H can be estimated by means of peak-differentiation-imitating analysis of its fluorescence spectra. 15 As shown in Figure S9, the fluorescence spectrum can be divided into two Gaussian peaks at 419 and 519 nm, which are assigned to the random coil conformation and the helical conformation, respectively. The peak area ratio is determined to be ∼7:93, indicating that the helix content of Poly-1H is 93% when the THF fraction is 10 vol %.…”

“…Over the decades, many artificial foldamers have been designed because they can mimic the folding behavior that occurs in biomacromolecules . In particular, unlike biomacromolecules, artificial foldamers can undergo the reversible conformational transitions in response to external stimuli including temperature, pH, light, solvents, , and additives − (Figure a). Therefore, artificial foldamers can serve as the ideal systems to simulate the structure–activity relationship of biomacromolecules …”

A cooperation tale of biomolecules and nanomaterials in nanoscale chiral sensing and separation

“…Since programmable DNA and peptide sequences enable the controllability of building blocks position at the nanometer level, biomolecules such as DNA, proteins, peptides, and amino acids (AAs) have emerged as desirable alternatives for controlling the chiral structure of NMs. [26][27][28][29][30][31] Moreover, polysaccharides possessing multiple chiral identification sites exhibit desirable enantiorecognition ability as well. 32,33 A harmonious relationship between biomolecules and nanotechnology has been created in chiral sensing.…”